Hepatoprotective Effects of Apricot against Acetaminophen-Induced Acute Hepatotoxicity in Rats

İsmet YILMAZ^1, , Aslı ÇETİN² and Yılmaz BİLGİdz

¹Department of Pharmacology, Faculty of Pharmacy, Inonu University, 44280 Malatya, Turkey

²Department of Histology-Embriology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey

³Department of Gastroenterology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey

Cite this paper:
İsmet YILMAZ, Aslı ÇETİN and Yılmaz BİLGİÇ. Hepatoprotective Effects of Apricot against Acetaminophen-Induced Acute Hepatotoxicity in Rats. American Journal of Pharmacological Sciences. 2015; 3(2):44-48. doi: 10.12691/ajps-3-2-3

Abstract

This study was to investigate the hepatoprotective effects of sun-dried organic apricot (SDOA) supplementation to chow against acetaminophen(APAP)-induced acute hepatotoxicity in rats. In this study, 24 female rats were randomized into four groups (n=6/groups). Blood and liver tissue samples were subjected to biochemical and histological examinations. SDOA consumption have strongly hepatoprotective effects againist APAP- induced acute hepatotoxicity in rats. The SDOA supplementation over a 45-day feeding period showed a beneficial effect against APAP-induced acute hepatotoxicity in rats, as reflects by histologycal and biochemical findings. Therefore, for humans in case of overdose APAP administration or chronic APAP treatments apricot consumption may be recommended.

Keywords:
acetaminophene hepatotoxicity apricot rat

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