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Parlakpınar H, Olmez E, Acet A, Ozturk F, Taşdemir S, Ateş B, Gul M, Otlu A.: Beneficial effects of apricot-feeding on myocardial ischemiareperfusion injury in rats. Food and Chemical Toxicology, 2009; 47: 802-08.

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Article

Hepatoprotective Effects of Apricot against Acetaminophen-Induced Acute Hepatotoxicity in Rats

1Department of Pharmacology, Faculty of Pharmacy, Inonu University, 44280 Malatya, Turkey

2Department of Histology-Embriology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey

3Department of Gastroenterology, Faculty of Medicine, Inonu University, 44280 Malatya, Turkey


American Journal of Pharmacological Sciences. 2015, Vol. 3 No. 2, 44-48
DOI: 10.12691/ajps-3-2-3
Copyright © 2015 Science and Education Publishing

Cite this paper:
İsmet YILMAZ, Aslı ÇETİN, Yılmaz BİLGİÇ. Hepatoprotective Effects of Apricot against Acetaminophen-Induced Acute Hepatotoxicity in Rats. American Journal of Pharmacological Sciences. 2015; 3(2):44-48. doi: 10.12691/ajps-3-2-3.

Correspondence to: İsmet  YILMAZ, Department of Pharmacology, Faculty of Pharmacy, Inonu University, 44280 Malatya, Turkey. Email: yilmaz.ismet@inonu.edu.tr

Abstract

This study was to investigate the hepatoprotective effects of sun-dried organic apricot (SDOA) supplementation to chow against acetaminophen(APAP)-induced acute hepatotoxicity in rats. In this study, 24 female rats were randomized into four groups (n=6/groups). Blood and liver tissue samples were subjected to biochemical and histological examinations. SDOA consumption have strongly hepatoprotective effects againist APAP- induced acute hepatotoxicity in rats. The SDOA supplementation over a 45-day feeding period showed a beneficial effect against APAP-induced acute hepatotoxicity in rats, as reflects by histologycal and biochemical findings. Therefore, for humans in case of overdose APAP administration or chronic APAP treatments apricot consumption may be recommended.

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