In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice

Faisal Asif¹, Tania Sultana¹, Md. Didaruzzaman Sohel^1, , Md. Helal Uddin Sumon², Md. Hassan Kawsar¹ and Md. Ashraful Islam¹

¹Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

²Department of Pharmacy, University of Development Alternative, Dhaka, Bangladesh

Cite this paper:
Faisal Asif, Tania Sultana, Md. Didaruzzaman Sohel, Md. Helal Uddin Sumon, Md. Hassan Kawsar and Md. Ashraful Islam. In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice. American Journal of Pharmacological Sciences. 2014; 2(2):32-36. doi: 10.12691/ajps-2-2-1

Abstract

This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.

Keywords:
dissolution study gastric medium mango juice metronidazole release

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