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Sugimoto K., Araki, N., Ohmori, M., Harada, K., Cui, Y., Tsuruoka S., Kawaguchi A., Fujimura A. Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam. Eur. J. Clin. Pharmacol. 62(3): 209-15. 2006.

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Article

In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice

1Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh

2Department of Pharmacy, University of Development Alternative, Dhaka, Bangladesh


American Journal of Pharmacological Sciences. 2014, Vol. 2 No. 2, 32-36
DOI: 10.12691/ajps-2-2-1
Copyright © 2014 Science and Education Publishing

Cite this paper:
Faisal Asif, Tania Sultana, Md. Didaruzzaman Sohel, Md. Helal Uddin Sumon, Md. Hassan Kawsar, Md. Ashraful Islam. In Vitro Dissolution Pattern of Metronidazole Film Coated Tablet in Presence of Fruit Juice. American Journal of Pharmacological Sciences. 2014; 2(2):32-36. doi: 10.12691/ajps-2-2-1.

Correspondence to: Md.  Didaruzzaman Sohel, Department of Pharmacy, State University of Bangladesh, Dhaka, Bangladesh. Email: sohelphr15@gmail.com

Abstract

This study concentrates on dissolution of drug in presence of fruit juice specifically mango juice. This work aspires current research to study the dissolution approach pattern of commercial formulation of metronidazole in Bangladesh commercially available eight brands of metronidazole film coated tablets were studied in gastric medium (pH 1.2). All brands got reasonably higher dissolution release mainly M02 (84.79%), M05 (75.86%), M06 (72.53%) and M07 (86.48%) were released relatively faster than other sample in 15 to 50 minutes. Therefore, Mango juice assists to enhance the therapeutic response of metronidazole on set of quick response.

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