Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol

Nwaehujor Chinaka O^1, , Asuzu Onyeka V² and Asuzu Isaac U³

¹Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria

²Department of Animal Production and Health, Faculty of Agriculture, Federal University, Oye, Oye-ekiti, Ekiti State, Nigeria

³Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

Cite this paper:
Nwaehujor Chinaka O, Asuzu Onyeka V and Asuzu Isaac U. Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol. American Journal of Pharmacological Sciences. 2014; 2(1):24-26. doi: 10.12691/ajps-2-1-5

Abstract

D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for membrane stabilizing potentials in red blood cells of alloxan-induced diabetic albino Swiss mice. Blood from diabetic animals treated with different doses of the compound (8, 4, 2 mg/kg) and Glibenclamide (2 mg/kg) were measured for membrane stability at different saline concentrations. The MCF values and their corresponding percentage stabilization were increased in the treatment groups compared to the negative control. The result suggests that D-3-O-methylchiroinositol possesses membrane stabilizing potentials.

Keywords:
D-3-O-methylchiroinositol Piliostigma thonningii osmotic fragility membrane stabilization red blood cells diabetes albino Swiss mice

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