American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: Editor-in-chief: Srinivas NAMMI
Open Access
Journal Browser
American Journal of Pharmacological Sciences. 2014, 2(1), 24-26
DOI: 10.12691/ajps-2-1-5
Open AccessArticle

Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol

Nwaehujor Chinaka O1, , Asuzu Onyeka V2 and Asuzu Isaac U3

1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria

2Department of Animal Production and Health, Faculty of Agriculture, Federal University, Oye, Oye-ekiti, Ekiti State, Nigeria

3Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria

Pub. Date: February 07, 2014

Cite this paper:
Nwaehujor Chinaka O, Asuzu Onyeka V and Asuzu Isaac U. Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol. American Journal of Pharmacological Sciences. 2014; 2(1):24-26. doi: 10.12691/ajps-2-1-5


D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for membrane stabilizing potentials in red blood cells of alloxan-induced diabetic albino Swiss mice. Blood from diabetic animals treated with different doses of the compound (8, 4, 2 mg/kg) and Glibenclamide (2 mg/kg) were measured for membrane stability at different saline concentrations. The MCF values and their corresponding percentage stabilization were increased in the treatment groups compared to the negative control. The result suggests that D-3-O-methylchiroinositol possesses membrane stabilizing potentials.

D-3-O-methylchiroinositol Piliostigma thonningii osmotic fragility membrane stabilization red blood cells diabetes albino Swiss mice

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


[1]  Elekwa I, Monanu MO and Anosike EO (2003) Effects of aqueous extracts of Garcinia kola seeds on membrane stability of HbAA, HbAS and HbSS human erythrocytes. Global J. of Medical Sciences 2 (2): 97-101.
[2]  Parpart AK, Lorenz PB, Parpart ER, Gregg JR and Chase AM (1947) The osmotic resistance (fragility) of human red cells. J. Clin. Invest, 26, 636-638.
[3]  Guest GM (1948) Osmometric behaviour of normal and abnormal human erythrocytes. Blood, 3; 541.
[4]  Asuzu IU and Nwaehujor CO (2013). The Anti-diabetic, hypolipidemic and anti-oxidant activities of D-3-O-methylchiroinositol in alloxan-induced diabetic rats. Hygeia: Journal of Drug and Medicine, 5 (2) 27-33.
[5]  Asuzu IU, Gray AI, Waterman PG (1999). The anti-helmintic activity of D-3-O-methylchiroinositol isolated from Piliostigma thonningii stem bark extract. Fitoterapia 70: 77.
[6]  Asuzu IU and Onu OU (1994). Antihelmintic activity of the ethanolic extract of Piliostigma thinningii bark in Ascaridia galli infected chickens. Fitoterapia. 65: 291-294.
[7]  Ibeh GI, Anosike E. and Ekeke GI. (1992) Effects of age on erythrocyte membrane ATPases in normal and sickle cells. Nig. J. Biochem. 7: 38-46.