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Elekwa I, Monanu MO and Anosike EO (2003) Effects of aqueous extracts of Garcinia kola seeds on membrane stability of HbAA, HbAS and HbSS human erythrocytes. Global J. of Medical Sciences 2 (2): 97-101.

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Article

Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol

1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria

2Department of Animal Production and Health, Faculty of Agriculture, Federal University, Oye, Oye-ekiti, Ekiti State, Nigeria

3Department of Veterinary Physiology and Pharmacology, University of Nigeria, Nsukka, Nigeria


American Journal of Pharmacological Sciences. 2014, Vol. 2 No. 1, 24-26
DOI: 10.12691/ajps-2-1-5
Copyright © 2014 Science and Education Publishing

Cite this paper:
Nwaehujor Chinaka O, Asuzu Onyeka V, Asuzu Isaac U. Membrane Stability of Red Blood Cells in Diabetic Mice Treated with D-3-O-Methylchiroinositol. American Journal of Pharmacological Sciences. 2014; 2(1):24-26. doi: 10.12691/ajps-2-1-5.

Correspondence to: Nwaehujor  Chinaka O, Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, P.M.B. Calabar, Nigeria. Email: chinaka_n@yahoo.com

Abstract

D-3-O-methylchiroinositol isolated from the stem bark of Piliostigma thonningii was evaluated for membrane stabilizing potentials in red blood cells of alloxan-induced diabetic albino Swiss mice. Blood from diabetic animals treated with different doses of the compound (8, 4, 2 mg/kg) and Glibenclamide (2 mg/kg) were measured for membrane stability at different saline concentrations. The MCF values and their corresponding percentage stabilization were increased in the treatment groups compared to the negative control. The result suggests that D-3-O-methylchiroinositol possesses membrane stabilizing potentials.

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