Oxidative Stress Markers in Pregnant Women with Preeclampsia

Leidiane de Lucca¹, Francisco Maximiliano Pancich Gallarreta² and Thissiane de Lima Gonçalves^1,

¹Postgraduate Program in Pharmaceutical Sciences, Department of Clinical and Toxicology Analysis, Center of Healthy Sciences, Federal University of Santa Maria (UFSM), Santa Maria (RS), Brazil

²Departamet of Obstetrics and Gynecology, Federal University of Santa Maria (UFSM), Santa Maria (RS), Brazil

Cite this paper:
Leidiane de Lucca, Francisco Maximiliano Pancich Gallarreta and Thissiane de Lima Gonçalves. Oxidative Stress Markers in Pregnant Women with Preeclampsia. American Journal of Medical and Biological Research. 2015; 3(3):68-73. doi: 10.12691/ajmbr-3-3-1

Abstract

Preeclampsia is a very important multisystem disorder to be specific to pregnancy, it is a disease mainly characterized by hypertension and proteinuria, but with unknown etiology that exposes the mother and the newborn to serious risks. One of the main factors involved in the pathophysiology of preeclampsia is oxidative stress and the rate of oxidative stress is measured by the ratio between the reactive oxygen species produced in the body called free radicals, and antioxidants produced by the body or absorbed through the diet. The excess of these free radicals have harmful effects, such as peroxidation of membrane lipids and aggression to tissue and membranes proteins as well as to membranes, enzymes, carbohydrates and DNA. Hypertensive disorders in pregnancy are a major cause of morbidity and maternal and fetal mortality. Preeclampsia is classified as a type of hypertensive complication that affects many pregnant women worldwide. The pregnancy and preeclampsia are conditions that increase susceptibility to oxidative stress, which in turn contributes to numerous complications, further aggravating the condition.

Keywords:
Oxidative Stress Pregnancy Preeclampsia Biomarkers

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