Galactogogue Effects of Two Annual Leafy Vegetables Euphorbia Hirta and Manihot Esculenta in Adult Female Wistar Rats

Adepo Yapo Prosper^1, , Soro soronikpoho¹, Kouassi Konan Armand Marcelin², Touzou Bléou Jean-Jaurès¹ and Koffi Kouadio Ernest¹

¹Biochemistry and Food Science Unit, Faculty of Biosciences, Félix Houphouet-Boigny University of Abidjan, Côte d’Ivoire, PO BOX 582 Abidjan 22

²Pharmacodynamics-Biochemistry Unit, Faculty of Biosciences, Félix Houphouet-Boigny University of Abidjan, Côte d’Ivoire, PO BOX 582 Abidjan 22

Cite this paper:
Adepo Yapo Prosper, Soro soronikpoho, Kouassi Konan Armand Marcelin, Touzou Bléou Jean-Jaurès and Koffi Kouadio Ernest. Galactogogue Effects of Two Annual Leafy Vegetables Euphorbia Hirta and Manihot Esculenta in Adult Female Wistar Rats. American Journal of Food Science and Technology. 2024; 12(5):183-186. doi: 10.12691/ajfst-12-5-7

Abstract

There are very few solutions available to combat galloping hypogalactia. The aim of this study was to evaluate the galactogogue effect of Euphorbia hirta and Manihot esculenta in adult female Wistar rats with a view to using them as lactogenic plants. The nutrient content of these leafy vegetables and the plasma concentration of prolactin in treated female rats were calculated using standard methods. The results recorded for Euphorbia hirta and Manihot esculenta were respectively: protein (14.41±0.02%; 26.12±0.18%), carbohydrate (35.43±5.30%; 14.37±1.3%), lipid (3.8±0.13%; 6.8±0.13%), dietary fibre (37.16±1.55%; 43.2±0.51%), ash (9.2 ± 0.13%; 6.2± 0.11%), polyphenols (368.66±50.75 mg EAG/ g DM; 375.5±4.78 mg EAG/ g DM), flavonoids (290.66±48.36 mg EQ/ g DM; 283 78± 3.9 mgEQ/ g DM). Furthermore, plasma prolactin concentrations were similar in female rats treated with dry aqueous extracts of Euphorbia hirta (15.22± 0.67 ng/mL), Manihot esculenta (12.52 ± 0.57 ng/mL) and galactogil (15.15 ± 0.07 ng/mL), however, the said plasma prolactin concentrations recorded were significantly different from those of control female rats treated with distilled water (5.18 ± 0.78) ng/mL. This suggests the presence of a lactogenic active ingredient in Euphorbia hirta and Manihot esculenta. These two leafy vegetables could help improve milk production in nursing mothers. However, further studies are needed to assess the lactogenic power of the leafy vegetables studied in combination.

Keywords:
Nutrients Euphorbia hirta Manihot esculenta prolactin

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]	Baudin B., 2014. Malnutrition et sous-alimentation. Revue Francophone des Laboratoires. 2014, pp. 25–37.
[2]	Gatti L., 2008. Maternal perceptions of insufficient milk supply in breastfeeding. J Nurs Scholarsh, 40: 355-363.
[3]	Thulier D., Mercer J. 2009. Variables associated with breastfeeding duration. J Obstet Gynecol Neonatal Nurs 38: 259-268.
[4]	Eidelman, A.I., Schanler R.J., 2012. Breastfeeding and the Use of Human Milk. Pediatrics, 129, e827.
[5]	Salanave B. D. L. C., Boudet B. J., Castetbon K., 2014 Durée de l’allaitement maternel en France (Épifane 2012-2013). Bull Epidémiol Hebd, 27 : 450-457.
[6]	UNICEF., 2013. L’allaitement maternel exclusif: une nécessité absolue. Rapport technique. 5p.
[7]	Adepo Y.P., Soro S., Touzou B.J.J., Chatigre K.O., Koffi E., Biego G.H.& Kati-Coulibaly S. 2022. Etude des pratiques de l’allaitement maternel chez les nourrissons de 0 à 6 mois, Journal of Food Research, 11(1): 23-27.
[8]	Victora C. G., Bahl R., Barros A. J., Franca G. V., Horton S. 2015. Breastfeeding in the 21st century: epidemiology, mechanisms, and lifelong effect, 387: 475-490.
[9]	Doukouré M., Bayala B., Guenné S., Tindano B., and Belemtougri R., 2018. Phytochemical Composition, Toxicity, Antioxidant and Lactogenic Activities of Euphorbia hirta (L.). International Journal of Advanced Research, 6 : 322-335.
[10]	Salifou A., Alidou C., Tchobo F.P & Soumanou M.M. 2015 Caractérisation physique et valorisation des amandes de trois espèces de courge (Citrulus lanatus, Lagenaria siceraria et Cucumeropsis edulus) produites au Bénin. Bulletin de la Recherche Agronomique du Bénin (BRAB) Numéro 78 BRAB en ligne (on line) sur le site web http://www.slire.net ISSN sur papier (on hard copy) : 1025-2355 et ISSN en ligne (on line) : 1840-7099, 38-43 P.
[11]	Sawadogo L., Houdebine, L.M., Thibault, J.F., Rouau X., Ollivier-Bousquet, M., 1988. Effect of peptic on prolactin and growth hormone secretion in the ewe and on the induction of casein synthesis in the rat. Reprod. Nutr. Develop., 28: 293-301.
[12]	Houdebine, L.M., Sawadogo, L. and Sepehri, H., 1990. Etude de l’action lactogène de la bière. Exp. Sci. Française, 147: 1-4.
[13]	A.O.A.C. 1975. Official Methods of Analysis, Association of Agricultural 12ème édition, CHEM. Washington (USA). pp.75-80.
[14]	A.O.A.C. 1990. Officinal methods of analysis. Association of Official Analytical Chemists.
[15]	FAO, 2002-Food energy methods of analysis and conversion factors, FAO Ed, Rome, Italie, 97 p.
[16]	Meda A, Lamien C. E, Romito M, Millogo J, Nacoulma O. G 2005: Determination of the total phenolic, flavonoid and proline contents in Burkina Fasan honey, as well as their radical scavenging activiity. Food Chem, 91, 571-577.
[17]	Singleton, G.R. and Brown, P.R. 1999. Management of mouse plagues in Australia: integration of population ecology, biocontrol and best farm practice. In: Cowan, D.P. and Feare, C.J., ed., Advances in vertebrate pest manage-ment. Zoological Library Vol. 7 (in press).
[18]	Djiane J. and Kelly P.A., 1984. Prolactine. "Médecine de la reproduction masculine" édité par Schaison, G., Bouchard P., Machoudeaux J. and Labrie F., Flammarion Médecine-Sciences - Presses de l’Université de Montréal, 141-146.
[19]	Atalar I, Dervisoglu M., 2015. Optimization of spray drying process parameters for kefir powder using response surface methodology. LWT-Food Science and Technology 60:751- 757.
[20]	Koko C. A. Diomandé M Kouamé B. K Yapo E. S. S Kouassi J. N 2016. Caractérisation physicochimique des graines de quartoze variétés de niébé (Vigna unguiculata L. Walp.) de Côte-d’Ivoire. International Journal of Innovation and Applied Studies Vol 17 NO 2 pp. 496-505. ISS 2028-9324.
[21]	Wang Y.C, Chauang Y.C, Hsu H.W. 2008. The flavonoid, carotenoid and pectin content in peels of citrus cultivated in Taaiwan. Food Chemistry. 106, 1, 277-284.
[22]	Kratchanova M., Pavlova E., Panchev I. 2004. The effect of microwave heating of fresch orange on the fruit tissue and quality of extracted pectin. Carbohydrates polymers 56 181 185.
[23]	Brou K. G, Mamyrbekova-Bekro J. A, Dogbo D., Odette G. S. J. Bekro Yves-Alain 2010. Sur la Composition Phytochimique Qualitative des Extraits bruts Hydrométhanoliques des Feuilles de 6 Cultivars de Manihot Esculenta Crantz de Côte d’Ivoire. European Journal of Scientific Research ISSN 1450-216X Vol.45 No.2, pp.200-211 Euro Journals Publishing, Inc. http:// www.eurojournals.com/ejsr.htm.
[24]	Acworth L. Balley B. 1995. The handbook of oxidative metabolism, Ed. FSA Inc, Chelmesford, 37 p.
[25]	Ferguson L (2001). Role of plant polyphenols in genomic stability.Mutation Research. for cardiovascular health. Canadian Journal of Cardiology, 26: 17-21.
[26]	Zhou H, Hong J., Shu P, Juan Ni, Qin M, (2009). A new dicoumarin and anticoagulant activity from Viola yedoensis Makino. Fitoterapia, 80 : 283-285.