Synthesis and Chemical Reactivity of some new Fluorine Substituted Pyrazolopyrimidine Derivatives and Their Effect on Cellobiase Activity Produced by Fungi

Reda Abdul-Rahman¹ and Dina Abed Bakhotmah, Montaha Fakhorji^1,

¹Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Cite this paper:
Reda Abdul-Rahman and Dina Abed Bakhotmah, Montaha Fakhorji. Synthesis and Chemical Reactivity of some new Fluorine Substituted Pyrazolopyrimidine Derivatives and Their Effect on Cellobiase Activity Produced by Fungi. World Journal of Organic Chemistry. 2017; 5(1):1-5. doi: 10.12691/wjoc-5-1-1

Abstract

Various fluorine substituted fused heteropolycyclic nitrogen systems containing a pyrazolopyrimidine moieties have been synthesized from the interaction between 6-mercaptopyrazolo[3,4-d]pyrimidines with bifunctional nitrogen and halogen compounds. The effect of these fluorinated systems on the activity of the cellobiase produced by Aspergillus Nidulans was evaluated. The outcome of the study discloses that, some of the compounds have shown promising activity in low concentration.

Keywords:
fused heteropolycyclic Aspergillus Nidulans pyrazolopyrimidine cellobiase fungi 6-mercaptopyrazolo fluoro heteropolycyclic

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