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Bakhotmah, D.A., Synthesis of Novel α-Amino Acids Bearing 1,2,4-Triazinone and Steroidal Moieties as Enzymatic Affects (Cellobaiase Activity) – Part II, Current Organic Synthesis, 13, 142-147, 2016.

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Synthesis and Chemical Reactivity of some new Fluorine Substituted Pyrazolopyrimidine Derivatives and Their Effect on Cellobiase Activity Produced by Fungi

1Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia


World Journal of Organic Chemistry. 2017, Vol. 5 No. 1, 1-5
DOI: 10.12691/wjoc-5-1-1
Copyright © 2017 Science and Education Publishing

Cite this paper:
Reda Abdul-Rahman, Dina Abed Bakhotmah, Montaha Fakhorji. Synthesis and Chemical Reactivity of some new Fluorine Substituted Pyrazolopyrimidine Derivatives and Their Effect on Cellobiase Activity Produced by Fungi. World Journal of Organic Chemistry. 2017; 5(1):1-5. doi: 10.12691/wjoc-5-1-1.

Correspondence to: Dina  Abed Bakhotmah, Montaha Fakhorji, Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia. Email: mfahkurji@stu.kau.edu.sa

Abstract

Various fluorine substituted fused heteropolycyclic nitrogen systems containing a pyrazolopyrimidine moieties have been synthesized from the interaction between 6-mercaptopyrazolo[3,4-d]pyrimidines with bifunctional nitrogen and halogen compounds. The effect of these fluorinated systems on the activity of the cellobiase produced by Aspergillus Nidulans was evaluated. The outcome of the study discloses that, some of the compounds have shown promising activity in low concentration.

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