Hui-Chun Chang¹, Bo-Han Wu², Yen-Ju Lin³, Yung-Hao Lin³, Yung-Hsiang Lin¹, Chen-Meng Kuan^1,

This preliminary clinical study reveals the possibilities of a weight loss kit with a prebiotic formula for weight management and metabolic improvement in volunteers. Considering the convenience, passive diets are a popular choice for some people for weight management. However, the synergic effect between passive diet kits and prebiotics has seldom been reported. 90 volunteers were enrolled in this two-month study and assigned them to normal diet (ND), weight loss program kit (WLPK), or WLPK with the prebiotic formula (WLPK-AKK) group based on purposive sampling. Anthropometric measurements, biochemical analysis, and fecal microbiome analysis were conducted at the baseline and 1 and 2 months. The prebiotic formula could reduce weight mass, fat mass, visceral fat, body fat percentage, triglyceride, total cholesterol, and LDL cholesterol of the subjects by 0.5 kg, 0.7 kg, 9 cm2, 0.6%, 2%, 1.6%, 1.2%, respectively. Also, it improved the abundance of A. muciniphila by 250% in comparison with the control group. In short, this study demonstrates that the weight loss kit with the prebiotic formula enables to facilitate the abundance of probiotics in the human intestines and comprehensively improve body weight and metabolic disorders.

prebiotic, obesity, overweight, weight loss, metabolic improvement