Journals A-Z
All Subjects
Free Journals
sciepub.com
Nanoscience and Nanotechnology Research
ISSN (Print): 2372-4668 ISSN (Online): 2372-4676 Website: https://www.sciepub.com/journal/nnr Editor-in-chief: Mehrdad Hamidi, Javad Verdi
Open Access
Journal Browser
Go
Issue 2, Volume 4
Article Metrics
  • 16705
    Views
  • 13684
    Saves
  • 0
    Citations
  • 1
    Likes
Export Article
Nanoscience and Nanotechnology Research. 2017, 4(2), 67-72
DOI: 10.12691/nnr-4-2-5
Open AccessReview Article

Solid Lipid Nanoparticles: A Review

Vishal J. Lingayat1, , Nilesh S. Zarekar1 and Rajan S. Shendge1

1Department of Pharmaceutics (PG), Sanjivani College of Pharmaceutical Education and Research, Kopargaon

Pub. Date: April 27, 2017
View Full Text Full Text PDF (160 KB) Full Text ePUB(466 KB)

Cite this paper:
Vishal J. Lingayat, Nilesh S. Zarekar and Rajan S. Shendge. Solid Lipid Nanoparticles: A Review. Nanoscience and Nanotechnology Research. 2017; 4(2):67-72. doi: 10.12691/nnr-4-2-5

Abstract

Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, clinical medicine, and research, as well as in other varied sciences. This review presents a broad treatment of solid lipid nanoparticles discussing their aims, production procedures, advantages, limitations and their possible remedies. This review presents a broad treatment of solid lipid nanoparticles discussing preparation method, characterization, route of administration of SLNs, generally carried out. Aspects of SLN route of administration and the invivo fate of the carriers are also discussed.

Keywords:
solid lipid nanoparticles methods of preparation evaluation route of administration

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Kamble, V., Jagdale, D. and Kadam, V., “Solid Lipid Nanoparticles as Drug Delivery System”, International Journal of Pharma and Bio Sciences, 1(3). 1-9. 2010.
 
[2]  Sarangi, M. and Padhi, S, “Solid Lipid Nanoparticles A Review”, Journal of Critical Reviews, 3 (3). 5-12. 2016.
 
[3]  Hanumanaik, M., Patel, S. and Ramya Sree, K., “Solid Lipid Nanoparticles A Review”, IJPSR, 4 (3). 928-940. 2013.
 
[4]  Garud, A., Singh, D. and Garud, N, “Solid Lipid Nanoparticles Method, Characterization and Applications”, International Current Pharmaceutical Journal, 1 (11). 384-393. 2012.
 
[5]  Kakadia, P. and Conway, B, “Solid Lipid Nanoparticles: A Potential Approach For Dermal Drug Delivery”, American Journal Of Pharmacological Sciences. 2 (5). 1-7. 2014.
 
[6]  Kamboj, S., Bala, S. and Nair, A., “Solid Lipid Nanoparticles An Effective Lipid Based Technology For Poorly Water Soluble Drugs”, International Journal Of Pharmaceutical Sciences Review And Research, 5 (2). 78-90. 2010.
 
[7]  Swathi, G., Prasanthi, N., Manikiran, S. and Ramara, N, “Solid Lipid Nanoparticles: Colloidal Carrier Systems For Drug Delivery”, Ijpsr, 1 (12).01-16.2010.
 
[8]  Yadav, P., Soni, G., Mahor, A., Alok, S., Singh, P. and Verma, A. “Solid Lipid Nanoparticles: An Effective and Promising Drug Delivery System- A Review”, Ijpsr, 5 (4). 1152-1162. 2014.
 
[9]  Wolfgang, M. and Karsten, M, “Adv. Drug. Deliv. Rev”, 47. 165-196. 2001.
 
[10]  Houli, L., Xiaobin, Z., Yukun, M. and Guangxi Z, “Solid Lipid Nanoparticles as Drug Delivery System”, J. Cont. Release, 133.238-244.2009.
 
[11]  Melike, U. Gulgun, Y, Int. J. Nanomedicine, 2(3). 289-300. 2007.
 
[12]  Rupenagunta, A., Somasundaram, I., Ravichandiram, V., Kausalya, J. and Senthilnathan, B, “Solid Lipid Nanopar-Ticles- A Versatile Carrier System”, J Pharm Res, 4. 2069-2075. 2011.
 
[13]  Reddy, R. and Shariff, A., “Solid Lipid Nanoparticles An Advanced Drug Delivery System”, Ijpsr, 4(1). 161-171. 2013.
 
[14]  Ramteke, K., Joshi, S. and Dhole, S., “Solid Lipid Nanoparticle: A Review”, IOSR Journal Of Pharmacy, 2(6). 34-44. 2012.
 
[15]  Munireddy, M., Thakur, R., Patel, R. and Mamatha, M, “Solid Lipid Nanoparticles an Effective Drug Delivery System”, American Journal of Pharm Tech Research, 2(3). 2012.
 
[16]  Khan, S “Solid Lipid Nanoparticles A Review”, World Journal Of Pharmacy And Pharmaceutical Sciences, 96-115. 2012.
 
[17]  Ekambaram, P., Sathali, A. and Priyanka, K, “Solid Lipid Nanoparticles and Lipid Nanostructures Overview”, Scientific Review &Chemical Communication, 2. 216-220. 2011.
 
[18]  Rawat, A., Jain, M. and Singh, A, “Studies on Binary Lipid Matrix Based Solid Lipidnanoparticles of Repaglinide”, In Vitro And In Vivo Evaluation, Journal Of Pharmaceutical Sciences. 2. 66-78. 2011.
 
[19]  Sinharanjan, V., Srivastava, S, Honey, G. and Jindal, V, “Solid Lipid Nanoparticles Trends and Implications In Drug Targeting”, International Journal of Advances In Pharmaceutical Sciences, 2. 212-238. 2010.
 
[20]  Muller, R., Schwarz, C., Mehnertw, and Lucks, J, “Production Of Solid Lipid Nanoparticles For Controlled Drug Delivery”, Int. Symp Control Release Bioact. Mater, 1., 480-481. 1993.
 
[21]  Yadav, N., Khatak, S. And Singh, S., “Solid Lipid Nanoparticles A Review”, International Journal of Applied Pharmaceutics, 5(2). 8-18. 2013.
 
[22]  Antonio, J. and Eliana, S, Adv. Drug Delivery Rev, 59, 478-490. 2007.
 
[23]  Vyas, S, and Khar, R, “Controlled Drug Delivery - Concepts and Advances”, First Edition, Vallabh Prakashan 38-50. 2002.
 
[24]  Joseph, R. and Vincent, H, “Controlled Drug Delivery - Fundamentals and Applications”, 2nd Edition, 4-33.
 
[25]  Omray, L., “Formulation and Characterization of Solid Lipid Nanoparticles for Transdermal Delivery of Testosterone” International Journal Of Pharma Sciences And Research (Ijpsr), 5. 323-328. 2014.
 
[26]  Chaturvedi, S. and Kumar, V, “Production Techniques of Lipid Nanoparticles: A Review”, Research Journal of Pharmaceutical, Biological And Chemical Sciences, 3. 525-537. 2012.
 
[27]  Schubert, M. and Muller-Goymann, C, “Solvent Injection as A New Approach For Manufacturing Lipid Nanoparticles--Evaluation Of The Method and Process Parameters”, Eur J Pharm Biopharm, 55. 125-131. 2003.
 
[28]  Pragati, S., Kuldeep, S, and Satheesh, M, “Solid Lipid Nanoparticles A Promising Drug Delivery Technology” International Journal of Pharmaceutical Sciences and Nanotechnology, 2(2). 509-516. 2009.
 
[29]  Meyer, E. and Heinzelmann, H. “Scanning Force Microscopy. Scanning Tunneling Microscopy II, Surface Science”, New York, Springer Verlag, 99-149.1992.
 
[30]  Drake, B., Prater, C., Weisenhorn, A., Gould S, Albrecht, T. and Quate, C, “Imaging Crystals Polymers And Process In Water With The AFM”. Sci, 243. 1586-9. 1989.
 
[31]  Chen, H., Chang, X., Du, D., Liu, W., Liu, J., Weng, T. and Yang,Y, et al. “Podophyllotoxin-Loaded Solid Lipid Nanoparticles for Epidermal Targeting”, J. Control. Rel. 110. 296-306. 2006.
 
[32]  Heiati, H., Tawashi, R. and Phillips, N, “Solid Lipid Nanoparticles As Drug Carriers - II. Plasma Stability And Bio-Distribution of Solid Lipid Noparticles Containing The Lipophilic Prodrug 3'azido-3'-Deoxythymidine Palmitate in Mice”, Int. J. Pharm,149. 255-265. 1997.
 
[33]  Cavalli, R., Caputo, O., Marengo, E., Pattarino, F. and Gasco M, “The Effects of Components of Micro Emulsions on Both Size and Crystalline Structure of Solid Lipid Nanoparticles (SLN) Containing A Series of Model Molecules”, Pharmazie, 53. 392-396. 1998.
 
[34]  Mühlen, A. and Mehnert, W. “Drug Release And Release Mechanism Of Prednisolone Loaded Solid Lipid Nanoparticles”, Pharmazie, 53. 552. 1998.
 
[35]  Eldem, T., Speiser, P. and Hincal, A, “Optimization Of Spray-Dried And Congealed Lipid Microparticles And Characterization Of Their Surface Morphology By Scanning Electron Microscopy, Pharm Res, 8. 47-54. 1991.
 
[36]  Speiser, P, “Lipidnanopellets als Tragersystem Fur Arzneimittel Zur Peroralem Anwendung”,European Patent No. EP 0167825. 1990.
 
[37]  Cavalli, R., Gasco, M., Chetoni, P., Burgalassi, S. and Saettone, M, “Solid Lipid Nanoparticles as Ocular Delivery System for Tobramycin”, Int. J. Pharm, 15. 241-5. 2002.
 
[38]  Greenberg, H., Shwayder, T., Bieszk, N. and Fivenson, D, “Clotrimazole Betamethasone Dipropionate: A Review Of Costs And Complications In The Treatment Of Common Cutaneous Fungal Infections”, Pediatric Dermatology, 19. 78-81. 2002.
 
[39]  Souto, E. and Müller, R, “The Use of SLN and NLC As Topical Particulate Carriers For Imidazole Antifungal Agents”, Pharmazie, 61. 431-437. 2006.
 
[40]  Ekambaram, P., Sathali, A. and Priyanka, K, “Solid Lipid Nanoparticles A Review”, Sci. Revs. Chem. Commun, 2(1), 80-102. 2012.
 
[41]  Machlin, L, “Vitamin E A Comprehensive Treatise” New York And Basel: Marcel Dekker 1980.
 
[42]  Garud, A., Singh, D. and Garud, N, “Solid Lipid Nanoparticles Method, Characterization and Applications”, International Current Pharmaceutical Journal, 1. 384-393. 2012.
 
[43]  Schubert, M. and Goymann, C “Solvent Injection as A New Approach for Manufacturing Lipid Nanoparticles– Evaluation of The Method and Process Parameters”, Eur J Pharm Biopharm, 55(1). 125-131. 2003.
 
[44]  Makai, M., Sanyi, E., Ekany, I. and Nemeth, I. “Structural Properties of Non-Ionic Surfactant, Glycerol, Paraffin Lyotropic Crystals”, Colloid Polym Sci, 281. 839-844. 2003.
 
[45]  Goymann, C., Swarbrick, J. and Boylan, J, “Liquid Crystals in Drug Delivery. In Eds. Encyclopedia of Pharmaceutical Technology”, New York and Basel: Marcel Dekker, 834-853. 2002.
 
[46]  Verma, V, And Ram, A, “Preparation Characterization and In-Vitro Release of Piroxicam-Loaded Solid Lipid Nanoparticles”, International Journal of Pharmaceutical Sciences and Nanotechnology, 3(3). 1136-1146. 2010.
 
[47]  Kaur, I., Bhandari, R., Bhandari ,S. and Kakkar, V, “Potential of Solid Lipid Nanoparticles In Brain Targeting” J Control Release, 127. 97-109. 2008.
 
[48]  Kumar, R. and Katare, O, “Lecithin Organogels as A Potential Phospholipid Structured System For Topical Drug Delivery: A Review”, AAPS. Pharmscitech, 6E298-E310. 2005.
 
[49]  YChien, Y., Keshary, P., Hung, Y, and Sarpotdar, P, “Comparative Controlled Skin Permeation of Nitroglycerin From Marketed Transdermal Delivery Systems”, J Pharm Sci, 72. 968-970. 1983.
 
[50]  Loxley, A, “Solid Lipid Nanoparticles for The Delivery of Pharmaceutical Actives”, Drug Delivery Technology, 9 (8). 2009.
 
[51]  Muèller, R., Maèder, K. And Sven Gohla, “Solid Lipid Nanoparticles for Controlled Drug Delivery A Review 0f The State of The Art”, European Journal 0f Pharmaceutics And Biopharmaceutics, 50. 161-177. 2000.
 
[52]  Pinto, J. and Muèller, R, “Pellets As Carriers 0f Solid Lipid Nanoparticles for Oral Administration 0f Drugs”, Die Pharmazie, 506-509. 1999.
 
[53]  MuèLler, R., Luèck, J., and Fuè, R, “GewebsspeziSche Arzneistoffapplikation”, German Patent Application No.197 45 950. 1. 1997.
 
[54]  Bhaskar, K., Anbu, J. Ravichandiran, V. and Venkateswarlu, Y, “Lipid Nanoparticles For Transdermal Delivery of Flurbiprofen Formulation, In Vitro, Ex Vivo and In Vivo Studies”, Lipids In Health and Disease, 8(6). 2009.
 
[55]  Ekambaram, P., Sathali, A. and Priyanka, K, “Solid Lipid Nanoparticles: A Review”, Scientific Reviews and Chemical. Communication, 2(1). 80-102. 2012.
 
[56]  Sznitowska, M., Gajewska, M. and Janicki, S., Eur J Pharmbiopharm, 52. 159-63. 2001.
 
[57]  Sznitowska, M., Janicki, S. and Gajewska, M, Acta Polonpharm, 57.61-4.2000.
 
[58]  Sanap, G. And Mohanta, G, “A Review Solid Lipid Nanoparticle A Potential Drug Delivery Carrier”, International Journal of Chemical and Pharmaceutical Analysis, (2). 52-62.2014.
 
Manuscript template