Dietary Borage Oil Promotes Gamma-linoleic Acid Accumulation in Dextran Sulfate Sodium-treated Mice but Does not Manipulate the Severity of Colitis

Ryoya Fujioka¹, Kazuo Nishiyama¹ and Masao Yamasaki^1,

¹Faculty of Agriculture, University of Miyazaki, 1-1 Gakuenkibanadai-nishi Miyazaki 889-2192, Japan

Cite this paper:
Ryoya Fujioka, Kazuo Nishiyama and Masao Yamasaki. Dietary Borage Oil Promotes Gamma-linoleic Acid Accumulation in Dextran Sulfate Sodium-treated Mice but Does not Manipulate the Severity of Colitis. Journal of Food and Nutrition Research. 2017; 5(3):151-155. doi: 10.12691/jfnr-5-3-2

Abstract

In this study, we examined the effect of borage oil (BO), which is rich in gamma-linolenic acid (GLA), on GLA accumulation in the bowel, and on the condition of dextran sulfate sodium (DSS)-induced colitis in mice. The results imply that dietary BO increased GLA accumulation in the liver and intestinal triglycerides (TG) and liver phospholipids (PL), whereas GLA accumulation in the intestinal PL was not significantly different between mice fed with BO and those with safflower oil diet. Although there were concerns about accumulation of arachidonic acid (AA) because it can be a substrate for the biosynthesis of proinflammatory eicosanoids, apparent AA accumulation in intestinal PL and exacerbation of colitis condition were not observed in BO groups. Taken together, it is considered that because of inefficient GLA accumulation in intestinal membrane, dietary BO did not manipulate DSS-induced colitis condition.

Keywords:
borage oil colitis dextran sulfate sodium gamma linolenic acid fatty acid composition

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