The Effect of a Nutritional Supplement on Chronic Kidney Disease Patients

Pei-Yu Wu¹, Chien-Tien Su², Hui-Wen Chang³, Alice Lan⁴ and Shwu-Huey Yang^1,

¹School of Nutrition and Health Sciences, Taipei Medical University, Taipei City 110, Taiwan

²Family Medicine, Taipei Medical University Hospital, Taipei City 110, Taiwan

³Department of Laboratory Medicine, Taipei Medical University Hospital, Taipei City 110, Taiwan

⁴New Bellus Enterprises Co., Ltd., Tainan City 72042, Taiwan

Cite this paper:
Pei-Yu Wu, Chien-Tien Su, Hui-Wen Chang, Alice Lan and Shwu-Huey Yang. The Effect of a Nutritional Supplement on Chronic Kidney Disease Patients. Journal of Food and Nutrition Research. 2016; 4(2):115-120. doi: 10.12691/jfnr-4-2-8

Abstract

The objective of this study was to evaluate the effects of UNECE U-LP200 on nutritional status and physical function in chronic kidney disease (CKD) patients. From November, 2010 to March, 2011, 33 participants (17 males and 16 females) with mean age 80.7±10.0 years old were recruited from three nursing homes in New Taipei City, Taiwan. All participants were diagnosed with CKD with blood urea nitrogen (BUN) levels ≧ 20 mg/dL or creatinine (Cr) levels ≧1.2mg/dL. The study was divided into three periods: the observation (month 0), intervention (month 1), and follow-up (month 2). During the intervention period, UNECE U-LP 200 was given to participants as a substitute for a snack. Anthropometric measurements, nutritional status, and biochemical measurements were obtained. Body weight and body mass index (BMI), as well as a nutritional indicator, geriatric nutritional risk index (GNRI), all increased after one month of the UNECE U-LP200 intervention (p < 0.05). Most of the biochemical measurements were within the normal range, with no significant differenced during the experiment, but plasma fasting blood glucose and triglyceride both improved after one month of the UNECE U-LP200 intervention (p < 0.05). The results thus show that UNECE U-LP200 was well-tolerated and could help the participants to maintain a good nutritional status and prevent physical damage.

Keywords:
chronic kidney failure chronic kidney disease nutritional supplement nutritional status renal

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References:

[1]	Wen, C.P., Cheng, T.Y.D., Tsai, M. K., Chang, Y.C., Chan, H.T., Tsai, S.P., Wen, S.F. et al. “All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan,” Lancet, 371 (9631). 2173-82. June 2008.
[2]	Hwang, S.J., Tsai, J.C., Chen, H.C, “Epidemiology, impact and preventive care of chronic kidney disease in Taiwan,” Nephrology, 15 (Suppl 2). 3-9. June 2010.
[3]	Kopple, J.D. “National Kidney Foundation K/DOQI clinical practice guidelines for nutrition in chronic renal failure,” American journal of kidney diseases, 37(1 Suppl 2). S66-S70. Jan 2001.
[4]	Kovesdy, C.P., Kopple, J.D., Kalantar-Zadeh, K. “Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy,” American journal of clinical nutrition, 97(6). 1163-77. June 2013.
[5]	Stratton, R.J., Bircher, G., Fouque, D., Stenvinkel, P., de Mutsert, R., Engfer, M., Elia, M.. “Multinutrient oral supplements and tube feeding in maintenance dialysis: a systematic review and meta-Analysis,” American journal of kidney diseases, 46 (3). 387-405. Sep 2005.
[6]	Caglar, K., Fedje, L., Dimmitt, R., Hakim, R.M., Shyr, Y., Ikizler, T.A. “Therapeutic effects of oral nutritional supplementation during hemodialysis,” Kidney International, 62 (3). 1054-9. Sep 2002.
[7]	Fouque, D., McKenzie, J., de Mutsert, R., Azar, R., Teta, D., Plauth M., Cano N, Renilon Multicentre Trial Study Group. “Use of a renal-specific oral supplement by haemodialysis patients with low protein intake does not increase the need for phosphate binders and may prevent a decline in nutritional status and quality of life,” Nephrology Dialysis Transplant, 23(9). 2902-10. Sep 2008.
[8]	Sharma, M., Rao, M., Jacob, S., Jacob, C.K. “A controlled trial of intermittent enteral nutrient supplementation in maintenance hemodialysis patients,” Journal of Renal Nutrition, 12(4). 229-37. Oct 2002.
[9]	Moretti, H.D., Johnson, A.M., Keeling-Hathaway, T.J. “Effects of protein supplementation in chronic hemodialysis and peritoneal dialysis patients,” Journal of Renal Nutrition, 19(4). 298-303. Jul 2009.
[10]	Beutler, K.T., Park, G.K., Wilkowski, M.J. “Effect of oral supplementation on nutrition indicators in hemodialysis patients,” Journal of Renal Nutrition, 7(2). 77-82. Apr 1997.
[11]	Kalantar-Zadeh, K., Braglia, A., Chow, J., Kwon, O., Kuwae, N., Colman, S., Cockram D.B., Kopple J.D. “An anti-inflammatory and antioxidant nutritional supplement for hypoalbuminemic hemodialysis patients: a pilot/feasibility study,” Journal of Renal Nutrition, 15(3). 318-31. Jul 2005.
[12]	Scott, M.K., Shah, N.A., Vilay, A.M., Thomas III, J., Kraus, M.A., Mueller, B.A. “Effects of peridialytic oral supplements on nutritional status and quality of life in chronic hemodialysis patients,” Journal of Renal Nutrition, 19(2). 145-52. Mar 2009.
[13]	Vaziri, N.D., Wong, J., Pahl, M., Piceno, Y.M., Yuan, J., DeSantis, T.Z., Ni Z., Nguyen T.H., Andersen G.L. “Chronic kidney disease alters intestinal microbial flora,” Kidney International, 83(2) 308-15. Feb 2013.
[14]	Bouillanne, O., Morineau, G., Dupont, C., Coulombel, I., Vincent, JP, Nicolis, I., Benazeth S., Cynober L., Aussel C. “Geriatric Nutritional Risk Index: a new index for evaluating at-risk elderly medical patients,” American journal of clinical nutrition, 82 (4). 777-83. Oct 2005.
[15]	Detsky, A.S., McLaughlin J.R., Baker, J.P., Johnston, N., Whittaker, S., Mendelson, R.A., Jeejeebhoy K.N. “What is subjective global assessment of nutritional status?” JPEN. Journal of parenteral and enteral nutrition, 11 (1) 8-13. Jan-Feb 1987.
[16]	Erdman, J.W. “Soy protein and cardiovascular disease A statement for healthcare professionals from the nutrition committee of the AHA,” Circulation, 102(2). 2555-9. Nov 2000.
[17]	Reynolds, K., Chin, A., Lees, K.A., Nguyen, A., Bujnowski, D., He, J. “A meta-analysis of the effect of soy protein supplementation on serum lipids,” American Journal of Cardiology, 98 (5). 633-40. Sep 2006.
[18]	Giacco, R., Parillo, M., Rivellese, A.A., Lasorella, G., Giacco, A., D’Episcopo, Riccardi, G. “Long-term dietary treatment with increased amounts of fiber-rich low-glycemic index natural foods improves blood glucose control and reduces the number of hypoglycemic events in type 1 diabetic patients,” Diabetes Care 23(10). 1461-66. Oct 2000.
[19]	Villareal, D.T., Banks, M., Sinacore, D.R., Siener, C., Klein, S. Effect of weight loss and exercise on frailty in obese older adults. Arch Intern Med, 166(8).860-866. Apr 2006
[20]	Villareal, D.T., Chode, S., Parimi, N., Sinacore, D.R., Hilton, T., Armamento-Villareal, R., Napoli, N., Qualls, C., Shah, K. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med, 364(13).1218-1229. Mar 2011.