Journal of Food and Nutrition Research
ISSN (Print): 2333-1119 ISSN (Online): 2333-1240 Website: https://www.sciepub.com/journal/jfnr Editor-in-chief: Prabhat Kumar Mandal
Open Access
Journal Browser
Go
Journal of Food and Nutrition Research. 2022, 10(2), 81-87
DOI: 10.12691/jfnr-10-2-1
Open AccessReview Article

Structurally Diverse Flavonoids from Citrus medica L. Var. sarcodactylis Swingle and Their Multiple Bioactivities: A Review

Jie Chen1, Guang Wu1, Caiqing Zhu2, Yongzhong Wu3, Rongrui Wei1, and Qinge Ma1,

1Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004 China

2Laboratory of Natural Pharmaceutical Chemistry, Jiangxi Medical Device Testing Center, Nanchang, 330029 China

3Jiangxi Puzheng Pharmaceutical Co., Ltd., Jinggangshan, 331400 China

Pub. Date: January 14, 2022

Cite this paper:
Jie Chen, Guang Wu, Caiqing Zhu, Yongzhong Wu, Rongrui Wei and Qinge Ma. Structurally Diverse Flavonoids from Citrus medica L. Var. sarcodactylis Swingle and Their Multiple Bioactivities: A Review. Journal of Food and Nutrition Research. 2022; 10(2):81-87. doi: 10.12691/jfnr-10-2-1

Abstract

Citrus medica L. var. sarcodactylis Swingle is the fruit of Citrus L., which belongs to the Rutaceae family. It has the effects of soothing liver and regulating qi, relieving pain in stomach, drying dampness and resolving phlegm in the clinical aspect of traditional Chinese medicine. There are many kinds of chemical components in C. medica L. var. sarcodactylis Swingle, which mainly including flavonoids, coumarins, alkaloids, volatile oils and other compounds. With the continuous in-depth study of C. medica L. var. sarcodactylis Swingle at home and abroad, it is gradually determined that flavonoids are the important material basis for its pharmacological effect. In order to further clarify the chemical structure characteristics and pharmacological activities of flavonoids in C. medica L. var. sarcodactylis Swingle, the chemical components and pharmacological effects of flavonoids reported in recent years are reviewed, which provide reference for the in-depth study of flavonoids in C. medica L. var. sarcodactylis Swingle.

Keywords:
Citrus medica L. var. sarcodactylis Swingle flavonoids chemical components pharmacological activities

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  Li, W. D. – Liao, S. W. – Wei, Y.: Extraction technology of the main active constituents of flavonoid glycosides from fruits of Citrus medica L. var. sarcodactylis Swingle. Lishizhen Medicine and Materia Medica Research, 30, 2019, pp. 1569-1571.
 
[2]  Chen, Z. Y. – Wang, Y. J. – Xu, Q. Y. – Han, X. X. – Hu, Q. M. – Yang, L. – Chen, E. R. – Liao, F. L. – Guo, W. D.: CmsCRC is involved in regulated fingers stretch in Citrus medica L. var. sarcodactylis Swingle and activated under lower temperature. Acta Horticulturae Sinica, 46, 2019, pp. 2143-2154.
 
[3]  Xu, R. – Zhong, F. L. – Wang, S. B.: Herbal textual research on Citrus medica L. var. sarcodactylis Swingle. Journal of Chinese Medicinal Materials, 40, 2017, pp. 1975-1978.
 
[4]  Zhang, S. D. – Yang, H. Y. – Zeng, J. – Li, M.: Research progress on fruits from Citrus medica L. var. sarcodactylis Swingle. China Journal of Traditional Chinese Medicine and Pharmacy, 33, 2018, pp. 3510-3514.
 
[5]  National Pharmacopoeia Committee. Pharmacopoeia of the people's Republic of China (Part I). Beijing: Chemical Industry Press, 2015, pp.178-179.
 
[6]  He, Y. F. – Jin, X. L.: Review of research progress in Citrus medica L. var. sarcodactylis Swingle with reference to prediction of development prospects. Economic Forest Researches, 19, 2001, pp. 42-43.
 
[7]  Zhang, Y. – Kong, L. Y.: Studies on the constituents of Citrus medica L. var. sarcodactylis Swingle. Modern Chinese Medicine, 8, 2006, pp. 16-17.
 
[8]  Zhao, X. L.: Research progress of physiologically active compounds of bergamot. Science and Technology of Food Industry 33, 2012, pp. 393-399.
 
[9]  Yue, L. – Cheng, X. X. – Tang, X. M. – Yang, Q.: Traditional application of Citrus medica L. var. sarcodactylis Swingle. Chinese Journal of Experimental Traditional Medical Formulae, 25, 2019, pp. 206-211.
 
[10]  Zhang, N.: Application of Citrus medica L. var. sarcodactylis Swingle developed into the health food. Shandong Chemical Industry, 45, 2016, pp. 51-52.
 
[11]  Ou, G. H. – Rang, Y. F. – Huang, Z. Q. – Liu, C. H.: Research progress on chemical constituents and biological activities of Citrus medica L. var. sarcodactylis Swingle extract. Food Science and Technology, 46, 2021, pp. 169-174.
 
[12]  Xia, Y. – Wang, Y. S. – Zhang. Y. J. – Wang, J.: Determination on the basic nutrient components, active ingredients of bergamot fruit and study on their reducing blood lipids function. Food Science and Technology, 41, 2016, pp. 70-73.
 
[13]  Zhong, Y. M. – Tian, Q. L. – Xiao, H. W. – Feng, Y. F.: Chemical constituents of fruits from Citrus medica L. var. sarcodactylis Swingle of different places. Central South Pharmacy, 12, 2014, pp. 63-66.
 
[14]  Yan, W.: Research Progress on chemical constituents and pharmacological effects of Citrus medica L. var. sarcodactylis Swingle. Journal of Practical Traditional Chinese Medicine, 31, 2015, pp. 788-790.
 
[15]  Falé, P. L. – Borges, C. – Madeira, P. J. A. – Ascensão, L. – Araújo, M. E. M. – Florêncio, M. H. – Serralheiro, M. L. M.: Rosmarinic acid, scutellarein 40-methyl ether 7-O-glucuronide and (16S)-coleon Eare the main compounds responsible for the antiacetylcholinesterase and antioxidant activity in herbal tea of Plectranthus barbatus (“falso boldo”). Food Chemistry, 114, 2009, pp. 798-805.
 
[16]  Luo, X. G. – Wang, J. – Chen, H. Q. – Zhou, A. M. – Song, M.Y. – Zhong, Q. P. – Chen, H. M. – Cao, Y.: Identification of flavoanoids from finger Citron and evaluation on their antioxidative and antiaging activities. Frontiers in Nutrition, 7, 2020, pp. 584900.
 
[17]  Gattuso, G. – Aristi, C. – Gargiulli, C. – Bellocco, E. – Toscano, G. – Leuzzi, U.: Flavonoid glycosides in Bergamot juice (Citrus bergamia Risso). Journal of Agricultural and Food Chemistry, 54, 2006, pp. 3929-3935.
 
[18]  Chu, J. – Li, S. L. – Yin, Z. Q. – Ye, W. C. – Zhang, Q. W.: Simultaneous quantification of coumarins, flavonoids and limonoids in fructus Citri Sarcodactylis by high performance liquid chromatography coupled with diode array detector. Journal of Pharmaceutical and Biomedical Analysis, 66, 2012, pp. 170-175.
 
[19]  Gardana, C. – Nalin, F. – Simonetti, P.: Evaluation of flavonoids and furanocoumarins from Citrus bergamia (Bergamot) juice and identification of newcompounds. Molecules, 13, 2008, pp. 2220-2228.
 
[20]  Salerno, R. – Casale, F. – Calandruccio, C. – Procopio, A.: Characterization of flavonoids in Citrus bergamia (Bergamot) polyphenolic fraction by liquid chromatography-high resolution mass spectrometry (LC/HRMS). PharmaNutrition, 4, 2016, pp. 1-7.
 
[21]  Russo, M, – Arigo, A. – Calabro, M. L. – Farnetti, S. – Mondello, L. – Dugo, P.: Bergamot (Citrus bergamia Risso) as a source of nutraceuticals: Limonoids and flavonoids. Journal of Functional Foods, 20, 2016, pp. 10-19.
 
[22]  Yin, F. – Cheng, L. – Lou, F.C: Study on chemical constituents of Citrus medica L. var. sarcodactylis Swingle. Chinese Journal of Natural Medicines, 2, 2004, pp. 149-151.
 
[23]  He, H.Y. – Leng, L. Q. – Shi, G. P. – Zhang, N. – Mao, Q. M.: Study on chemical constituents of Citrus medica L. var. sarcodactylis Swingle. Traditional Chinese Medicine Journal, 13, 1988, pp. 32-34.
 
[24]  Cui, G. L. – Li, L. Y. – Tan, J. – Zhang, Y.: Analysis and evaluation of eight active ingredients of fruits from Citrus medica L. var. sarcodactylis Swingle from different regions. Natural Product Research and Development, 31, 2019, pp. 250-260.
 
[25]  Nogata, Y. – Sakamoto, K. – Shiratsuchi, H. – Ishii, T. – Yano, M. – Ohta, H.: Flavonoid composition of fruit tissues of Citrus species. Bioscience, Biotechnology, & Biochemistry, 70, 2006, pp. 178-192.
 
[26]  Gong, Z. – Gong, L. – Lv, P. Y. – Zhang, J. M. – Zhang, C. Y. – Dong, C. J. – Luo, M. – Zhang, J.: The effect of total flavonoids from Citrus medica L. var. sarcodactylis Swingle on blood lipid and atherosclerosis relatived risk factors in hyperlipidemia rabbits. Chinese Journal of Microcirculation, 26, 2016, pp. 14-17.
 
[27]  Zhou, L. Y. – Tian, A. F. – Hu, X. G.: Pharmacological study on glucose and lipid metabolism and regulation of the chemical composition of Citrus medica L. var. sarcodactylis Swingle. Guangdong Chemical Industry, 44, 2017, pp. 146-148.
 
[28]  Miceli, N. – Mondello, M.R. – Monforte, M. T. – Sdrafkakis, V. – Dugo, P. – Crupi M. L. – Taviano, M. F. – Pasquale, R. D. – Trovato, A.: Hypolipidemic effects of Citrus bergamia Risso et Poiteau juice in rats fed a hypercholesterolemic diet. Journal of Agricultural and Food Chemistry, 55, 2007, pp. 10671-10677.
 
[29]  Wilcox, L.J. – Borradaile, N. M. – Dreu, L. E. – Huff, M. W.: Secretion of hepatocyte ApoB is inhibited by the flavonoids, naringenin and hesperetin, via reduced activity and expression of ACAT2 and MTP. Journal of Lipid Research, 42, 2001, pp. 725-734.
 
[30]  Huang, X. M. – Deng, X: Study on separation, purification and antioxidant activity of flavonoids from chuan bergamot. Chemical Research, 28, 2017, pp. 730-739.
 
[31]  Wang, J. – Luo, X. G. – Zhu, Y. W. – Zhang, Y. M. – Huang, K. X. – Chen, H. M. – Xiao, S. R. – Zhou, A. M.: Optimization of extraction process of flavonoids from bergamot and its antioxidative activity in vitro. Science and Technology of Food Industry, 39, 2018, pp. 192-197.
 
[32]  Huang, J. – Chen, C. – Huang, X. M.: Flavonoids from C. medica L. var. sarcodactylis Swingle: ultrasonicly extracting technology and its antioxidation properties. Chinese Agricultural Science Bulletin, 37, 2021, pp. 126-131.
 
[33]  Wang, J.: Studeies on separation, purification and antioxidant activities of total flavonoids from C. medica L. var. sarcodactylis Swingle. The Master's Thesis of South China Agricultural University, 2018, Guangzhou.
 
[34]  Shi, J. J. – Shi B.: Effect of hesperidin on lipid metabolism disorder in hyperlipemia model rats. Acta Chinese Medicine, 31, 2016, pp. 554-557.
 
[35]  Zhao, Y. Y. – Hu, H. W. – Peng, T. – Deng, F. – Xiang, B. C. – Kuang, Y.: Research progress on chemical constituents, pharmacological effects, development and application of bergamot. Lishizhen Medicine and Materia Medica Research, 29, 2018, pp. 2734-2736.