Regulatory Activities from Conjugated Linoleic Acid of p38 Protein in Melanoma Cells

Hyun Woo Kang^1, and Sang Jae Kwak¹

¹Department of Korean Food & Culinary Arts, Youngsan University, Busan, Korea

Cite this paper:
Hyun Woo Kang and Sang Jae Kwak. Regulatory Activities from Conjugated Linoleic Acid of p38 Protein in Melanoma Cells. Journal of Food and Nutrition Research. 2019; 7(3):183-186. doi: 10.12691/jfnr-7-3-1

Abstract

This study investigated the activities of trans10,cis12-conjugated linoleic acid (CLA) were then passed through the p38 in in vitro model. Cell viability, apoptosis, expression of p38 was evaluated using B16 melanoma cells. Our result showed that the trans10,cis12-CLA increased cell apoptosis in melanoma cells. In addition, CLA stimulated the expression of p38 and phosphorylation p38 (p-p38) level using western blotting. The p38 was presumed that the CLA were involved in regulation of apoptosis-related pathway in the melanoma cells signaling pathway. Considering the results obtained, the present study finding that the regulatory activities of trans10,cis12-CLA may be important as a therapeutic target in ameliorating melanoma cells mediated cancer or/and tumor on in vitro model.

Keywords:
conjugated linoleic acid p38 melanoma cells cell apoptosis

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