Salidroside Could Delays Aging by Regulating the Expression of TERT through Wnt/β-Catenin Pathway

Ke Cai¹, Xi Yu², Hongbo Li¹, Jie Zhai¹ and Guanxi Wang^1,

¹Department of General Practice and Radiology, Songshan Hospital of Qingdao University Medical College, Qingdao 266021, China

²Department of Integrate Medicine, The Qingdao Haici Hospital Affiliated to Qingdao University, Qingdao 266023, China

Cite this paper:
Ke Cai, Xi Yu, Hongbo Li, Jie Zhai and Guanxi Wang. Salidroside Could Delays Aging by Regulating the Expression of TERT through Wnt/β-Catenin Pathway. American Journal of Pharmacological Sciences. 2025; 13(1):1-5. doi: 10.12691/ajps-13-1-1

Abstract

This paper attempted to investigate whether salidroside could delay brain hippocampal neuron senescence in mice. Methods The C57/BL6N mice were normally fed to natural aging and then treated with salidroside. The Morris water maze (MWM) test was used to evaluate the behavioral function of mice. HE staining were used to observe neuron damage in the hippocampal tissues of mice. The expression levels of telomerase reverse transcriptase (TERT) were detected by Western blotting. Reslts The results showed that salidroside could improved the cognition of aging mice. Additionally, salidroside improved the pathological changes of hippocampal neurons of aging mice. Western blotting manifested that salidroside could promote the protein expressions of TERT by activating Wnt/β-catenin pathway. Conclusion It is suggestted that salidroside could delay aging of the hippocampal neurons by up-regulating TERT expression through activating Wnt/β-catenin pathway.

Keywords:
salidroside aging telomerase reverse transcriptase Wnt/β-catenin pathway

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