Anticoagulant and Antioxidant Activities of Dracaena arborea Leaves (Wild.) Link

Nwaehujor Chinaka O.^1, , Ode Julius O.², Nwinyi Florence C.² and Madubuike Stella A.³

¹Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Nigeria

²Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Nigeria

³Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

Cite this paper:
Nwaehujor Chinaka O., Ode Julius O., Nwinyi Florence C. and Madubuike Stella A.. Anticoagulant and Antioxidant Activities of Dracaena arborea Leaves (Wild.) Link. American Journal of Biomedical Research. 2013; 1(4):86-92. doi: 10.12691/ajbr-1-4-4

Abstract

The crude methanol extract of Dracaena arborea leaves induced significant (p<0.01) increase in the clotting times of 21 ± 0.54 sec and 25 ± 1.1 sec at 5% and 10% concentrations of the extract respectively compared to the baseline clotting time of 7 ± 0.63 sec for the blood sample. The extract also exhibited potent in vivo and in vitro anticoagulant activities. Increased doses (100 and 200 mg/kg) of the extract, heparin (0.75 and 1.5 mg/kg) and aspirin (1.0 and 2.0 mg/kg) were found to have significantly (p < 0.01) prolonged the mean bleeding times with respect to the baseline in rabbits. However, in thrombin-induced clotting assay, the extract demonstrated a reduced potency compared to heparin. DPPH (1, 1-Diphenyl-2-picrylhydrazyl) and FRAP (Ferric reducing/antioxidant power) spetrophotometric assays revealed that the crude leaf extract possesses appreciable high antioxidant potentials. Dracaena arborea leaves (Wild.) Link could be a source of novel anticoagulant and antioxidant compounds for the management of various hematological disorders.

Keywords:
anticoagulant Dracaena arborea antioxidant clotting time stroke thrombin

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