Global Journal of Surgery
ISSN (Print): 2379-8742 ISSN (Online): 2379-8750 Website: Editor-in-chief: Baki Topal
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Global Journal of Surgery. 2013, 1(3), 37-40
DOI: 10.12691/js-1-3-7
Open AccessArticle

Cognitive and Mental Changes in Patients with Brain Tumor after Surgery

Afsaneh Zarghi1, 2, , Alireza Zali3, Mehdi Tehranidost2, Mohhamadreza Zarindast2 and Farzad Ashrafi4

1Department of Neuroscience, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

2Institute for cognitive science studies (ICSS), Tehran, Iran

3Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

4Department of Neurology, Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Pub. Date: November 21, 2013

Cite this paper:
Afsaneh Zarghi, Alireza Zali, Mehdi Tehranidost, Mohhamadreza Zarindast and Farzad Ashrafi. Cognitive and Mental Changes in Patients with Brain Tumor after Surgery. Global Journal of Surgery. 2013; 1(3):37-40. doi: 10.12691/js-1-3-7


Introduction and objective: the patients with brain tumor are affected with cognitive and mental changes when undergo surgery and need treatment and rehabilitation. The objective of this study is evaluation of the surgery's effect on these impairments. Method and material: the presented cross-sectional study is done on 94 patients with brain tumor and MMSE, Beck depression, and anxiety tests were used for their cognitive and mental evaluation, before and after the surgery. Results: a significant difference were noticed in MMSE, Beck depression, and anxiety tests' scores, before and after the surgery (p<0.000). Conclusions: the surgery can lead into changes on patients' mental and cognitive status and there is a need on evaluation of these impairments before and after surgery, and in case of noticing the treatment and rehabilitation is needed in order to promote the life quality and survival.

cognitive mental surgery brain tumor

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[1]  Heimans JJ, Taphoorn MJ. Impact of brain tumour treatment on quality of life. J Neurol. 2002; 249:955-960.
[2]  Osoba D, Brada M, Prados MD, Yung WK. Effect of disease burden on health-related quality of life in patients with malignant gliomas. Neuro-Oncology. 2000; 2:221-228.
[3]  Mainio A, Hakko H, Niemela A, Tuurinkoski T, Koivukangas J, Rasanen P. The effect of brain tumour laterality on anxiety levels among neurosurgical patients. J Neurol Neurosurg Psychiatry. 2003; 74:1278-1282.
[4]  Cummings JL. Neuropsychiatric manifestations of right hemisphere lesions. Brain Lang. 1997; 57:22-37.
[5]  Gustafsson M, Edvardsson T, Ahlstrom G. The relationship between function, quality of life and coping in patients with low-grade gliomas. Support Care Cancer. 2006; 14:1205-1212.
[6]  Bhat SR, Goodwin TL, Burwinkle TM, et al: Profile of daily life in children with brain tumors: An assessment of health-related quality of life. J Clin Oncol, 2005 23:5493-5500,
[7]  Wen PY, Kesari S. Malignant gliomas in adults. New England Journal of Medicine 2008; 359:492-507.
[8]  Meyers CA, Hess KR, Yung WK, Levin VA. Cognitive function as a predictor of survival in patients with recurrent malignant glioma. J Clin Oncol. 2000; 18:646-650.
[9]  Weitzner MA, Meyers CA, Gelke CK, Byrne KS, Cella DF, Levin VA. The Functional Assessment of Cancer Therapy (FACT) scale. Development of a brain subscale and revalidation of the general version (FACT-G) in patients with primary brain tumors. Cancer. 1995; 75:1151-1161
[10]  Mainio A, Hakko H, Niemela A, Koivukangas J, Rasanen P. Gender difference in relation to depression and quality of life among patients with a primary brain tumor. Eur Psychiatry 2006; 21:194-9.
[11]  Mainio A, Hakko H, Timonen M, Niemela A, Koivukangas J, Rasanen P. Depression in relation to survival among neurosurgical patients with a primary brain tumor: a 5-year follow-up study. Neurosurgery 2005;56: 1234-41 (discussion 1241-2).
[12]  North CA, North RB, Epstein JA, Piantadosi S, Wharam MD. Lowgrade cerebral astrocytomas. Survival and quality of life after radiation therapy. Cancer 1990; 66:6-14.
[13]  Litofsky NS, Farace E, Anderson F Jr, Meyers CA, Huang W, Laws ER Jr; Glioma Outcomes Project Investigators. Depression in patients with high-grade glioma: results of the Glioma Outcomes Project. Neurosurgery 2004; 54:358-366
[14]  Litofsky, N., Scott, M., Farace, E., Anderson, F., Meyer, C. & Huang, W. Depression in patients with high - grade glioma: results of the Glioma Outcomes Project. Journal of Neurosurgery, Vol 54, Issue 2, 2004; p. 358-367.
[15]  Sheline, G.E., Warra, W. & Smith, V. Therapeutic irradiation and brain injury. International Journal of Radiation Oncology and Biological Physics, 1980; 6, 1215-1228.
[16]  Irle E, Peper M, Wowra B, Kunze S. Mood changes after surgery for tumors of the cerebral cortex. Arch Neurol 1994; 51:164-174
[17]  Giovagnoli AR, Tamburini M, Boiardi A. Quality of life in brain tumor patients. J Neurooncol. 1996; 30:71-80.
[18]  Kaplan CP, Miner ME. Relationships: importance for patients with cerebral tumours. Brain Inj. 2000; 14:251-259.
[19]  Arnold SD, Forman LM, Brigidi BD, et al. Evaluation and characterization of generalized anxiety and depression in patients with primary brain tumors. Neuro-Oncology. 2008; 10:171-181.
[20]  Folstein, M., Folstein, S.E., McHugh, P.R.. “Mini-Mental State” a Practical Method for Grading the Cognitive State of Patients for the Clinician. Journal of Psychiatric Research, 1975; 12(3); 189-198.
[21]  Beck AT, Ward CH, Mendelson M, et al. An inventory for measuring depression. Arch Gen Psychiatry 1961; 4:61-571.
[22]  Hedlund JL, Viewig BW (1979) The Hamilton rating scale for depression: a comprehensive review. Journal of Operational Psychiatry 10:149-165.
[23]  Cynthia A, Riccio, Cecil R., Reynolds, Lowe P, Jennifer J, Moore. (2002). The continuous performance test: a window on the neural substrates for attention? Archives of Clinical Neuropsychology, 17: 235-272.