Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO₂

Fateh Eltaboni^1, , Amira Alhodeary¹, Mona Ibrahim¹, Fawzia Ali¹, Aya Al Abdali¹, Nadin Al Farsi¹, Fatma Elshibani² and Mohamed Ali Sharkasi³

¹Chemistry Department, University of Benghazi, Benghazi, Libya

²Pharmacognosy Department, University of Benghazi, Benghazi, Libya

³Pharmaceutical Chemistry Department, University of Benghazi, Benghazi, Libya

Cite this paper:
Fateh Eltaboni, Amira Alhodeary, Mona Ibrahim, Fawzia Ali, Aya Al Abdali, Nadin Al Farsi, Fatma Elshibani and Mohamed Ali Sharkasi. Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO₂. Journal of Polymer and Biopolymer Physics Chemistry. 2020; 8(1):15-27. doi: 10.12691/jpbpc-8-1-2

Abstract

Mixing potato starch (PSS) with sodium starch glycolate (SSG) and silica nanoparticles (SiO₂) substantially controls its swelling and mechanical behavior. Therefore, starch-starch glycolate-based delivery systems may be suitable for regulated model drug delivery. This work aimed to examine the release of dye from starch micro-particles and films as a mimic study for the drug release from an excipient. Starch film was prepared in vitro using glycerol as a plasticizing agent in aqueous gelatinous solution containing different amounts of SSG in the presence and absence of SiO₂. UV-vis spectroscopic technique was used to investigate the release kinetics of a model drug-like compound (Crystal violet, CV) in phosphate buffer solution (PBS) pH 7.4 at 37 ^oC. The swelling and folding strength of films have showed the different sensitivities of the films to SSG content and incorporation of SiO₂. It has been determined that SSG's cross-linking capability plays a critical role in starch's mechanical and rheological properties. Release of cationic drug across the polymeric films was significantly higher than that of the physical mixtures of CV in PSS-SSG microparticles. A higher release percentage was detected for PSE-Si-CV than that of PSE-Si-CV-SSG_1%. The mechanism for the release of drugs was found to obey quasi-Fickian and non-Fickian diffusion mechanism for the PSS-Si-CV and PSS-Si-CV-SSG_1% films.

Keywords:
starch films microparticles mechanical properties crystal violet release

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