Journal of Polymer and Biopolymer Physics Chemistry
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Journal of Polymer and Biopolymer Physics Chemistry. 2020, 8(1), 15-27
DOI: 10.12691/jpbpc-8-1-2
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Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO2

Fateh Eltaboni1, , Amira Alhodeary1, Mona Ibrahim1, Fawzia Ali1, Aya Al Abdali1, Nadin Al Farsi1, Fatma Elshibani2 and Mohamed Ali Sharkasi3

1Chemistry Department, University of Benghazi, Benghazi, Libya

2Pharmacognosy Department, University of Benghazi, Benghazi, Libya

3Pharmaceutical Chemistry Department, University of Benghazi, Benghazi, Libya

Pub. Date: July 12, 2020

Cite this paper:
Fateh Eltaboni, Amira Alhodeary, Mona Ibrahim, Fawzia Ali, Aya Al Abdali, Nadin Al Farsi, Fatma Elshibani and Mohamed Ali Sharkasi. Model Drug Release from Potato Starch-Starch Glycolate Microparticles and Films with and without Incorporated Nano-SiO2. Journal of Polymer and Biopolymer Physics Chemistry. 2020; 8(1):15-27. doi: 10.12691/jpbpc-8-1-2


Mixing potato starch (PSS) with sodium starch glycolate (SSG) and silica nanoparticles (SiO2) substantially controls its swelling and mechanical behavior. Therefore, starch-starch glycolate-based delivery systems may be suitable for regulated model drug delivery. This work aimed to examine the release of dye from starch micro-particles and films as a mimic study for the drug release from an excipient. Starch film was prepared in vitro using glycerol as a plasticizing agent in aqueous gelatinous solution containing different amounts of SSG in the presence and absence of SiO2. UV-vis spectroscopic technique was used to investigate the release kinetics of a model drug-like compound (Crystal violet, CV) in phosphate buffer solution (PBS) pH 7.4 at 37 oC. The swelling and folding strength of films have showed the different sensitivities of the films to SSG content and incorporation of SiO2. It has been determined that SSG's cross-linking capability plays a critical role in starch's mechanical and rheological properties. Release of cationic drug across the polymeric films was significantly higher than that of the physical mixtures of CV in PSS-SSG microparticles. A higher release percentage was detected for PSE-Si-CV than that of PSE-Si-CV-SSG1%. The mechanism for the release of drugs was found to obey quasi-Fickian and non-Fickian diffusion mechanism for the PSS-Si-CV and PSS-Si-CV-SSG1% films.

starch films microparticles mechanical properties crystal violet release

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[1]  Priya, B., Gupta, V. K., Pathania, D. and Singha, A. S., ''Synthesis, characterization and antibacterial activity of biodegradable starch/pva composite films reinforced with cellulosic fibre,''. Carbohydrate polymers, 109. 171-179. 2014.
[2]  Bayor, M., Tuffour, E. and Lambon, P., ''Evaluation of starch from new sweet potato genotypes for use as a pharmaceutical diluent, binder or disintegrant,'' Journal of applied pharmaceutical science, 3. S17-S23. 2013.
[3]  Imam, S. H., ''Stuck on starch: a new wood adhesive,'' Agricultural research magazine, 48. 1-9. 2000.
[4]  Krishnan, P. G., Julson, J. L., Robison, D. J. and Pathak Y. V., ''Polyethylene-starch extrudates as erodible carriers for bioactive materials: I. Erodibility and in vitro dye release studies,'' Journal of biomaterials applications, 8. 285-297. 1994.
[5]  Ojogbo, E., Ogunsona, E. O. and Mekonnen, T. H., ''Chemical and physical modifications of starch for renewable polymeric materials,'' Materials today sustainability, 100028. 2019.
[6]  Passaretti, M., Ninago, M., Paulo, C., Petit, H., Irassar, E., Vega, D., Villar M. and Lez, O. V., ''Biocomposites based on thermoplastic starch and granite sand quarry waste,'' Journal of renewable materials, 7. 393-402. 2019.
[7]  Shahriari, T. and NabiBidhendi, G., ''Starch efficiency in water turbidity removal,'' Asian journal of natural & applied sciences, 1. 34-37. 2012.
[8]  Shalviri, A., Liu, Q., Abdekhodaie, M. J. and Wu. X. Y., ''Novel modified starch-xanthan gum hydrogels for controlled drug delivery: Synthesis and characterization,'' Carbohydrate polymers, 79. 898-907. 2010.
[9]  Silva, O. A., Pellá, M. G., Pellá, M. G., Caetano, J., Simões, M. R., Bittencourt, P. R. S. and Dragunski, D. C., ''Synthesis and characterization of a low solubility edible film based on native cassava starch,'' International journal of biological macromolecules, 128. 290-296. 2019.
[10]  Spychaj, T., zdanowicz, M., kujawa, J. And Schmidt, B., ''Carboxymethyl starch with high degree of substitution synthesis, properties and application,'' Polimery, 58. 501-630. 2013.
[11]  Suderman, N., Sarbon, N. and Mohamad Isa, M. I. N., ''Effect of drying temperature on the functional properties of biodegradable cmc-based film for potential food packaging,'' International food research journal, 23. 1075-1084. 2016.
[12]  Kim, M. and Pometto 3rd, A. L., ''Food packaging potential of some novel degradable starch-polyethylene plastics (1),'' Journal of food protection, 57. 1007-1012. 1994.
[13]  Belay, Z. and Emire, S., ''Development and characterization of antimicrobial packaging films,'' Journal of food processing and technology, 4. 000235. 2013.
[14]  Sadeghizadeh-Yazdi, J., Habibi, M., Kamali, A. and Banaei, M., ''Application of edible and biodegradable starch-based films in food packaging: A systematic review and meta-analysis,'' Current research in nutrition and food science journal, 7. 624-637. 2019.
[15]  Lawton, J. W., ''Effect of starch type on the properties of starch containing film,'' Carbohydrate polymers, 29. 203-208. 1996.
[16]  Mehyar, G. and Han, J., ''Physical and mechanical properties of high‐amylose rice and pea starch films as affected by relative humidity and plasticizer,'' Journal of food science, 69. E449-E454. 2006.
[17]  Zhang, S., Wei, F. and Han, X., ''An edible film of sodium alginate/pullulan incorporated with capsaicin,'' New journal of chemistry, 42. 17756-17761. 2018.
[18]  Rosseto, M., Krein, D., Balbé, N. and Dettmer, A., ''Starch‐gelatin film as an alternative to the use of plastics in agriculture - a review,'' Journal of the science of food and agriculture, 99. 2019.
[19]  Chang, Q., Hao, Y., Cheng, L., Liu Y. and Qu, A., ''Preparation and performance evaluation of biodegradable corn starch film using poly (lactic acid) as waterproof coating,'' Surface engineering, 1-6. 2019.
[20]  Huo, W., Xie, G., Zhang, W., Wang, W., Shan, J., Liu, H. and Zhou, X., ''Preparation of a novel chitosan-microcapsules/starch blend film and the study of its drug-release mechanism,'' International journal of biological macromolecules, 87. 114-122. 2016.
[21]  Ismail, H. and Zaaba, N. F., ''The mechanical properties, water resistance and degradation behaviour of silica-filled sago starch/pva plastic films,'' Journal of elastomers & plastics, 46. 96-109. 2012.
[22]  Krogars, K., Heinämäki, J., Karjalainen, M., Niskanen, A., Leskelä, M. and Yliruusi, J., ''Enhanced stability of rubbery amylose-rich maize starch films plasticized with a combination of sorbitol and glycerol,'' International journal of pharmaceutics, 251. 205-8. 2003.
[23]  Tang, H., Xiong, H., Tang, S. and Zou, P., ''A starch-based biodegradable film modified by nano silicon dioxide,'' Journal of applied polymer science, 113. 34-40. 2009.
[24]  Wolff I., A., Davis, H. A., Cluskey, J. E., Gundrum L. J. and Rist, C. E., ''Preparation of films from amylose,'' Industrial & engineering chemistry, 43. 915-919. 1951.
[25]  Rankin, J., Wolff, I., Davis, H. and Rist, C., ''Permeability of amylose film to moisture vapor, selected organic vapors, and the common gases,'' Industrial & engineering chemistry chemical & engineering data series, 3. 120-123. 1958.
[26]  Zhang, R., Wang, X. and Cheng, M., ''Preparation and characterization of potato starch film with various size of nano-SiO2,'' Polymers, 10. 1172. 2018.
[27]  And, Z. and Han, J., ''Film-forming characteristics of starches,'' Journal of food science, 70. E31-E36. 2005.
[28]  López, O. V., Ninago, M. D., Lencina, M. M. S., García, M. A., Andreucetti, N. A., Ciolino, A. E. and Villar, M. A., ''Thermoplastic starch plasticized with alginate-glycerol mixtures: Melt-processing evaluation and film properties,'' Carbohydrate polymers, 126. 83-90. 2015.
[29]  Perry, P. A. and Donald, A., ''The role of plasticization in starch granule assembly,'' Biomacromolecules, 1. 424-32. 2000.
[30]  Bertuzzi, M., Gottifredi, J. and Armada, M., ''Mechanical properties of a high amylose content corn starch based film, gelatinized at low temperature,'' Brazilian journal of food technology, 15. 219-227. 2012.
[31]  Rahmah, M., Mohd, N., Norizan. M. N., Aisyah, M. and Fauzi, F., ''Swelling and tensile properties of starch glycerol system with various crosslinking agents,'' IOP conference series: materials science and engineering, 223. 012059. 2017.
[32]  Zavareze, E., Zanella, Pinto, V., Klein, B., Halal, S., Elias, M., Prentice, C. and Dias, Á., ''Development of oxidised and heat-moisture treated potato starch film,'' Food chemistry, 132. 2011.
[33]  Shogren, R. L., Greene, R. V. and WU, Y. V., ''Complexes of starch polysaccharides and poly(ethylene co-acrylic acid): Structure and stability in solution,'' Journal of applied polymer science, 42. 1701-1709. 1991.
[34]  Sarwono, A., Man, Z., Bustam, M. A., Subbarao, D., Idris, A., Muhammad, N., Khan, A. S. and Ullah, Z., ''Swelling mechanism of urea cross-linked starch-lignin films in water,'' Environmental technology, 39. 1522-1532. 2018.
[35]  Suriyatem, R., Auras, R. A. and Rachtanapun, P., ''Improvement of mechanical properties and thermal stability of biodegradable rice starch-based films blended with carboxymethyl chitosan,'' Industrial crops and products, 122. 37-48. 2018.
[36]  Almasia, H., Ghanbarzadeha, B. and Entezami, A. A., ''Physicochemical properties of starch-cmc-nanoclay biodegradable films,'' International journal of biological macromolecules, 46. 1-5. 2010.
[37]  Sheskey, P. J., Cook, W. G. and Cable, C. G., Handbook of pharmaceutical excipients, Pharmaceutical Press, London, 2017.
[38]  Xie J., Luo, Y., Liu, Y., Ma, Y., Yue, P. and Yang, M., ''Novel redispersible nanosuspensions stabilized by co-processed nanocrystalline cellulose-sodium carboxymethyl starch for enhancing dissolution and oral bioavailability of baicalin,'' International journal of nanomedicine, 14. 353-369. 2019.
[39]  Eltaboni, F. and Imragaa, A., ''Physical and chemical modifications of starches,'' In 'proceeding of 2nd Libyan conference on chemistry and its applications, 1. 120-123. 2017.
[40]  Eltaboni, F., Caseley, E., Katsikogianni, M., Swanson, L., Swift, T. and Romero-Gonzalez, M., ''Fluorescence spectroscopy analysis of the bacteria-mineral interface: Adsorption of lipopolysaccharides to silica and alumina,'' Langmuir, 36, 1623-1632. 2020.
[41]  Eltaboni, F., Imragaa, A., Alzintani, W. and Almograbi, H., ''Kinetic study of macromolecular interaction of starch onto silica nanoparticles,'' In 'proceeding of 2nd Libyan conference on chemistry and its applications, 2. 87-89. 2018.
[42]  Eltaboni, F., Imragaa, A., Edbey, K., Elabdily, K. and Mousa, N., ''Adsorption and conformations of starch at solid-liquid interfaces using spectrophotometry and turbidity techniques,'' American chemical science journal, 9.1-11. 2015.
[43]  Tang, H., Xiong, H., Tang, S. and Zou, P., ''A starch-based biodegradable film modified by nano silicon dioxide,'' Journal of applied polymer science, 113. 34-40. 2009.
[44]  Shi, X., Hassanzadeh-Aghdam, M. K. and Ansari, R., ''Viscoelastic analysis of silica nanoparticle-polymer nanocomposites,'' Composites part B: engineering, 158. 169-178. 2019.
[45]  Yang, J., Han, C., Duan, J.-F., Xu, F. and Sun, R.-C., ''Interaction of silica nanoparticle/polymer nanocomposite cluster network structure: revisiting the reinforcement mechanism,'' The journal of physical chemistry C, 117. 8223-8230. 2013.
[46]  Xie, Y., Yan, M., Yuan, S., Sun, S. and Huo, Q. J. C. C. J., ''Effect of microwave treatment on the physicochemical properties of potato starch granules,'' Chemistry central journal, 7. 1-7. 2013.
[47]  Wuttisela, K., Shobsngob, S. and Triampo, W., ''Amylose/amylopectin simple determination in acid hydrolyzed tapioca starch,'' Journal of the chilean chemical society - J CHIL CHEM SOC, 53. 1565-1567. 2008.
[48]  Jonhed, A. and Järnström, L., ''Phase and gelation behavior of 2-hydroxy-3-(n, n-dimethyl-n-dodecylammonium) propyloxy starches,'' Starch / stärke, 55. 569-575. 2003.
[49]  Wyatt, P. J., ''Measurement of special nanoparticle structures by light scattering,'' Analytical chemistry, 86. 7171-7183. 2014.
[50]  Sinko, P. J. and Martin, A. N., Martin's physical pharmacy and pharmaceutical sciences: Physical chemical and biopharmaceutical principles in the pharmaceutical sciences, Lippincott Williams & Wilkins, Philadelphia, 2006.
[51]  Obitte, N. and Chukwu, A., ''Preliminary studies on tacca involucrata (schum & thonn) starch. Fam_ taccaceae,'' West african journal of pharmacy, 20. 8-13. 2007.
[52]  Koc, B., Sakin-Yilmazer, M., Kaymak-Ertekin, F. and Balkir, P., ''Physical properties of yoghurt powder produced by spray drying,'' Jouranl of food science and technolgy, 51. 1377-1383. 2014.
[53]  Carr, R. L., ''Evaluating flow properties of solids Chemical,'' Engineering, 72. 163-168. 1965.
[54]  Souza, A. C., Benze, R., Ferrão, E. S., Ditchfield, C., Coelho, A. C. V. and Tadini, C. C., ''Cassava starch biodegradable films: Influence of glycerol and clay nanoparticles content on tensile and barrier properties and glass transition temperature,'' LWT - food science and technology, 46. 110-117. 2012.
[55]  de Moraes, J. O., Müller, C. M. O. and Laurindo, J. B., ''Influence of the simultaneous addition of bentonite and cellulose fibers on the mechanical and barrier properties of starch composite-films,''Food science and technology international, 18. 35-45, 2012.
[56]  Zayed, G. M., Rasoul, S. A.-E., Ibrahim, M. A., Saddik, M. S. and Alshora, D. H.: ''In vitro and in vivo characterization of domperidone-loaded fast dissolving buccal films,'' Saudi pharmaceutical journal, 28. 266-273. 2020.
[57]  Nair, S. B. and Jyothi, A. N., ''Cassava starch-konjac glucomannan biodegradable blend films: In vitro study as a matrix for controlled drug delivery,'' Starch/stärke, 65. 273-284. 2013.
[58]  Dash, S., Murthy, P. N., Nath, L. and Chowdhury, P., ''Kinetic modeling on drug release from controlled drug delivery systems,'' Acta poloniae pharmaceutica, 67. 217-23. 2010.
[59]  Baishya, H., ''Application of mathematical models in drug release kinetics of carbidopa and levodopa er tablets,'' Journal of developing drugs, 06. 2017.
[60]  Onunkwo, G. and Onyishi, I., ''Kinetics and mechanisms of drug release from swellable and non swellable matrices: A review,'' Research journal of pharmaceutical, biological and chemical sciences, 4. 97-103. 2013.
[61]  Olejnik, A., Kapuscinska, A., Schroeder, G. and Nowak I., ''Physico-chemical characterization of formulations containing endomorphin-2 derivatives,'' Amino acids, 49. 1719-1731. 2017.
[62]  Paarakh, M. P., Jose, P. A., Setty, C. and Christoper P., ''Release kinetics-concepts and applications,'' International journal of pharmacy research & technology, 10. 1-9. 2018.
[63]  Theisen, A., Johann, C., Deacon, M. P. and Harding S. E., Refractive increment data-book for polymer and biomolecular scientists, Nottingham University Press, Nottingham, 2000.
[64]  Stojanović, Ž. P., Jeremić, K., Jovanović, S., Nierling, W. and Lechner, M. D., ''Light scattering and viscosity investigation of dilute aqueous solutions of carboxymethyl starch,'' Starch/stärke, 61. 199-205. 2009.
[65]  Commission, B. P.: British pharmacopoeia 2007. Stationery Office, 2006.
[66]  Bonsu, M. A., Ofori-Kwakye, K., Kipo, S. L., Boakye-Gyasi, M. E. and Fosu M.-A., ''Development of oral dissolvable films of diclofenac sodium for osteoarthritis using albizia and khaya gums as hydrophilic film formers,'' Journal of drug delivery, 2016. 6459280. 2016.
[67]  Wahyuningtyas, D. and Dinata A., ''Combination of carboxymethyl cellulose (cmc) - corn starch edible film and glycerol plasticizer as a delivery system of diclofenac sodium,'' In 'AIP conference proceedings' 1977, 030032-1-030032-8. 2018.
[68]  Wilpiszewska, K., ''Hydrophilic films based on starch and carboxymethyl starch,'' Polish journal of chemical technology, 21. 26-30. 2019.
[69]  Semalty, A., Semalty, M., Nautiyal, U., ''Formulation and evaluation of mucoadhesive buccal films of enalapril maleate,'' Indian journal of pharmaceutical sciences, 72. 571-575. 2010.
[70]  Al-Kadhemy, M., ''Absorption spectrum of crystal violet in chloroform solution and doped PMMA thin films,'' Atti della fondazione giorgio ronchi, 3. 359. 2012.
[71]  Amiri, M. J., ''Optimization of crystal violet adsorption by chemically modified potato starch using response surface methodology,'' Pollution, 6. 159-170. 2020.
[72]  Lin, J., Li D., Chen, P., Wang, J. and Xu, S., ''Interaction between carboxymethyl starch and cetyl trimethylammonium bromide,'' Chemistry bulletin / huaxue tongbao, 74. 1131-1134+1139. 2011.
[73]  Yue, Y.-M., Xu K., Liu, X.-G., Chen, Q., Sheng, X. and Wang, P.-X., ''Preparation and characterization of interpenetration polymer network films based on poly(vinyl alcohol) and poly(acrylic acid) for drug delivery,'' Journal of applied polymer science, 108. 3836-3842. 2008.