Fateh Eltaboni^1,, Amira Alhodeary¹, Mona Ibrahim¹, Fawzia Ali¹, Aya Al Abdali¹, Nadin Al Farsi¹, Fatma Elshibani², Mohamed Ali Sharkasi³

Mixing potato starch (PSS) with sodium starch glycolate (SSG) and silica nanoparticles (SiO₂) substantially controls its swelling and mechanical behavior. Therefore, starch-starch glycolate-based delivery systems may be suitable for regulated model drug delivery. This work aimed to examine the release of dye from starch micro-particles and films as a mimic study for the drug release from an excipient. Starch film was prepared in vitro using glycerol as a plasticizing agent in aqueous gelatinous solution containing different amounts of SSG in the presence and absence of SiO₂. UV-vis spectroscopic technique was used to investigate the release kinetics of a model drug-like compound (Crystal violet, CV) in phosphate buffer solution (PBS) pH 7.4 at 37 ^oC. The swelling and folding strength of films have showed the different sensitivities of the films to SSG content and incorporation of SiO₂. It has been determined that SSG's cross-linking capability plays a critical role in starch's mechanical and rheological properties. Release of cationic drug across the polymeric films was significantly higher than that of the physical mixtures of CV in PSS-SSG microparticles. A higher release percentage was detected for PSE-Si-CV than that of PSE-Si-CV-SSG_1%. The mechanism for the release of drugs was found to obey quasi-Fickian and non-Fickian diffusion mechanism for the PSS-Si-CV and PSS-Si-CV-SSG_1% films.

starch films, microparticles, mechanical properties, crystal violet, release