[1] | Watson, J. “Oxidants, antioxidants and the current incurability of metastatic cancers”. Open Biol, 3(1). 120144. Jan. 2013. |
|
[2] | Printz, C. “Is cancer research too conservative? Leaders weigh in on barriers to the fight against cancer”, Cancer, 119(9):1605-6. May. 2013. |
|
[3] | Rahib, L., Smith, B.D., Aizenberg, R., Rosenzweig, A.B., Fleshman, J.M., and Matrisian, L.M. “Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States”, Cancer Res, 74(11): 2913-21. Jun. 2014. |
|
[4] | Hanaha, D. “Rethinking the war on cancer”, Lancet, 383 (9916): 558-63. Feb. 2014. |
|
[5] | World Health Organization (WHO). “Cancer”, http://www.who.int/mediacentre/factsheets/fs297/en. Feb.2014. |
|
[6] | Santana-Blank, L. “Infrared Pulsed Laser Device (IPLD): An apparatus and method for treating Cancer and Complex Systemic Diseases”, United States Patent No. 5,231,984. Aug.1993. http://www.google.com/patents/US5231984. |
|
[7] | Santana-Blank, L.A., Rodríguez-Santana, E., Vargas, F., Reyes, H., Fernández-Andrade, P., Rukos, S., and Santana-Rodríguez, K.E. “Phase I trial of an infrared pulsed laser device in patients with advanced neoplasias”, Clin Cancer Res, 8(10): 3082-3091. Oct. 2002. |
|
[8] | Santana-Blank, L. A., Castes, M., Rojas, M. E., Vargas, F., and Scott-Algara, D. “Evaluation of serum levels of tumor necrosis factor-(TNF-a) and soluble IL-2 receptor (sIL-2R) and CD4. CD8 and natural killer (NK) populations during infrared pulsed laser device (IPLD) treatment”, Clin Exp Immunol, 90(1): 43-48. Oct. 1992. |
|
[9] | Santana-Blank, L.A., Rodríguez-Santana, E., Vargas, F., and Santana-Rodríguez, K.E. “Photo-induced cytomorphologic changes in an advanced cancer phase I clinical trial”, Lasers Surg. & Med, 30(1):18-25. Jan. 2002. |
|
[10] | Santana-Blank, L., Rodríguez-Santana, E., Santana-Rodríguez, J.A., and Santana-Rodríguez, K.E. “Solid tumors and photobiomodulation: A novel approach to induce physiologically reparative homeostasis / homeokinesis-review”, Journal of Solid Tumors, 2(6):23-35. Dec. 2012. |
|
[11] | Santana-Blank, L.A., Reyes, H., Rodríguez-Santana, E., and Santana-Rodríguez, K.E. “Microdensitometry of T2-weighted magnetic resonance (MR) images from patients with advanced neoplasias in a phase I clinical trial of an infrared pulsed laser device (IPLD)”, Lasers Surg &Med, 34 (5):398-406. Jun. 2004. |
|
[12] | Reyes, H., Rodríguez-Santana, E., Santana-Rodríguez, J.A., Santana-Rodríguez, K.E., and Santana-Blank, L. “Decoding the Ice-Water Energy Paradox in the DW-MRI Phantom for Tumors: Targeting Thermodynamics, Kinetic and Structural Molecular Mechanisms. Commentary”, Journal of Cancer Research and Treatment, 2(1): 19-21. April. 2014. |
|
[13] | Myakishev-Rempel,M., Stadler, I., Brondon, P., Axe, D.R., Friedman, M., Nardia, F.B., and Lanzafame, R. “A preliminary study of the safety of red light phototherapy of tissues harboring cancer”, Photomed &Laser Surg, 30(9):551-8. Sep. 2012. |
|
[14] | Zimin, A.A., Zhevago, N.A., Buiniakova, A.I., and Samilova, K.A. “Application of low-power visible and near infrared radiation in clinical oncology”, Vopr. Kurortol. Fizioter. Lech. Fiz. Kult, 6, 49–52. 2009. |
|
[15] | Tanaka, Y., Matsuo, K., Yuzuriha, S., Yan, H., and Nakayama, J. “Non-thermal cytocidal effect of infrared irradiation on cultured cancer cells using specialized device”, Cancer Sci, 101(6):1396-402. Jun. 2010. |
|
[16] | Tata, D.B., and Waynant, R.W. “A comparative study on non-confluent and confluent human malignant brain cancer metabolic response to He-Ne laser exposures: evidence for laser enhanced cellular production of H2O2 and laser induced bystander effect”, Proc. SPIE, 7165, 716508. Feb. 2009. |
|
[17] | Tata, D.B., Fahey, M., Mitra, K., Anders, J., and Waynant, R.W. “Near-IR induced suppression of metabolic activity in aggressive cancers”, Proc. SPIE, 6428, 64280E. Feb. 2007. |
|
[18] | Tata, D.B., and Waynant, R.W. “Laser light induced modulations in metabolic activities in human brain cancer”, Proc. SPIE. 6846, 684607. Mar.2008. |
|
[19] | Santana-Blank, L., Rodríguez-Santana, E., and Santana Rodríguez, K.E. “Concurrence of emerging developments in photobiomodulation and cancer”, Photomed & Laser Surg, 30 (11): 615-6. Nov. 2012. |
|
[20] | Prendergast, G.C. “Perspectives on emerging trends in cancer research”, Cancer Res, 71(6): 2027-2028. Mar.2011. |
|
[21] | Yan, H., Kinjo, T., Tian, H., Hamasaki, T., Teruya, K., Kabayama, S., and Shirahata, S. “Mechanism of the lifespan extension of Caenorhabditis elegans by electrolyzed reduced water--participation of Pt nanoparticles”, Biosci Biotechnol Biochem, 75 (7):1295-9. May. 2011. |
|
[22] | Shirahata, S., Hamasaki, T., and Teruya,K. “Advanced research on the health benefit of reduced water”, Trends in Food Science & Technology, 23(2):124-131. Feb. 2012. |
|
[23] | Nakanishi, H., Hamasaki, T., Kinjo, T., Yan, H., Nakamichi, N., Kabayama, S., Teruya,K., and Shirahata,S. “Low Concentration Platinum Nanoparticles Effectively Scavenge Reactive Oxygen Species in Rat Skeletal L6 Cells”, Nano Biomed. Eng, 5(2), 76-85: 2013. |
|
[24] | McAllister, S.S., and Weinberg, R.A. “The tumor-induced systemic environment as a critical regulator of cancer progression and metastasis”, Nat Cell Biol, 16(8):717-27. Aug. 2014. |
|
[25] | Santana-Blank, L.A., Rodríguez-Santana, E., and Santana-Rodríguez, K.E. “Photo-infrared pulsed bio-modulation (PIPBM): a novel mechanism for the enhancement of physiologically reparative responses”, Photomed & Laser Surg, 23(4):416-24. Aug. 2005. |
|
[26] | Santana-Blank, L., Rodríguez-Santana, E., and Santana-Rodríguez, K. “Theoretic, experimental, clinical bases of the water oscillator hypothesis in near-infrared photobiomodulation”. Photomed & Laser Surg, 28 (S1):S41-52. Aug. 2010. |
|
[27] | Santana-Blank, L., Rodríguez-Santana, E., and Santana-Rodríguez, K.E. “Photobiomodulation of Aqueous Interface as Selective Rechargeable Bio-Batteries in Complex Diseases”, Photomed & Laser Surg, 30(5):242-249. May. 2012. |
|
[28] | Santana-Blank, L., Rodríguez-Santana, E., Santana-Rodríguez, J.A., and Santana-Rodríguez, K.E. “Photobiomodulation of Aqueous Interfaces: Finding Evidence to Support the Exclusion Zone in Experimental and Clinical Studies”, Photomed. & Laser Surg, 31(9): 461-462. Sep. 2013. |
|
[29] | Santana-Blank, L.A., and Rodríguez-Santana, E. “Physiologic rhythms responding to low-level electromagnetic and mechanical signals: the Joule equivalence principle”, Photomed & Laser Surg, 26(4):405-6. Aug. 2008. |
|
[30] | Abrahamse, H. “Regenerative medicine, stem cells, and low-level laser therapy: future directives”, Photomed. & Laser Surg, 30(12): 68-682. Dec. 2012. |
|
[31] | Rodríguez-Santana, E., and Santana Blank, L. “Laser Photobiomodulation as a Potential Multi-Hallmark Therapy for Age- Related Macular Degeneration”, Photomed. & Laser Surg, 32(9): 409-410. Sep. 2013. |
|
[32] | Santana-Blank, L., Rodríguez-Santana, E., Santana-Rodríguez, J.A., Santana-Rodríguez, K.E., and Reyes H. “Water as a photoacceptor, energy transducer and rechargeable electrolytic biobattery in photobiomodulation.” IN: “Handbook of Low Level Laser Light Therapy”. Pan Stanford Publishing Pte. Singapore, In press. |
|
[33] | Rodríguez-Santana, E., Santana-Blank, L.A., Reyes, H., Santana-Rodríguez, K.E., Hunger, M., Orellana, R., and Ortega, D. “H-NMR spin-lattice and correlation times of burned soft-tissue after treatment with an infrared pulsed laser device”, Lasers in Surg &Med, 33(3): 190-8. Sep. 2003. |
|
[34] | Hale, G.M., and Querry, M.R. “Optical Constants of Water in the 200-nm to 200-microm Wavelength Region”, Appl. Opt, 12 (3); 555-563. Mar. 1973. |
|
[35] | Currie, M. “Comparison of optical pulse propagation in water and acetonitrile”, PIERS Online, 4(8): 815-820. 2008. |
|
[36] | Fox, A.E., and Osterberg, U. “Observation of nonexponential absorption of ultra-fast pulses in water”, Optics Express, 14 (8): 3688–3693. Apr. 2006. |
|
[37] | Santana-Blank, L.A.,Rodríguez-Santana,E., Scott-Algara,D., Hunger, M.,Santana-Rodríguez,K.E., and Orellana,R. “Short-Term Bioeffects of an Infrared Pulsed Laser Device on Burned Rat Skin Monitored by Transverse Relaxation Times (NMR)”, Lasers in Surg. & Med, 27(5):411-419. Dic. 2000. |
|
[38] | Meis, J.D. “Surfing a chaotic sea”, Nature, 398(6725): 303 March 1999. |
|
[39] | Wiggins, S. “Transport in k-degree-of-freedom Hamiltonian systems, 3 ≤K<∞ the generalization of separatrices to higher dimensions and their geometrical structure. In: Chaotic Transport in Dynamical Systems”. Springer-Verlag, New York, 1991, 209-271. |
|
[40] | Woutersen, S., and Bakker, H.J. “Resonant intermolecular transfer of vibrational energy in liquid water”, Nature, 402:507-509. Dec. 1999. |
|
[41] | Geissler, P.L., Dellago, C., Chandler, D., Hutter, J., and Parrinello, M. “Autoionization in liquid water”, Science, 291(5511): 212l. Mar. 2001. |
|
[42] | Miller, D.G. “Thermodynamics of irreversible processes. The experimental verification of the Onsager reciprocal relations”, Chem. Rev, 60 (1):15-37. Feb. 1960. |
|
[43] | Rubí, J.M. “The long arm of the second law”, Sci Am, 299(5):62-67. Nov. 2008. |
|
[44] | Nordenström, B.E. “Fleischner lecture. Biokinetic impacts on structure and imaging of the lung: the concept of biologically closed electric circuits”, AJR Am J Roentgenol, 145 (3):447-67. Sep. 1985. |
|
[45] | Santana-Blank, L., Rodríguez-Santana, E., Reyes, H., Santana-Rodríguez, J.A., and Santana-Rodríguez, K.E. “Water-light interaction: A novel pathway for multi hallmark therapy in cancer”, Int J Cancer Ther Oncol, 2(1):02012. Dec.2014. |
|
[46] | Pollack, G.H. The enigma of interfacial water, in: The Fourth Phase of Water: Beyond Solid, Liquid, and Vapor, Ebner and Sons Publishers, Seattle, 2013. |
|
[47] | Whitfield, J.R., and Soucek, L. “Tumor microenvironment: becoming sick of Myc”, Cell. Mol. Life Sci, 69 (6):931–934. May. 2012. |
|
[48] | Delbridge, A.R.D., Valente, L.J., and Strasser, A. “The Role of the Apoptotic Machinery in Tumor Suppression”, Cold Spring Harb Perspect Biol, 4(11):a008789. Nov. 2012. |
|
[49] | Saddic, L.A., Wirt, S., Vogel, H., Felsher, D.W., and Sage, J. “Functional Interactions between Retinoblastoma and c-MYC in a Mouse Model of Hepatocellular Carcinoma”, PLoS ONE, 6(5): e19758. May. 2011. |
|
[50] | Mowla, S.N., Perkins,N.D., and Jat,P.S. “Friend or foe: emerging role of nuclear factor kappa-light-chain-enhancer of activated B cells in cell senescence”, OncoTargets and Therapy, 6: 1221-1229. Sep. 2013. |
|
[51] | Hamblin, M.R. and Demidova, T.N. “Mechanisms of Low Level Light Therapy”, Proc. of SPIE, 6140: 614001-614012. Feb. 2006. |
|
[52] | Ross, S.J., and Critchlow, S.E. “Emerging approaches to target tumor metabolism”, Curr Opin Pharmacol, 17C: 22-29. Aug. 2014. |
|
[53] | Walz, S., Lorenzin, F., Morton, J., Wiese, K.E., von Eyss, B., Herold, S., Rycak, L., Dumay-Odelot, H., Karim, S., Bartkuhn, M., Roels, F., Wüstefeld, T., Fischer, M.,Teichmann, M., Zender, L., Wei, C.L., Sansom, O., Wolf, E., and Eilers, M. “Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles”, Nature, 511(7510):483-487. Jul. 2014. |
|
[54] | Bakker, H.J. “Water´s response to the fear of water”, Nature, 491 (7425): 533-535. Nov. 2012. |
|
[55] | Davis, J.G., Gierszal, K.P., Wang, P., and Ben-Amotz, D. “Water structural transformation at molecular hydrophobic interfaces”, Nature, 491(7425): 582-585. Nov. 2012. |
|
[56] | Springer, A., Hagenb, V., Cherepanovc, D.A., Antonenkod, Y.N., and Pohla, P. “Protons migrate along interfacial water without significant contributions from jumps between ionizable groups on the membrane surface”, PNAS. 108 (35):14461-14466. Aug. 2011. |
|
[57] | Sengupta, S., Spiering, M.M., Dey, K.K., Duan, W., Patra, D., Butler, P.J., Astumian, R.D., Benkovic, S.J., and Sen, A. “DNA polymerase as a molecular motor and pump”, ACS Nano, 8(3):2410-8. Mar. 2014. |
|
[58] | Radman, M. “Fidelity and infidelity”, Nature, 413 (6852): 115. Sep. 2001. |
|
[59] | Krisko, A., Radman, M. “Phenotypic and genetic consequences of protein damage”, PLoS Genet, 9(9): e1003810. Sep. 2013. |
|
[60] | Astumian, R.D. “Thermodynamics and kinetics of a Brownian motor”, Science, 276(5314): 917-922. May. 1997. |
|
[61] | Astumian, R.D. “Making molecules into motors”, Sci Am, 285(1):56-64. Jul. 2001. |
|
[62] | Santana-Blank, L., Rodríguez-Santana, E., Reyes, H., Santana-Rodríguez, J.A., and Santana-Rodríguez, K.E. “Laser photobiomodulation: A new promising player for the multi-halmark treatment of advanced cancer”, Int J Cancer Ther Oncol, 1(1): 6-8. Sep. 2013. |
|
[63] | Hanahan, D., and Weinberg, R.A. “Hallmarks of Cancer: The Next Generation”, Cell, 144(5): 646-674. Mar. 2011. |
|