Luis Santana-Blank^1,, Elizabeth Rodríguez-Santana¹, Karin E. Santana-Rodríguez¹, Jesús A. Santana-Rodríguez¹, Heberto Reyes^{1, 2}

The roles of water and carbon dioxide in laser/light interactions in higher-order biological systems and their implications in cellular microenvironments and complex systemic processes for the restoration of homeostasis-homeokinesis, even when metabolic pathways have been compromised, are discussed. This lecture summarizes three decades of pre-clinical and clinical investigations and the basis for a potentially new therapeutic approach for the treatment of advanced cancer and other complex diseases using laser photobiomodulation. We propose that light-water interactions offer a potent, alternate and complementary pathway to activate and modulate tumor suppression and/or proto-oncogenic expression through energy transfer via water and CO₂ in multi-fractal regimes, leading to the coupling of spatiotemporal oscillators. Laser photobiomodulation may, thus, offer the possibility of targeting multiple hallmarks of cancer and other complex diseases using fit-for-purpose electromagnetic (light) energy to restore physiologically reparative and regenerative mechanisms that can help reestablish homeostasis-homeokinesis, constituting a new emerging paradigm in the treatment of cancer and other complex diseases.

photobiomodulation, water, exclusion zone (EZ), biobattery, cancer, complex diseases