Evaluation of Cortisol, Malondialdehyde, Blood Glucose and Lipid Status on Haemoglobin Variants in Malaria Infected and Non- Malaria Infected Individuals

Esan. A.J^1,

¹Federal teaching hospital p.m.b 201 ido ekiti, nigeria

Cite this paper:
Esan. A.J. Evaluation of Cortisol, Malondialdehyde, Blood Glucose and Lipid Status on Haemoglobin Variants in Malaria Infected and Non- Malaria Infected Individuals. International Journal of Hematological Disorders. 2015; 2(1):18-23. doi: 10.12691/ijhd-2-1-4

Abstract

The aim of this study was to determine the effect of haemoglobin variants on pre, post anti-malaria drug treatment in malaria infected and non-infected individuals. The study was conducted at Federal Medical Centre, Ido-Ekiti, Nigeria. Two hundred and two blood samples were collected twice from each malaria infected individuals; grouped as pre-treatment and post anti-malaria drug treatment. One hundred and two blood samples from apparently healthy individuals were collected as control. Thick blood film was made and stained with Giemsa’s staining technique for malaria parasite detection; haemoglobin electrophoresis was determined using cellulose acetate electrophoresis at alkaline pH. Cortisol was estimated using enzyme linked immunosorbent assay method. Data obtained was analyzed using SPSS version 16. The mean±SD of cortisol and MDA of HbAA in pre treatment and post treatment was significantly (p<0.05) higher compared to HbAS and HbAC. This present study showed that, malaria parasite is more intense in HbAA compared to HbAS and HbAC, however use of effective anti-malaria therapy reduced the burden of malaria intensity.

Keywords:
malaria parasite stress and haemoglobin genotype

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