Effect of G₆PD Status in Malaria Infected Individuals on Haematological Parameters

Esan A.J^1,

¹Department of Haematology and Blood Transfusion Science, Federal Teaching Hospital, Ido-Ekiti, Nigeria

Cite this paper:
Esan A.J. Effect of G₆PD Status in Malaria Infected Individuals on Haematological Parameters. International Journal of Hematological Disorders. 2014; 1(1):55-57. doi: 10.12691/ijhd-1-1-11

Abstract

The aim of this study was to determine the effect of G₆PD status no haematological parameters in Plasmodium falciparum malaria infected and non-malaria infected individuals. The study was conducted at Federal Teaching Hospital, Ido-Ekiti, Nigeria. Malaria infected adult individuals; presented with signs and symptoms of malaria infection was used for the study. Two hundred and two blood samples were collected twice from the same malaria infected individuals; grouped as pre-treatment and post anti-malaria drug treatment. One hundred and two blood samples from apparently healthy individuals were collected for control; 5 ml of blood sample was collected and dispensed into di-potassium ethylenediaminetetracetic acid (K₂EDTA) vaccutainer bottles for haemoglobin concentration, packed cell volume and red cell indices were analysed using haematology analyser, thick blood film was made and stained with Giemsa’s staining technique for malaria parasite detection, the procedure was described by Monica Cheesbrough. Glucose-6-Phosphate dehydrogenase (G-6-PD) was performed using methaemoglobin reduction method within 6 hours of sample collection. The procedure was as described by Dacie and Lewis. Data obtained was analysed using SPSS version 16. The result of this present study showed that, the mean±SD of Hb, PCV, MCV and MCH were significantly (P<0.05) lower in G₆PD normal compared to G₆PD deficient in pre and post anti-malaria drug treatment while mean±SD of RBC, Hb and PCV were significantly (P<0.05) higher in G₆PD normal compared to G₆PD deficient in control subjects. This present study showed that malaria attack in G₆PD normal was observed more intensive compared to G₆PD deficient.

Keywords:
malaria parasite G₆PD status and haematological parameters

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