Severity and Prevalence of Malaria Infection and Effect of Anti-Malaria Drugs on Gender Differences Using Some Haematological Parameters

Esan Ayodele. J^1,

¹Department of Haematology and Blood Transfusion Science, Federal Medical Centre, P.M.B. 201, Ido-Ekiti Ekiti State

Cite this paper:
Esan Ayodele. J. Severity and Prevalence of Malaria Infection and Effect of Anti-Malaria Drugs on Gender Differences Using Some Haematological Parameters. International Journal of Hematological Disorders. 2014; 1(1):1-7. doi: 10.12691/ijhd-1-1-1

Abstract

Malaria is a major cause of morbidity and mortality in developing countries, accounting for an estimated of 300 to 500 million morbid episodes and 2 to 3 million death per year worldwide. The aim of the study is to determine severity and prevalence of malaria infection and effect of anti-malaria drugs on gender differences using haematological parameters. 202 confirmed malaria infected patients were recruited for the study between the ages of 15 – 64 years of both sexes at the general outpatient clinic of the Federal Medical Centre, Ido-Ekiti, Ekiti State, Nigeria. 4 ml of blood sample was collected twice from the same patient before and after taking anti-malaria drug into di-potassium ethylenediaminetetraacetic acid (K2EDTA) vacuitaner bottles for haematological analysis using haematology analyzer. Malaria parasite detection, malaria parasite count and malaria parasite species identification were also carried out. Out of the 202 malaria infected patients 129 (63.9%) were males and 73 (36.1%) were females. Mean+ SD of RBC, HB, PCV, MCV and MCHC in male were lower compared to female in pre and post anti malaria drug treatment; however, in control subjects mean+ SD of RBC, HB, PCV, MCV and MCHC in male were higher compared to female, the comparism shows significant difference (P<0.05). Severity and prevalence of malaria infection is more observed in male compared to female these might be as a result of different exposure to malaria vector.

Keywords:
malaria parasite gender anti-malaria drug

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References:

[1]	World Health Organization (WHO, 2000) Expert Committee on Malaria Twentieth report Geneva, world health organization, (WHO Technical report serie, No 892); 120 pp. 2000.
[2]	Breman JG, Egan A, Kensch GT. The intolerable burden of malaria: a new look at the numbers. AM J Trop Med Hyg; 64 1-2. (2001)
[3]	Miller LH, Baruch D I, Marsh K, Doumbo OK. The pathogenic basis of malaria. Nature; 415: 673-767. (2002).
[4]	Greenwood B. Malaria mortality and morbidity in Africa. Bulletin of the World Health Organization, 77 (8): 617-618. (1999).
[5]	Haynes RK. Artemisinin and derivatives: The future for malaria treatment? Curr Opin Infect Dis 14: 719-726. (2001).
[6]	World Health Organization (WHO, 2006). Guidelines for the Treatment of Malaria. Geneva: World Health Organization. (2006)
[7]	White NJ. "Anti-malaria drug resistance". J. Clin. Invest. 113 (8): 1084-1092. (2004).
[8]	Krishna. S. "Artemisinins: mechanisms of action and potential for resistance". Drug Resistance Updates 7: 233-244. (2004).
[9]	Rahman S. Gender aspects and women’s participation in the control and management of malaria in central Sudan. Social Science and Medicine, 42 (10). (1995).
[10]	Reuben R. Women and Malaria. Special Risks and Appropriate Control Strategy. Social Science and Medicine, 37 (4): 473-480. (1993).
[11]	Vlassoff C, Manderson L. Incorporating gender in the anthropology of infectious disease. Tropical Medicine and International Health, 3 (12): 1011-1019. (1998).
[12]	Tin-Oo P. Gender, mosquitoes and malaria: implication for Community development programmes in Lauptta, Myanmar. Southeast Asian Journal of Tropical Medicine and Public Health, 32 (3): 588-594. (2001).
[13]	Abdalla S.H and Pasvol .G. Malaria: A Hematolgical Perspective, Impeerial College Press, London, Uk. (2004).
[14]	Akhtar. S, Gumashta .R, Mahore. S and Maimoon. S. A hematolgical changes in malaria a comparative study, journal of pharmacy and Biological Sciences, vol. 2, no 4, pp. 15-19. (2012).
[15]	Dubey ML, Weingken C, Ganguly NK, Mahajan RC. Comparative evaluation of methods of malaria parasite density determination in blood samples from patients and experimental animals. Indian J Med Res; 109: 20-27. (1999)/
[16]	Maina R.N, Walsh .D, Gaddy. C Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya, Malaria Journal, vol. 9, no. 3. (2010).
[17]	Ovuakporaye S.I. Effect of malaria parasite on some haematological parameters: red blood cell count, packed cell volume and haemoglobin concentration. Journal of Medical and Applied Biosciences; 3: 45-51. (2011).
[18]	Jain. M, Gupta. S, Jain. J, and Grover. R. K. Usefulness of automated cell Counter in detection of malaria in a cancer set up-Our experience, Indian Journal of Pathology and Microbiology, vol. 55, no. 4, pp. 467-473. (2012).
[19]	George I.O and Ewelike-Ezeeni C.S. Haematological changes in children With malaria infection in Nigreria, journal of Medicine and Medical Science Vol. 2, no. 4 pp. 768-771. (2011).
[20]	Monica Cheesbrough. Discrete Laboratory Practice in Tropical Countries Part 1, Cambridge Second Editions. Published by Press Syndicate of the University of Cambridge, chp. 5, page 247-258. (2005).
[21]	Dayachi F, Kabongo L, Ngoie K. Decreased mortality from Malaria in children with symptomatic HIV infection. Int. Cont. AIDS 2: 164. (1991).
[22]	Warhurst, D.C. and J.E. Williams. Acp Broadsheet no 148. July 1996. Laboratory diagnosis of malaria. J. Clin. Pathol., 49: 533-538. (1996).
[23]	Chandra. S and Chandra. H. Role of haematological parameters as an indicator of acute malarial infection Diseases, Vol. 5, no. 1. (2013).
[24]	Akanbi, O.M., J.A. Badaki, O.Y. Adeniran and O.O. Olotu,. Effect of blood group and demographic characteristics on malaria infection, oxidative stress and haemoglobin levels in South Western Nigeria. Afr. J. Microbiol. Res., 4: 877-880. (2010).
[25]	Zuk M, McKean KA. Sex differences in parasite infections: patterns and processes. Inter J Parasitol; 26: 1009-1023. (1996).
[26]	Cernetich A, Garver L S, Jedlicka. Involvement of gonadial steroids and gamma interferon in sex differences in responses to blood stage malaria infection. Infect Immum; 63: 222-230. (2006).
[27]	Krucken J, Dkhil M A, Braun J V. Testosterone suppresses protective responses of the liver to blood stage malaria. Infect imumm; 73: 436-443. (2005).
[28]	Rashed S. Determinants of the Permethrin impregnated Bednets (PHB) In the Republic of Benin: the social of women in the acquisition and utilization of PIBs. Social Science and Medicine, 49: 993-1005. (1999).
[29]	Muller I. The effect of distance from home on attendance at a small rural health centre in Papua New Guinea. International Journal of Epidemiology, 27: 878-884. (1998).
[30]	Angus BJ, Chotivanich K, Silamut K, Ruangveerayuth R, Hardeman MR. Red blood cell deformability as a predictor of anemia in severe Falciparum malaria. Am J Trop Med Hyg; 60: 733-737. 1999.
[31]	Kochar DK, Das A, Kochar SK, Saxena V, Sirohi P, Garg S. Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in north western India. Am J Trop Med Hyg, 80 (2): 194-198. 2009
[32]	Sowunmi A, Balogun ST, Gbotosho GO, Happi CT. Effects of amodiaquine, artesunate, and artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children. Acta Trop., 109: 55-60. (2009).