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International Journal of Dental Sciences and Research
ISSN (Print): 2333-1135 ISSN (Online): 2333-1259 Website: https://www.sciepub.com/journal/ijdsr Editor-in-chief: Marcos Roberto Tovani Palone
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International Journal of Dental Sciences and Research. 2018, 6(1), 6-11
DOI: 10.12691/ijdsr-6-1-2
Open AccessArticle

Could Int-8 Receptors and VEGF be Considered as Potential Prognostic Markers in OSCC?

Omneya R. Ramadan1, , Maged H. El-Abany1 and Wafaa A. Awedat1

1Oral Pathology, Faculty of Dentistry, Alexandria University

Pub. Date: January 29, 2018
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Cite this paper:
Omneya R. Ramadan, Maged H. El-Abany and Wafaa A. Awedat. Could Int-8 Receptors and VEGF be Considered as Potential Prognostic Markers in OSCC?. International Journal of Dental Sciences and Research. 2018; 6(1):6-11. doi: 10.12691/ijdsr-6-1-2

Abstract

Objectives: The goal of this study was to determine the correlation of clinicopathological factors and the up-regulation of Int-8 receptors and vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma (OSCC). Materials and Methods: Clinical data (age, gender, size of the tumor, location of the tumor, lymph nodes status,..) were collected from 20 patients with OSCC, tabulated and statistically analyzed (SPSS17). Immunohistochemical stainings of Int-8 receptors, CXCR1 and CXCR2 (united states biological, United Bio, USA) and VEGF (Abcam, Cambridge, MA, USA) were done. Results: Our immunohistochemical study demonstrated: 1) expression of Int-8 receptors in all cases of OSCC with variable intensities, 2) high-level staining of VEGF In poorly differentiated and invasive oral squamous cell carcinoma. Significant correlation was observed between immunohistochemical expression of Int-8 receptors, VEGF and histologic differentiation and clinical stages (Analysis of variance ANOVA, P<0.05). Conclusion: Our findings suggest that the reactivity to Int-8 receptors observed in OSCC cases could be used as a parameter for tumor aggressiveness and as potential prognostic marker. Also, up-regulation of VEGF may play a role in the angiogenesis and progression of oral squamous cell carcinoma.

Keywords:
squamous cell carcinoma int-8 receptors vascular endothelial growth factor

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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