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Watanabe H, Iwase M, Ohashi M, Nagumo M. Role of interleukin-8 secreted from human oral squamous cell carcinoma cell lines. Oral Oncology 2002; 38: 670-679.

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Article

Could Int-8 Receptors and VEGF be Considered as Potential Prognostic Markers in OSCC?

1Oral Pathology, Faculty of Dentistry, Alexandria University


International Journal of Dental Sciences and Research. 2018, Vol. 6 No. 1, 6-11
DOI: 10.12691/ijdsr-6-1-2
Copyright © 2018 Science and Education Publishing

Cite this paper:
Omneya R. Ramadan, Maged H. El-Abany, Wafaa A. Awedat. Could Int-8 Receptors and VEGF be Considered as Potential Prognostic Markers in OSCC?. International Journal of Dental Sciences and Research. 2018; 6(1):6-11. doi: 10.12691/ijdsr-6-1-2.

Correspondence to: Omneya  R. Ramadan, Oral Pathology, Faculty of Dentistry, Alexandria University. Email: omneya2y@gmail.com

Abstract

Objectives: The goal of this study was to determine the correlation of clinicopathological factors and the up-regulation of Int-8 receptors and vascular endothelial growth factor (VEGF) expression in oral squamous cell carcinoma (OSCC). Materials and Methods: Clinical data (age, gender, size of the tumor, location of the tumor, lymph nodes status,..) were collected from 20 patients with OSCC, tabulated and statistically analyzed (SPSS17). Immunohistochemical stainings of Int-8 receptors, CXCR1 and CXCR2 (united states biological, United Bio, USA) and VEGF (Abcam, Cambridge, MA, USA) were done. Results: Our immunohistochemical study demonstrated: 1) expression of Int-8 receptors in all cases of OSCC with variable intensities, 2) high-level staining of VEGF In poorly differentiated and invasive oral squamous cell carcinoma. Significant correlation was observed between immunohistochemical expression of Int-8 receptors, VEGF and histologic differentiation and clinical stages (Analysis of variance ANOVA, P<0.05). Conclusion: Our findings suggest that the reactivity to Int-8 receptors observed in OSCC cases could be used as a parameter for tumor aggressiveness and as potential prognostic marker. Also, up-regulation of VEGF may play a role in the angiogenesis and progression of oral squamous cell carcinoma.

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