International Journal of Clinical and Experimental Neurology
ISSN (Print): 2379-7789 ISSN (Online): 2379-7797 Website: https://www.sciepub.com/journal/ijcen Editor-in-chief: Zhiyou Cai, MD
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International Journal of Clinical and Experimental Neurology. 2014, 2(2), 29-39
DOI: 10.12691/ijcen-2-2-3
Open AccessReview Article

The Prevalence, Incidence and Etiology of Epilepsy

Shakirullah1, , Niaz Ali1, Aslam khan1 and Muhammad Nabi1

1Basic Medical Science, Khyber Medical University Peshawar Phase IV, Hayatabad, Peshawar, Pakistan

Pub. Date: December 28, 2014

Cite this paper:
Shakirullah, Niaz Ali, Aslam khan and Muhammad Nabi. The Prevalence, Incidence and Etiology of Epilepsy. International Journal of Clinical and Experimental Neurology. 2014; 2(2):29-39. doi: 10.12691/ijcen-2-2-3

Abstract

Epilepsy is a neuronal disorder that is observed globally but still it is not explored very well in most parts of the world. This disease is linked to different provocative causes and affects almost all generation, ethnicity and age population. Therefore, the aim of this article is to systemically review the literature about the prevalence, incidence and etiology of epilepsy to find possible approaches to control epilepsy. The worldwide prevalence of epilepsy is variable and varied among countries. High prevalence is found in adolescent and early age group population. In North America, Central and South America high prevalence is found in male except in New York, Bolivia, Honduras and Argentina where prevalence is high in female. In Asian countries such as China, India, Turkey and Saudi Arabia the prevalence is high in Male except in Pakistan here prevalence is high in female similarly to European countries where also prevalence is high in female. The prevalence of epilepsy in male and female is variable in African countries. Generalized seizure is high in America, Asia, Europe, and Africa than the other types of epilepsies. Very limited data is available about the incidence of epilepsy especially from low and lower middle income countries. The incidence rate of epilepsy is higher in the developing countries than the industrialized countries. Similarly, the incidence is also higher in male than female. Head injury, birth trauma, cerebrovascular disease, and intracranial infections (neurocysticercosis or meningoencephalitis) and genetic factors are the main causes of epilepsy.

Keywords:
prevalence incidence epilepsy and causes of epilepsy

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References:

[1]  Eucare., European white paper on epilepsy-call to action. Epilepsia, 2003. 44(6): p. 4-8.
 
[2]  Leon Shargel, et al., Comprehensive pharmacy Review for NAPLEX 8th Edition. Wolters Kluwer/ Lippincott Williams & Wilikin, 2000: p. pp743.
 
[3]  Saraceno., B., EPILEPSY IN THE WHO EUROPEAN REGION. 2005.
 
[4]  R., K., Bringing epilepsy out of the shadows. BMJ, 1997. 315: p. 2-3.
 
[5]  Giuliano Avanzini and L. Prilipko., Epilepsy Care in the World WHO 2005. Epilepsy Atlas, 2005.
 
[6]  Ngugi AK, et al., Estimation of the burden of active and life‐time epilepsy: A meta‐analytic approach. Epilepsia., 2010. 51(5): p. 883-890.
 
[7]  Organization., W.H., Epilepsy: aetiology, epidemiology and prognosis. WHO Fact Sheet., 2009. No. 999.
 
[8]  Khatri I, et al., Epidemiology of epilepsy in Pakistan: review of literature. Epidemiology., 2003.
 
[9]  Khan N, et al., Audit of 100 cases of epilepsy in a tertiary care hospital. Gomal Journal of Medical Sciences., 2010. 9(1).
 
[10]  Malik MA, et al., Childhood epilepsy. Journal of College Physicians Surgeon Pakistan., 2011. 21(2): p. 74-8.
 
[11]  Mac TL, et al., Epidemiology, aetiology, and clinical management of epilepsy in Asia: a systematic review. The Lancet Neurology., 2007. 6(6): p. 533-43.
 
[12]  Aziz H, Akhtar SW, and H. KZ., Epilepsy in Pakistan: Stigma and Psychosocial Problems. A Population‐Based Epidemiologic Study. Epilepsia., 1997. 38(10): p. 1069-73.
 
[13]  Aziz H, et al., Comparative Epidemiology of Epilepsy in Pakistan and Turkey: Population‐Based Studies Using Identical Protocols. Epilepsia., 1997. 38(6): p. 716-22.
 
[14]  Sridharan, R. and B. Murthy, Prevalence and pattern of epilepsy in India. Epilepsia, 1999. 40(5): p. 631-636.
 
[15]  Radhakrishnan, K., et al., Prevalence, knowledge, attitude, and practice of epilepsy in Kerala, South India. Epilepsia, 2000. 41(8): p. 1027-1035.
 
[16]  Khadilkar, S., Neurology: the scenario in India. J Assoc Physicians India, 2012. 60: p. 42-4.
 
[17]  Das, K., et al., Evaluation of socio-economic factors causing discontinuation of epilepsy treatment resulting in seizure recurrence: a study in an urban epilepsy clinic in India. Seizure, 2007. 16(7): p. 601-607.
 
[18]  Leonardi, M. and T.B. Ustun, The global burden of epilepsy. Epilepsia, 2002. 43(s6): p. 21-25.
 
[19]  Mani, K., et al., The Yelandur study: a community-based approach to epilepsy in rural South India—epidemiological aspects. Seizure, 1998. 7(4): p. 281-288.
 
[20]  PS, R., et al., Quality of life among people with epilepsy: A cross-sectional study from rural southern India. Natl Med J India, 2012. 25: p. 261-4.
 
[21]  Huang, M., et al., [The prevalence of epilepsy in rural Jinshan in Shanghai]. Zhonghua liu xing bing xue za zhi= Zhonghua liuxingbingxue zazhi, 2002. 23(5): p. 345-346.
 
[22]  Gu, L., et al., Prevalence of epilepsy in the People's Republic of China: A systematic review. Epilepsy research, 2013. 105(1): p. 195-205.
 
[23]  Wang, W., et al., [Epidemiological survey on epilepsy among rural populations in five provinces in China]. Zhonghua yi xue za zhi, 2002. 82(7): p. 449-452.
 
[24]  de Boer, H.M., et al., ILAE/IBE/WHO Global Campaign Against Epilepsy: a partnership that works. Current opinion in neurology, 2013. 26(2): p. 219-225.
 
[25]  Mannan, M., Epilepsy in Bangladesh. Neurol Asia, 2004. 9(1): p. 18.
 
[26]  abu nasar rizvi, et al., Epileptic Patients Attending in a Tertiary Care Hospital:A 4 (four) Years Study. Bangladesh Journal of Neuroscience 2011. 27(1): p. 18-21.
 
[27]  Ebrahimi, H., M. Shafa, and S. Hakimzadeh Asl, Prevalence of active epilepsy in Kerman, Iran: a house based survey. Acta Neurol Taiwan, 2012. 21(3): p. 115-24.
 
[28]  Inaloo, S. and P. Katibeh, An epidemiologic study of 389 children with epilepsy in southern Iran. IJCN, 2011. 5(4): p. 15-20.
 
[29]  Khedr, E.M., et al., A community based epidemiological study of epilepsy in Assiut Governorate/Egypt. Epilepsy research, 2013. 103(2): p. 294-302.
 
[30]  Benamer, H.T. and D.G. Grosset, A systematic review of the epidemiology of epilepsy in Arab countries. Epilepsia, 2009. 50(10): p. 2301-2304.
 
[31]  Theodore, W.H., et al., Epilepsy in North America: a report prepared under the auspices of the global campaign against epilepsy, the International Bureau for Epilepsy, the International League Against Epilepsy, and the World Health Organization. Epilepsia, 2006. 47(10): p. 1700-1722.
 
[32]  Kelvin, E.A., et al., Prevalence of self-reported epilepsy in a multiracial and multiethnic community in New York City. Epilepsy research, 2007. 77(2): p. 141-150.
 
[33]  Haerer, A.F., D.W. Anderson, and B.S. Schoenberg, Prevalence and clinical features of epilepsy in a biracial United States population. Epilepsia, 1986. 27(1): p. 66-75.
 
[34]  Melcon, M.O., S. Kochen, and R.H. Vergara, Prevalence and clinical features of epilepsy in Argentina. Neuroepidemiology, 2006. 28(1): p. 8-15.
 
[35]  Cruz, M.E., et al., Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. Neuroepidemiology, 1985. 4(2): p. 108-116.
 
[36]  Russ, S.A., K. Larson, and N. Halfon, A national profile of childhood epilepsy and seizure disorder. Pediatrics, 2012. 129(2): p. 256-264.
 
[37]  Frieden, T.R., Epilepsy in adults and access to care--United States, 2010. Center for disease control and prevention MMWR. Morbidity and mortality weekly report, 2012. 61(45): p. 909.
 
[38]  Tellez-Zenteno, J.F., et al., National and Regional Prevalence of Self‐reported Epilepsy in Canada. Epilepsia, 2004. 45(12): p. 1623-1629.
 
[39]  Tekle-Haimanot, R., et al., Clinical and electroencephalographic characteristics of epilepsy in rural Ethiopia: a community-based study. Epilepsy research, 1990. 7(3): p. 230-239.
 
[40]  Purcell, B., et al., Epilepsy prevalence and prescribing patterns in England and Wales. Health Statistics Quarterly, 2002. 15(Autumn): p. 23-30.
 
[41]  Forsgren, L., et al., The epidemiology of epilepsy in Europe–a systematic review. European Journal of Neurology, 2005. 12(4): p. 245-253.
 
[42]  Berg, A.T., et al., Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005–2009. Epilepsia, 2010. 51(4): p. 676-685.
 
[43]  43.Blume, W.T., et al., Glossary of descriptive terminology for ictal semiology: report of the ILAE task force on classification and terminology. Epilepsia, 2001. 42(9): p. 1212-1218.
 
[44]  Brown, S., et al., Epilepsy needs revisited: a revised epilepsy needs document for the UK. Seizure, 1998. 7(6): p. 435-446.
 
[45]  Shorvon, S.D., Handbook of epilepsy treatment. 2005: John Wiley & Sons.
 
[46]  Sander, J.W., The use of antiepileptic drugs—principles and practice. Epilepsia, 2004. 45(s6): p. 28-34.
 
[47]  WHO, Fact sheet 999, epilepsy.
 
[48]  Forsgren, L., et al., Incidence and Clinical Characterization of Unprovoked Seizures in Adults: A Prospective Population‐Based Study. Epilepsia, 1996. 37(3): p. 224-229.
 
[49]  Linehan, C., The Prevalence of Epilepsy in Ireland: Brainwave The Irish Epilepsy Association Summary Report 2009. 2012.
 
[50]  Gekht, A., et al., An epidemiological study of epilepsy in Moscow. Zhurnal nevrologii i psikhiatrii imeni SS Korsakova/Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov, 1999. 99(10): p. 51.
 
[51]  MacDonald, B., et al., The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain, 2000. 123(4): p. 665-676.
 
[52]  M. Belhocine, H.M. de Boer, and C. Mandlhate., The global campaign against epilepsy: out of the shadows. WHO, 2004.
 
[53]  Diagana, M., et al., Dépistage de l’épilepsie en zones tropicales: validation d’un questionnaire en Mauritanie. Bull Soc Pathol Exot, 2000. 93: p. 276-8.
 
[54]  M., D.-C., Epilepsie en Afrique subsaharienne. Thèse, Universitéde Limoges, France, 2002.
 
[55]  Rwiza, H., et al., Prevalence and Incidence of Epilepsy in Ulanga, a Rural Tanzanian District: A Community‐Based Study. Epilepsia, 1992. 33(6): p. 1051-1056.
 
[56]  Hackett, M.L., et al., Sydney epilepsy incidence study to measure illness consequences: the SESIMIC observational epilepsy study protocol. BMC neurology, 2011. 11(1): p. 3.
 
[57]  D’Souza, W.J., et al., The Tasmanian Epilepsy Register–a community-based cohort. Neuroepidemiology, 2008. 29(3-4): p. 255-263.
 
[58]  Noronha, A.L., et al., Prevalence and pattern of epilepsy treatment in different socioeconomic classes in Brazil. Epilepsia, 2007. 48(5): p. 880-885.
 
[59]  Reggio, A., et al., Prevalence of epilepsy. A door-to-door survey in the Sicilian community of Riposto. The Italian Journal of Neurological Sciences, 1996. 17(2): p. 147-151.
 
[60]  Rocca, W., et al., Door-to-door prevalence survey of epilepsy in three Sicilian municipalities. Neuroepidemiology, 2001. 20(4): p. 237-241.
 
[61]  Onal, A.E., et al., Epilepsy prevalence in a rural area in Istanbul. Seizure, 2002. 11(6): p. 397-401.
 
[62]  Karaaĝaç, N., et al., Prevalence of epilepsy in Silivri, a rural area of Turkey. Epilepsia, 1999. 40(5): p. 637-642.
 
[63]  Chong-Tin, T., Differences in epilepsy and seizures between Asia and the West. Neurology Asia, 2007. 12: p. 59-60.
 
[64]  Jallon, P., Epilepsy in developing countries. Epilepsia, 1997. 38(10): p. 1143-1151.
 
[65]  Õun, A., S. Haldre, and M. Mägi, Prevalence of adult epilepsy in Estonia. Epilepsy research, 2003. 52(3): p. 233-242.
 
[66]  Lavados, J., et al., A descriptive study of epilepsy in the district of El Salvador, Chile, 1984–1988. Acta neurologica scandinavica, 1992. 85(4): p. 249-256.
 
[67]  Basch, E., et al., Prevalence of epilepsy in a migrant population near Quito, Ecuador. Neuroepidemiology, 1997. 16(2): p. 94-98.
 
[68]  Olafsson, E. and W.A. Hauser, Prevalence of Epilepsy in Rural Iceland: A Population‐Based Study. Epilepsia, 1999. 40(11): p. 1529-1534.
 
[69]  Birbeck, G.L. and E. Kalichi, Epilepsy prevalence in rural Zambia: a door-to-door survey. Tropical Medicine & International Health, 2004. 9(1): p. 92-95.
 
[70]  Forsgren, L., Prevalence of epilepsy in adults in northern Sweden. Epilepsia, 1992. 33(3): p. 450-458.
 
[71]  Placencia, M., et al., Epileptic seizures in an Andean region of Ecuador: incidence and prevalence and regional variation. Brain, 1992. 115(3): p. 771-782.
 
[72]  Nicoletti, A., et al., Prevalence of epilepsy in rural Bolivia A door-to-door survey. Neurology, 1999. 53(9): p. 2064-2064.
 
[73]  Medina, M.T., et al., Prevalence, incidence, and etiology of epilepsies in rural Honduras: the Salama Study. Epilepsia, 2005. 46(1): p. 124-131.
 
[74]  Li, S.c., et al., Epidemiology of epilepsy in urban areas of the People's Republic of China. Epilepsia, 1985. 26(5): p. 391-394.
 
[75]  Koul, R., S. Razdan, and A. Motta, Prevalence and pattern of epilepsy (Lath/Mirgi/Laran) in rural Kashmir, India. Epilepsia, 1988. 29(2): p. 116-122.
 
[76]  Al Rajeh, S., et al., The prevalence of epilepsy and other seizure disorders in an Arab population: a community-based study. Seizure, 2001. 10(6): p. 410-414.
 
[77]  Osuntokun, B.O., et al., Research protocol for measuring the prevalence of neurologic disorders in developing countries. Neuroepidemiology, 1982. 1(3): p. 143-153.
 
[78]  Osuntokun, B., et al., Prevalence of the Epilepsies in Nigerian Africans: A Community‐Based Study. Epilepsia, 1987. 28(3): p. 272-279.
 
[79]  Longe, A. and B. Osuntokun, Prevalence of neurological disorders in Udo, a rural community in southern Nigeria. Tropical and geographical medicine, 1989. 41(1): p. 36-40.
 
[80]  Kaiser, C., et al., Rating D, Leichsenring M, 1996. The prevalence of epilepsy follows the distribution of onchocerciasis in a west Ugandan focus. Bull World Health Organ. 74: p. 361-367.
 
[81]  Attia-Romdhane, N., A. Mrabet, and M.B. Hamida, Prevalence of epilepsy in Kelibia, Tunisia. Epilepsia, 1993. 34(6): p. 1028-1032.
 
[82]  Snow, R., et al., The prevalence of epilepsy among a rural Kenyan population. Its association with premature mortality. Tropical and geographical medicine, 1993. 46(3): p. 175-179.
 
[83]  Dent, W., et al., Prevalence of Active Epilepsy in a Rural Area in South Tanzania: A Door‐to‐Door Survey. Epilepsia, 2005. 46(12): p. 1963-1969.
 
[84]  Bharucha, N.E., et al., Prevalence of epilepsy in the Parsi community of Bombay. Epilepsia, 1988. 29(2): p. 111-115.
 
[85]  Wright, J., et al., A population-based study of the prevalence, clinical characteristics and effect of ethnicity in epilepsy. Seizure, 2000. 9(5): p. 309-313.
 
[86]  Banerjee, P.N., D. Filippi, and W. Allen Hauser, The descriptive epidemiology of epilepsy—a review. Epilepsy research, 2009. 85(1): p. 31-45.
 
[87]  Kotsopoulos, I.A., et al., Systematic Review and Meta‐analysis of Incidence Studies of Epilepsy and Unprovoked Seizures. Epilepsia, 2002. 43(11): p. 1402-1409.
 
[88]  Benn, E.K., et al., Estimating the incidence of first unprovoked seizure and newly diagnosed epilepsy in the low‐income urban community of Northern Manhattan, New York City. Epilepsia, 2008. 49(8): p. 1431-1439.
 
[89]  Hauser, W.A., J.F. Annegers, and L.T. Kurland, Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia, 1993. 34(3): p. 453-458.
 
[90]  Graaf, A.d., Epidemiological aspects of epilepsy in northern Norway. Epilepsia, 1974. 15(3): p. 291-299.
 
[91]  Stephen, L.J. and M.J. Brodie, Epilepsy in elderly people. The Lancet, 2000. 355(9213): p. 1441-1446.
 
[92]  Granieri, E., et al., A descriptive study of epilepsy in the district of Copparo, Italy, 1964–1978. Epilepsia, 1983. 24(4): p. 502-514.
 
[93]  Olafsson, E., et al., Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study. The Lancet Neurology, 2005. 4(10): p. 627-634.
 
[94]  Klein, P., L.M. van Passel-Clark, and J.C. Pezzullo, Onset of epilepsy at the time of menarche. Neurology, 2003. 60(3): p. 495-497.
 
[95]  Kaneko, S., et al., Genetics of epilepsy: current status and perspectives. Neuroscience research, 2002. 44(1): p. 11-30.
 
[96]  Epilepsy, C.o.T.D.o.t.I.L.A., Relationship between epilepsy and tropical diseases. Epilepsia, 1994. 35: p. 89–93.
 
[97]  Garcia, H.H. and O.H. Del Brutto, Neurocysticercosis: updated concepts about an old disease. The Lancet Neurology, 2005. 4(10): p. 653-661.
 
[98]  Murthy, J., et al., Acute symptomatic seizures associated with neurocysticercosis: A community-based prevalence study and comprehensive rural epilepsy study in South India. Neurol Asia, 2004. 9(Suppl 1): p. 86.
 
[99]  Tran, D.-S., et al., Prevalence of epilepsy in a rural district of central Lao PDR. Neuroepidemiology, 2006. 26(4): p. 199-206.
 
[100]  Kuruvilla, A., et al., Neurocysticercosis: a clinical and radiological appraisal from Kerala State, South India. Singapore medical journal, 2001. 42(7): p. 297-303.
 
[101]  Jain, S., et al., Twin birth and epilepsy: an expanded India study. Neurol J Southeast Asia, 1999. 4: p. 19-23.
 
[102]  Sharma, K., Genetic epidemiology of epilepsy: a twin study. Neurology India, 2005. 53(1): p. 93.
 
[103]  Lu, J., et al., The gene encoding GABBR1 is not associated with childhood absence epilepsy in the Chinese Han population. Neuroscience letters, 2003. 343(3): p. 151-154.
 
[104]  Ren, L., et al., Lack of GABABR1 gene variation (G1465A) in a Chinese population with temporal lobe epilepsy. Seizure, 2005. 14(8): p. 611-613.
 
[105]  Chen, Y., et al., [Association of child absence epilepsy with T-STAR gene]. Zhonghua yi xue za zhi, 2003. 83(13): p. 1134-1137.
 
[106]  Chen, Y., et al., T-type calcium channel gene alpha (1G) is not associated with childhood absence epilepsy in the Chinese Han population. Neuroscience letters, 2003. 341(1): p. 29-32.
 
[107]  Nair, R.R. and S.V. Thomas, Genetic liability to epilepsy in Kerala State, India. Epilepsy research, 2004. 62(2): p. 163-170.
 
[108]  Ramasundrum, V. and C.T. Tan, Consanguinity and risk of epilepsy. Neurol Asia, 2004. 9(Suppl 1): p. 10-11.