International Journal of Clinical and Experimental Neurology
ISSN (Print): 2379-7789 ISSN (Online): 2379-7797 Website: Editor-in-chief: Zhiyou Cai, MD
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International Journal of Clinical and Experimental Neurology. 2022, 9(1), 1-3
DOI: 10.12691/ijcen-9-1-1
Open AccessCase Report

Stiff Person Syndrome Overlapping with Multiple Sclerosis

Hassan AlHussein1, , Syed Ali Raza1 and Roger E. Kelley1

1Ochsner Louisiana State University Health Shreveport, LA

Pub. Date: May 15, 2022

Cite this paper:
Hassan AlHussein, Syed Ali Raza and Roger E. Kelley. Stiff Person Syndrome Overlapping with Multiple Sclerosis. International Journal of Clinical and Experimental Neurology. 2022; 9(1):1-3. doi: 10.12691/ijcen-9-1-1


We report the apparent rare association of longstanding relapsing/remitting multiple sclerosis and stiff person syndrome. This middle-aged woman presented with truncal and lower extremities stiffness and spasm not responsive to a course of intravenous methylprednisolone or to high dose muscle relaxants. Her discomfort had progressed, over a one-month period, to being wheelchair bound and considering herself desperate for some type of relief. Of interest, she pursued the medical literature, as a registered nurse, and became convinced that she has stiff person syndrome superimposed on her multiple sclerosis which has not been previously reported. She was found to have an elevated anti-glutamic acid decarboxylase (GAD)-65 antibody titer supporting this association. She was responsive, at least over the short term, to a course of intravenous gamma globulin along with the addition of dantrolene to her regimen.

multiple sclerosis stiff person syndrome anti-glutamic acid decarboxylase (GAD) antibodies progressive encephalomyelitis with rigidity and myoclonus (PERM)

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