Iron Deficiency with Anemia in Adult Celiac Disease: Complication or Presenting Clinical Feature

Hugh James Freeman^1,

¹Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada

Cite this paper:
Hugh James Freeman. Iron Deficiency with Anemia in Adult Celiac Disease: Complication or Presenting Clinical Feature. International Journal of Celiac Disease. 2022; 10(1):1-4. doi: 10.12691/ijcd-10-1-1

Abstract

Adults with celiac disease may be complicated by iron deficiency anemia, largely because the primary site of intestinal involvement in celiac disease, the duodenum, is also the most important site for intestinal absorption of iron. In some, iron deficiency anemia may be the sole presenting feature of celiac disease even in the absence of diarrhea or weight loss. Even in treated and long-standing celiac disease, persistence of iron deficiency anemia, or even its new appearance, may be important as clinical markers for an additional or superimposed cause including ulcerative or neoplastic disease, including lymphoma. Other rare causes include a hemolytic disorder, sometimes immune-mediated, anemia associated with a chronic inflammatory disease process, or a sideroblastic anemia, reported to also respond to a gluten-free diet.

Keywords:
adult celiac disease iron deficiency anemia iron refractory anemia gluten-free diet colorectal cancer

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