1Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada
International Journal of Celiac Disease.
2022,
Vol. 10 No. 1, 1-4
DOI: 10.12691/ijcd-10-1-1
Copyright © 2022 Science and Education PublishingCite this paper: Hugh James Freeman. Iron Deficiency with Anemia in Adult Celiac Disease: Complication or Presenting Clinical Feature.
International Journal of Celiac Disease. 2022; 10(1):1-4. doi: 10.12691/ijcd-10-1-1.
Correspondence to: Hugh James Freeman, Department of Medicine (Gastroenterology), University of British Columbia, Vancouver, British Columbia, Canada. Email:
hugfree@shaw.caAbstract
Adults with celiac disease may be complicated by iron deficiency anemia, largely because the primary site of intestinal involvement in celiac disease, the duodenum, is also the most important site for intestinal absorption of iron. In some, iron deficiency anemia may be the sole presenting feature of celiac disease even in the absence of diarrhea or weight loss. Even in treated and long-standing celiac disease, persistence of iron deficiency anemia, or even its new appearance, may be important as clinical markers for an additional or superimposed cause including ulcerative or neoplastic disease, including lymphoma. Other rare causes include a hemolytic disorder, sometimes immune-mediated, anemia associated with a chronic inflammatory disease process, or a sideroblastic anemia, reported to also respond to a gluten-free diet.
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