Preparation and Functional Analysis of a New Cosmetics Raw Materials with Sika Deer Skin Peptide and Angelica Dahurica

Yang Guan¹, Yao Sun^1, , Xiao-chen Gao², Tian Tian¹, Jia-yuan Yang¹ and Yi Xu¹

¹Changchun University of Technology, Changchun 130012, China

²Jilin Ginseng Academy and Changchun University of Chinese Medicine, Changchun 130117, Jilin, China

Cite this paper:
Yang Guan, Yao Sun, Xiao-chen Gao, Tian Tian, Jia-yuan Yang and Yi Xu. Preparation and Functional Analysis of a New Cosmetics Raw Materials with Sika Deer Skin Peptide and Angelica Dahurica. Biomedicine and Biotechnology. 2023; 8(1):1-13. doi: 10.12691/bb-8-1-1

Abstract

Based on the traditional medicine cosmetic formula, sika deer skin peptides (SDSP) and the effective ingredients extracted from Angelica dahurica were added for preparation of a new cosmetic raw material. In this study, the composite protease group was selected as the tool enzyme by single factor orthogonal test and response surface method for hydrolyzing the total protein of deer skin. The optimal enzymatic hydrolysis process of deer skin protein was as follows: temperature at 51°C, pH 7.0, 6000 U/g of enzyme addition and reaction time in 5h and SDSP was obtained. The molecular weight of SDSP was 851 Da to 11 092 Da by exclusion chromatography analysis. The analysis of amino acid composition showed that SDSP were rich in Gly, Ala, Pro, Hyp and terpeneine. Under the same extraction conditions, ethanol extract content from Angelica dahurica showed a highest level, 8 kinds of furocoumarines compounds were identified in it by HPLC-ESI-MS analysis. The results also demonstrated that mixture of Angelica dahurica extraction and SDSP with the rate of 2:1 indicated the best moisturizing effect. Free radical scavenging ability of facial base liquids reached 81% in 2.0 mg/mL. The inhibition rates of tyrosinase reached 61.12% at 8 mg/mL. This new cosmetics raw materials provided a basic process for producing cosmetic raw material with remarkable whitening effect and excellent moisturizing performance.

Keywords:
Cervus nippon commercial facial materials Angelica dahurica HPLC-ESI-MS

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References:

[1]	Ecology Research; Research Data from Northeast Forestry University Update Understanding of Ecology Research (Winter Diet Variation and Overlap of Sympatric Red Deer and Sika Deer In Northeast China) [J]. Energy & Ecology, 2020.
[2]	Beaver Fur and Deer Skin: Teaching Colonial American Literature in Taiwan's Context [J]. Linguistics and Literature Studies, 2018, 6(1)
[3]	Yan Jin et al. Screening and identification of DPP-IV inhibitory peptides from deer skin hydrolysates by an integrated approach of LC–MS/MS and in silico analysis [J]. Journal of Functional Foods, 2015, 18: 344-357.
[4]	Pan-On S, Rujivipat S, Ounaroon A, et al. Development and characterization of clay facial material containing turmeric extract solid dispersion. Drug Dev Ind Pharm. 2018; 44(4): 590-597.
[5]	Huang YW, Huang HH, Wu GX, et al. Antiaging and smoothness-improving properties of farnesol-based facial materials on rat skin exposed to ultraviolet B. J Cosmet Dermatol. 2020; 19(2): 540-552.
[6]	Min Wang et al. The application of a lateral flow immunographic assay to rapidly test for dexamethasone in commercial facial materials [J]. Analytical and Bioanalytical Chemistry, 2019, 411(22): 5703-5710.
[7]	I. B. S. Sitohang and S. Ninditya and E. Helen Kemp. Systemic Glutathione as a Skin-Whitening Agent in Adult[J]. Dermatology Research and Practice, 2020, 2020
[8]	Nilforoushzadeh MA, Amirkhani MA, Zarrintaj P, et al. Skin care and rejuvenation by cosmeceutical facial material. J Cosmet Dermatol. 2018; 17(5): 693-702.
[9]	Darsika C, Sowmya K, Suganya K, Grace X, Shanmuganathan S. Preparation and evaluation of herbal peel off face material. American Journal of PharmTech Research. 2015; 5(4): 33-336.
[10]	Nilforoushzadeh MA, Amirkhani MA, Zarrintaj P, et al. Skin care and rejuvenation by cosmeceutical facial material. J Cosmet Dermatol. 2018; 17(5): 693-702.
[11]	Fabbrocini G, Capasso C, Donnarumma M, et al. A peel-off facial material comprising myoinositol and trehalose-loaded liposomes improves adult female acne by reducing local hyperandrogenism and activating autophagy. J Cosmet Dermatol. 2017; 16(4): 480-484.
[12]	Youn Seok Na et al. Effect of ethanol extract from mixture including Angelicae Dahuricae Radix on Dermal Anti-aging and Whitening [J]. The Korea Journal of Herbology, 2019, 34(6): 109-115.
[13]	Jin Bei et al. The synergistic effect of high pressure processing and pectin on the physicochemical stability and antioxidant properties of biopolymer complexes composed of soy protein and coumarin [J]. Process Biochemistry, 2021, 104 (prepublish).
[14]	Perugini P, Bleve M, Redondi R, et al. In vivo evaluation of the effectiveness of biocellulose facial materials as active delivery systems to skin. J Cosmet Dermatol. 2020; 19(3): 725-735.
[15]	Meier L, Stange R, Michalsen A, et al. Clay jojoba oil facial material for lesioned skin and mild acne-results of a prospective, observational pilot study. Forsch Komplementmed. 2012; 19(2): 75-79.
[16]	DENIS M C, KATHY G, CLARE H, et al. Tyrosine kinase inhibitors as modulators of trastuzumab - mediated antibodydependent cell - mediated cytotoxicity in breast cancer cell lines [J]. Cellular Immunology, 2017, 319: 35-42.
[17]	Ngoenkratok J, Worachuen P, Puapermpoonsiri U, Silaon W. The influence of ethanol content on physical characteristics and mechanical properties of facial peel off material contained the ethanolic extract of Centella asiatica (Linn.) Urban. Isan J Pharm Sci. 2015; 11(1): 347-352.
[18]	O'Reilly Beringhs A, Rosa JM, Stulzer HK, et al. Green clay and aloe vera peel-off facial materials: response surface methodology applied to the formulation design. AAPS PharmSciTech. 2013; 14(1): 445-455.
[19]	Beringhs A, Rosa JM, Stulzer HK, Budal RM, Sonaglio D. green clay and aloe vera peel-off facial materials: response surface methodology applied to the formulation design. AAPS PharmSciTech. 2013; 14 (1): 445-455.
[20]	Velasco M, Vieira R, Fernandes A, et al. Short-term clinical of peel-off facial material moisturizers. Int J Cosmet Sci. 2014; 36 (4): 355-360.
[21]	Lilis Kistriyani, Achmad Chafidz Mas Sahid, Tintin Mutiara, et al. Characteristic of Membrane from Purple Sweet Potato (Ipomea batatas) as Antioxidant Face material. Key Engineering Materials, 2018; 4687: 354-359.
[22]	Hakozaki T, Minwalla L, Zhuang J, et al. The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer. Br J Dermatol. 2002; 147(1): 20-31.
[23]	Panico A, Serio F, Bagordo F, et al. Skin safety and health prevention: an overview of chemicals in cosmetic products. J Prev Med Hyg. 2019; 60(1): E50-E57.
[24]	Amso, Z., Kowalczyk, R., Watson, M., et al. Structure activity relationship study on the peptide hormone preptin, a novel bone-anabolic agent for the treatment of osteoporosis. Org Biomol Chem 2016, 14 (39), 9225-9238.
[25]	Zhang, C., Zhang, Y., Wang, Z., et al. Production and identification of antioxidant and angiotensin-converting enzyme inhibition and dipeptidyl peptidase IV inhibitory peptides from bighead carp (Hypophthalmichthys nobilis) muscle hydrolysate. Journal of Functional Foods 2017, 35, 224-235.
[26]	Balkhi B, Seoane-Vazquez E, Rodriguez-Monguio R. Changes in the utilization of osteoporosis drugs after the 2010 FDA bisphosphonate drug safety communication. Saudi Pharmaceutical Journal. 2018, 26(2): 238-243.
[27]	Mary A. Ajatta et al. Effect of Roasting on the Phytochemical Properties of Three Varieties of Marble Vine (Dioclea reflexa) Using Response Surface Methodology[J]. Preventive Nutrition and Food Science, 2019, 24(4): 468-477.
[28]	Mohammadi, R., Mohammadifar, M. A., Mortazavian, A. M., et al. Extraction optimization of pepsin-soluble collagen from eggshell membrane by response surface methodology (RSM). Food Chem 2016, 190, 186-193.
[29]	Guo, Y., Pan, D., Tanokura, M., Optimisation of hydrolysis conditions for the production of the angiotensin-I converting enzyme (ACE) inhibitory peptides from whey protein using response surface methodology. Food Chemistry 2009, 114 (1), 328-333.
[30]	Tahmouzi, S., Optimization of polysaccharides from Zagros oak leaf using RSM: antioxidant and antimicrobial activities. Carbohydr Polym 2014, 106, 238-46.
[31]	Cho, S. M., Gu, Y. S., Kim, S. B., Extracting optimization and physical properties of yellowfin tuna (Thunnus albacares) skin gelatin compared to mammalian gelatins. Food Hydrocolloids 2005, 19 (2), 221-229.
[32]	Bezerra, M. A., Santelli, R. E., Oliveira, E. P., et al. Response surface methodology (RSM) as a tool for optimization in analytical chemistry. Talanta 2008, 76 (5), 965-77.
[33]	Carballo-Sánchez Marco P et al. The Radical-Scavenging Activity of a Purified and Sequenced Peptide from Lactic Acid Fermentation of Thunnus albacares By-Products. [J]. Applied biochemistry and biotechnology, 2019, 189(4): 1084-1095.
[34]	Hou, T., Wang, C., Ma, Z., Shi, W., Weiwei, L., & He, H. (2015). Desalted duck egg white peptides: Promotion of calcium uptake and structure characterization. Journal of Agricultural and Food Chemistry, 8170-8176.
[35]	Wu, W., Li, B., Hou, H., Zhang, H., & Zhao, X. (2017). Identification of iron-chelating peptides from Pacific cod skin gelatin and the possible binding mode. Journal of Functional Foods, 35, 418-427.
[36]	Guo, L., Harnedy, P. A., O’Keeffe, M. B., Zhang, L., Li, B., Hou, H., & FitzGerald, R. J. (2015). Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides. Food Chemistry, 173, 536-542.
[37]	Guo Zebin et al. In Vitro Antioxidant Activity and In Vivo Anti-Fatigue Effect of Sea Horse (Hippocampus) Peptides. [J]. Molecules (Basel, Switzerland), 2017, 22(3).
[38]	Li B, Zhang X, Wang J, et al. Simuitaneo us characterisation of fifty coumarins from the roots of Angelica dahurica by off-line two-dimensional high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry [J]. Phytochem Anal, 2014, 25(3): 229.
[39]	Ji Joong Gu and Yoo Sun Kyun. Antioxidant properties of Angelica dahurica extracts fermented by probiotics strains isolated from gimchi [J]. Journal of the Korean Applied Science and Technology, 2018, 35(4): 1276-1284.
[40]	Ambreen et al. Biotransformation of newly synthesized coumarin derivatives by Candida albicans as potential antibacterial, antioxidant and cytotoxic agents [J]. Process Biochemistry, 2019, 87: 138-144.
[41]	Xu, Z., Zhu, Z. X., Chen, H., Han, L. Y., Shi, P. J., Dong, X. F., … Li, T. T. (2022). Application of a Mytilus edulis-derived promoting calcium absorption peptide in calcium phosphate cements for bone. Biomaterials, 282.
[42]	Choi K T, Kim J H, Cho H T, et al. Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract [J]. Journal of Cosmetic Dermatology, 2016, 15(2): 162-168.
[43]	Fan L, He C, Jiang L, et al. Brief analysis of causes of sensitive skin and advances in evaluation of anti-allergic activity of cosmetic products[J]. International Journal of Cosmetic Science, 2016, 38(2): 120-127.