Effect of Azilsartan, Aliskiren or Their Combination on Body Weight and Adipogenesis of High-fat Diet Induced Non-alcoholic Fatty Liver Disease in Rats

Rabab M. Utba¹, Saad A. Hussain^1, , Ammar A. Fadhil¹ and Angham Ahmed¹

¹Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq

Cite this paper:
Rabab M. Utba, Saad A. Hussain, Ammar A. Fadhil and Angham Ahmed. Effect of Azilsartan, Aliskiren or Their Combination on Body Weight and Adipogenesis of High-fat Diet Induced Non-alcoholic Fatty Liver Disease in Rats. American Journal of Pharmacological Sciences. 2016; 4(3):31-34. doi: 10.12691/ajps-4-3-1

Abstract

The renin-angiotensin system (RAS) plays an important role in the pathophysiology of many diseases including non-alcoholic fatty liver disease (NAFLD). This study aims to evaluate the effects of blocking RAS with azilsartan, aliskiren or their combination on the body weight and adipogenesis in rat’s model of NAFLD. Thirty-two rats were allocated into four groups and treated with either vehicle, azilsartan, aliskiren or their combination. All groups were maintained on high-fat diet for 60 days, and their body weights were monitored each 3 days. At the end of treatment all animals were authenticated and visceral adipose tissues obtained and weighed. Azilsartan attenuates both the increase in total body and adipose tissue weight compared with control, while azilsartan alone affects adipogenesis only. In conclusion, Administration of azilsartan attenuates adipogenesis and obesity in rat’s model of high-fat diet induced NAFLD, while aliskiren affects adipogenesis only.

Keywords:
high-fat diet NAFLD azilsartan aliskiren adipogenesis

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