The Antidepressant-like Action of Human and Caprine Amniotic Fluid in Rats: Effect of Gender

Badreldin H. Ali^1, , Abdullah M. Alsaidi¹, Saniya El Tayeb² and Mohamed H. Tageldin³

¹Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Muscat, Sultanate of Oman

²Department of Obstetrics and Gynecology, College of Medicine and Health Sciences, Sultan Qaboos University, Al-Khod, Muscat, Sultanate of Oman

³Department of Animal and Veterinary Sciences, College of Agricultural and Marine Sciences, Sultan Qaboos University, Al-Khod, Muscat, Sultanate of Oman

Cite this paper:
Badreldin H. Ali, Abdullah M. Alsaidi, Saniya El Tayeb and Mohamed H. Tageldin. The Antidepressant-like Action of Human and Caprine Amniotic Fluid in Rats: Effect of Gender. American Journal of Pharmacological Sciences. 2015; 3(4):98-102. doi: 10.12691/ajps-3-4-3

Abstract

Depression is a common worldwide burdening mental disease. The amniotic fluid (AF) in both humans and animals has been reported to be associated with reduction of anxiety, pain and with helping the newborns to recognize their mothers. As far as we know, no published work on its possible antidepressant action has been reported before. Therefore, we tested here if AF has an anti-depressant- like activity, and investigated if there is a gender difference in this action. Also, we wanted to find out if this possible action can be modified by a known antidepressant drug. Sixty male and female Wister rats were divided randomly into five groups in each gender, and treated with the following: water (control), human AF, goat AF, venlafaxine and venlafaxine+ human AF. AF and venlafaxine were given orally by gavage at a dose of 0.2ml/ Kgonce a day for five days. Twenty four hours later, locomotor activity test, and the forced swimming test (FST) were measured. Motor activity and immobility time in the FST were both significantly reduced in male and female rats treated with human and caprine AF. Rats treated with human AF showed the least activity. The latter effects were not significantly affected by concomitant treatment with venlafaxine and human AF. The biochemical mechanisms of antidepressant like effect of AF warrant further study.

Keywords:
depression forced swimming test amniotic fluid motor activity rats

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