Estimation of LD50 and Acute Toxicity of Zygophyllum fabago in Mice

Hasan Alhaddad^1, , Ammar Amer Fadhil¹ and Sajida H Ismael¹

¹Department of Pharmacology and Toxicology, College of Pharmacy, University of Baghdad, Baghdad, Iraq

Cite this paper:
Hasan Alhaddad, Ammar Amer Fadhil and Sajida H Ismael. Estimation of LD50 and Acute Toxicity of Zygophyllum fabago in Mice. American Journal of Pharmacological Sciences. 2015; 3(4):94-97. doi: 10.12691/ajps-3-4-2

Abstract

Zygophyllum fabago, a member of the genus Zygophyllum, has lonely used in traditional medicine in Iraq for the treatment of many diseases. However, no studies have done to evaluate the acute toxicity of its extract. Thus, we designed this study to examine its acute toxicity and LD-50 value in mice depending on OECD 423 guidelines for testing of chemicals. Twenty-one mice were given Zygophyllum fabago extract in doses of 2000 or 5000 mg/kg. The results showed that both doses of Zygophyllum fabago extract did not show any toxic signs or mortality. Moreover, body weights and relative organs weight were not affected. Furthermore, it did not induce kidney and liver injuries. Therefore, results of this study suggested that Zygophyllum fabago extract is safe within the tested doses and did not produce acute toxicity when administered orally as a single dose.

Keywords:
Acute oral toxicity Zygophyllum fabago LD-50 OECD423

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