Antioxidant Effects of Picrorhiza kurrooa Rhizome Extracts in Alcoholic Cirrhosis of Liver

Neelesh Deshpande¹, Raj kumar Das¹, Manohar muddeshwar¹, Vaishali Das¹, Sabitha Kandi² and K V Ramana^3,

¹Department of Biochemistry, Government Medical College and Superspeciality hospital, Nagpur, India

²Department of Biochemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India

³Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India

Cite this paper:
Neelesh Deshpande, Raj kumar Das, Manohar muddeshwar, Vaishali Das, Sabitha Kandi and K V Ramana. Antioxidant Effects of Picrorhiza kurrooa Rhizome Extracts in Alcoholic Cirrhosis of Liver. American Journal of Pharmacological Sciences. 2015; 3(2):49-51. doi: 10.12691/ajps-3-2-4

Abstract

Picrorhiza kurrooa is mentioned in Ayurveda for the treatment of many disorders, but it has not been subjected to systematic scientific investigations to assess its antioxidant activity and hepatoprotective properties in alcoholic cirrhosis of liver. The methanol extracts of P. kurrooa Rhizomes significantly reduced oxidative stress and elevated antioxidants which were measured spectrophotometrically. The results of the study revealed that there was significant reduction in the activities of liver enzymes among the liver cirrhosis patients after the treatment with the P Kurrooa plant extract. The post-treatment results also showed significant correlation in the activities of malondialdehyde, glutathione peroxidase and superoxide dismutase in the liver of alcoholic patients.

Keywords:
Picrorhiza kurrooa antioxidant activity alcoholic cirrhosis of liver

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