Optimization and Permeation Study of Novel Topically Applied Antilipemic Lotion Using Central Composite Design

Asma Aslam¹, Rummana Riaz¹, Yasser Shahzad², Atif Akber³, Ikram Ullah Khan^4, and Syed Nisar Hussain Shah⁵

¹Multan College of Pharmacy and Management Sciences, Pakistan

²Centre of Excellence for Pharmaceutical Sciences, North-West University, South Africa

³Department of Statistics, Bahauddin Zakariya University, Multan, Pakistan

⁴College of Pharmacy, Government College University, Faisalabad, Pakistan

⁵Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan

Cite this paper:
Asma Aslam, Rummana Riaz, Yasser Shahzad, Atif Akber, Ikram Ullah Khan and Syed Nisar Hussain Shah. Optimization and Permeation Study of Novel Topically Applied Antilipemic Lotion Using Central Composite Design. American Journal of Pharmacological Sciences. 2014; 2(5A):8-14. doi: 10.12691/ajps-2-5A-2

Abstract

In this study, synergistic effect of penetration enhancers, namely propylene glycol (PG) and sodium lauryl Sulphate (SLS) on transdermal absorption of 2-Methyl-2-phenoxy-propionic acid (MPA) was evaluated with aid of response surface methodology (RSM) based formulations. The prepared formulations were characterised and subsequently subjected to diffusion cell experiments through a well-established skin mimic, namely silicone membrane. Data obtained were statistically analysed using analysis of variance (ANOVA) and regression analysis. Comparisons were made with the control and among different parameters of formulations. PG (X1) and SLS (X2) were selected as independent variables, whereas the cumulative amount of MPA were used to calculate dependent permeation kinetic parameters like lag time (t_lag) and enhancement ratios (ER). It was observed from the results that PG had a significant effect on MPA absorption from the lotion followed by SLS and their combination showed a significant enhancement (p< 0.05) in the flux from the formulated lotions compared to the control. The highest enhancement ratio (ER=8.6) was observed for L4. Contour plots were then drawn to depict the relationship between independent and response variables. Among the formulations, L4 showed highest flux value with less lag time (12.2 min), thereby, identified and selected as an optimized formulation. In conclusion, the combination of PG and SLS can be successfully utilized as permeation enhancers for transdermal drug delivery of MPA with minimal side effects.

Keywords:
propylene glycol sodium lauryl sulphate permeation response surface methodology lotion

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