Comparative Effect of Cold Hydro Stem-Bark Extract of Erythrophleum Suaveolens on Gastrointestinal Muscle of Rabbit Jejunum (Oryctolagus Cuniculus)

Ogundeko O Timothy¹, Ramyil M Seljul^2, , Idyu C Vivian³ and Idyu I Isaiah⁴

¹Department of Pharmacology and Therapeutics, College of Health Sciences, Bingham University, Jos, Nigeria

²Department of Medical Microbiology, College of Health Sciences, Bingham University, Jos, Nigeria

³Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria

⁴Department of Pharmacology, Faculty of Pharmaceutical Sciences, University of Jos, Nigeria

Cite this paper:
Ogundeko O Timothy, Ramyil M Seljul, Idyu C Vivian and Idyu I Isaiah. Comparative Effect of Cold Hydro Stem-Bark Extract of Erythrophleum Suaveolens on Gastrointestinal Muscle of Rabbit Jejunum (Oryctolagus Cuniculus). American Journal of Pharmacological Sciences. 2014; 2(3):52-55. doi: 10.12691/ajps-2-3-2

Abstract

Detailed investigations on plant materials especially such that are already in use especially by tradio-practitionals should not be taken with levity. The effect of cold water crude extract of stem-bark of Erythrophleum suaveolens on the activity of an isolated rabbit jejunum was studied. Reference drugs (Adrenaline and Isoprenaline) were used both in the presence and absence of E. suaveolens extract. Preliminary pharmacological investigation of the extract revealed inhibitory effects. However, the relaxative effect of the extract on isolated smooth muscle was confirmed from its cumulative response on Rabbit jejunum in which there was a graded inhibition of the jejunal contraction even up to 95% - 95.5%. The result of the study therefore suggest that the extract has the potential of been develop as an anti-motility agent as a remedy for GIT system related problems.

Keywords:
Erythrophleum suaveolens Oryctolagus cuniculus Gastrointestinal Muscle Jejunum Inhibitory effect

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