Salidiuretic Effect and Diuretic Mechanism of Action of an Aqueous Extract of Saccharum Officinarum Leaves (Poaceae) in Rats

Irié bi jean séverin^1, , Kouakou Assui Aude Ines¹, Kassi yomalan¹ and Abo kouakou Jean-Claude¹

¹Laboratory of Biology and Health, Felix HOUPHOUET-BOIGNY University, 22 BP 582 Abidjan 22, Ivory Coast

Cite this paper:
Irié bi jean séverin, Kouakou Assui Aude Ines, Kassi yomalan and Abo kouakou Jean-Claude. Salidiuretic Effect and Diuretic Mechanism of Action of an Aqueous Extract of Saccharum Officinarum Leaves (Poaceae) in Rats. American Journal of Pharmacological Sciences. 2023; 11(2):44-48. doi: 10.12691/ajps-11-2-3

Abstract

Saccharum officinarum L (Poaceae) is a plant whose leaves are used as a diuretic and in the traditional treatment of high blood pressure. This study aims to evaluate the salidiuretic effect of the aqueous extract of Saccharum officinarum (Esol) leaves and detect its mechanism of action in rats. The effect of the dose of 1000 mg / kg BW is compared to those of furosemide (40 mg / kg BW), Esidrex (25 mg / kg BW) and Aldactone (50 mg / kg BW) on the concentration of Na⁺, K⁺ and Cl^- ions in 24-hour urine produced by rats placed on water overload. The results show that the 24-hour urinary volume increases significantly (p < 0.001) with Esol (16.22 ± 1.89 mL) as do the diuretics used compared to the control. The determination of Na⁺, K⁺ and Cl^- ions in the urine of animals treated with Esol gives respective concentrations of 2.65 ± 0.34; 0.23 ± 0.05 mEq / L and 2.67 ± 0.253 mEq / L variations significantly close to those of Aldactone. The pH of urine obtained with Esol and reference diuretics is basic. The Na⁺ / K⁺ ratio of Esol (11.27) like that of Aldactone (10.63) is greater than 10.These parameters confirm that the aqueous extract of Saccharum officinarum leaves has salidiuretic properties acting as a sparing agent potassium just like (Aldactone). These results therefore justify the use of Saccharum officinarum leaves in traditional medicine.

Keywords:
Saccharum officinarum salidiuretic potassium sparing basic pH Aldactone

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