American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: https://www.sciepub.com/journal/ajps Editor-in-chief: Srinivas NAMMI
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American Journal of Pharmacological Sciences. 2023, 11(2), 28-34
DOI: 10.12691/ajps-11-2-1
Open AccessArticle

Larval and Acute Oral Toxicity of Calotropis Procera and Ficus Umbellata, Plants Traditionally Used to Treat Hemorrhoids in Benin

Yomakou Bato Georges G. René1, Glinma Bienvenu2, Assogba M. Fidèle1, Akakpo Baï Huguette1, 3, Ahoton Djidénou1, Ahounou Aïkpé Judith Fifamin3, Yayi Ladekan Eléonore1, Salomé D.S. Kpoviessi2 and Gbenou D. Joachim1, 4,

1Laboratoire de Pharmacognosie et des Huiles Essentielles (LaPHE), 01 BP 526 Cotonou, Département de Chimie, Faculté des Sciences et Techniques (FAST), Université d'Abomey-Calavi (UAC), Champ de Foire, Bénin

2Laboratoire de Chimie Organique Physique et de Synthèse (LaCOPS), 01 BP 526 Cotonou, Département de Chimie, Faculté des Sciences et Techniques (FAST), UAC, Abomey-Calavi, Bénin

3Laboratoire de Physiologie de l'Effort, Institut National de la Jeunesse, de l'Education Physique et Sportive, Université d'Abomey-Calavi, 01 BP 169 Porto-Novo, République du Bénin

4Département de Chimie, Université Nationale des Sciences, Technologies, Ingénierie et Mathématiques, Abomey, Bénin

Pub. Date: October 07, 2023

Cite this paper:
Yomakou Bato Georges G. René, Glinma Bienvenu, Assogba M. Fidèle, Akakpo Baï Huguette, Ahoton Djidénou, Ahounou Aïkpé Judith Fifamin, Yayi Ladekan Eléonore, Salomé D.S. Kpoviessi and Gbenou D. Joachim. Larval and Acute Oral Toxicity of Calotropis Procera and Ficus Umbellata, Plants Traditionally Used to Treat Hemorrhoids in Benin. American Journal of Pharmacological Sciences. 2023; 11(2):28-34. doi: 10.12691/ajps-11-2-1

Abstract

In the modern days, investigation of the phytochemical compounds contained in the traditionally-acknowledged medicinal plants have established significant interest in drug research and developmental projects. In addition, phytochemical compounds in plants are compounds delivered by plants having pharmacological or toxicological properties in man and animals. Calotropis procera (Ait.) and Ficus umbellata (Vahl.) are two medicinal plants used in Benin. Their various preparations were used to treat a number of ailments and diseases, including hemorrhoids. Here, before checking their effects on hemorrhoids, toxicity studies were carried out on the decoction of F. umbellata leaves and those of C. procera with and without potash as used in the traditional treatment of hemorrhoids in Benin. Toxicity test results demonstrated tolerance of the leaves to Artemia salina larvae with all their LC50 > 0.10 mg/mL (0.147 for extract of F. umbellata, 0.224 for extract without potash of C. procera and 0.887 for extract with potash of C. procera) and albino rats of the wistar strain in acute oral toxicity at a single dose of 2000 mg/kg body weight. Studies of chronic and sub-chronic toxicity, as well as the anti-inflammatory activity of the extracts, are in prospect.

Keywords:
medicinal plants extracts phytochemistry toxicity cytotoxicity

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