A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats

Nagiat T Hwisa¹, Fathi H Assaleh¹, Sumalatha Gindi², Fauzi El Melad¹, Babu Rao Chandu^{1, 3,} and Prakash Katakam^{1, 3}

¹Faculty of Pharmacy, University of Zawia, Az Zawiyah, Libya

²Department of Pharmacology, Hindu College of Pharmacy, Guntur, India

³Priyadarshini Institute of Pharmaceutical Education and Research, Guntur, India

Cite this paper:
Nagiat T Hwisa, Fathi H Assaleh, Sumalatha Gindi, Fauzi El Melad, Babu Rao Chandu and Prakash Katakam. A Study on Antiurolithiatic Activity of Melia Azadirachta L. Aqueous Extract in Rats. American Journal of Pharmacological Sciences. 2014; 2(1):27-31. doi: 10.12691/ajps-2-1-6

Abstract

The objective was to investigate the antiurolithiatic activity of aqueous plant extract of Melia azadirachta using the zinc disc implantation model in male Wistar albino rats. A significant increase in urinary excretion of calcium, oxalate, magnesium and phosphate was observed after four weeks of implantation of zinc discs. After treatment with aqueous extract of Melia azadirachta caused a significant reduction (p < 0.001) in stone weight and urinary excretion of electrolytes in both the preventive and curative group of animals as compared to those of control groups. This explains the effect of the aqueous extract of Melia azadirachta in preventing urolithiasis (59%) and dissolving the pre-formed magnesium ammonium phosphate type of stones (46%). The possible mechanism could be due to the urinary stone-formation, lowering, antioxidant, diuretic, nephroprotective constituents present in Melia azadirachta. These results suggest the usefulness of aqueous plant extract of Melia azadirachta as an antiurolithiatic agent.

Keywords:
Melia azadirachta antiurolithiatic activity aqueous extract rats

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