Contribution to the Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of Covid-Organics

Elion Itou RDG^{1, 2,} , Etou Ossibi AW^{1, 3}, Morabandza CJ⁴, Boumba Y¹ and Abena AA³

¹Laboratory of Pharmacodynamics and Experimental Physiopathology, Faculty of Sciences and Techniques, Marien Ngouabi University, BP 69, Brazzaville-Congo

²National Institute for Research in Health Sciences, Scientific City of Brazzaville (ex- ORSTOM), route de l’auberge de Gascogne château d’eau, Congo;Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, BP 69, Brazzaville-Congo

³Laboratory of Biochemistry and Pharmacology, Faculty of Health Sciences, Marien Ngouabi University, BP 69, Brazzaville-Congo

⁴Department of Natural Sciences, Ecole Normale Supérieure, Marien Ngouabi University, B.P 69, Brazzaville - Congo

Cite this paper:
Elion Itou RDG, Etou Ossibi AW, Morabandza CJ, Boumba Y and Abena AA. Contribution to the Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of Covid-Organics. American Journal of Pharmacological Sciences. 2023; 11(1):1-7. doi: 10.12691/ajps-11-1-1

Abstract

Covid-Organics is an improved traditional medicine made from a plant called Artemisia annua Linn. It is developed by the Malagasy Institute for Applied Research with the aim is to treat coronavirus disease or Covid-19. The present study aims to justify the use of Covid-Organics by evaluating the anti-inflammatory, analgesic and antipyretic activities. Acute inflammation was induced by using the carrageenan and formaldehyde models. The results obtained show that Covid-Organics at the doses used significantly reduces (p<0.05; p<0.01; p<0.001) the edema induced by carrageenan and formaldehyde. Chronic inflammation was evalueted using the model of formaldehyde induced arthritis in rat. Results obtained show that Covid-Organics and diclofenac (standard drug) significantly reduce (p<0.001) the evolution of edema throughout the period of the experiment compared to the control group. The analgesic effect was evaluated by using the method of acetic acid and formaldehyde induced pain. Covid-Organics significantly reduced (p<0.001) the number of abdominal writhing induced by acetic acid, as well as the number of formaldehyde-induced paw licking and biting (p<0.01 and p<0.001). The antipyretic effect was induced using brewer's yeast induced pyrexia. The results obtained showed that Covid-Organics (0.6 and 1.2 mL/100g) increased significantly (p < 0.05; p < 0.01 and p < 0.001) pyrexia induced by brewer's yeast compared the control group. In conclusion, Covid-Organics (0.6 and 1.2 mL/100g) has anti-inflammatory, analgesic and antipyretic effects. These observations justify justify the use of Covid-Organics against the symptoms of coronavirus disease.

Keywords:
anti-inflammatory analgesic antipyretic Covid-Organics

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