American Journal of Pharmacological Sciences
ISSN (Print): 2327-6711 ISSN (Online): 2327-672X Website: Editor-in-chief: Srinivas NAMMI
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American Journal of Pharmacological Sciences. 2022, 10(1), 12-19
DOI: 10.12691/ajps-10-1-3
Open AccessArticle

Comparative Study of Clinical Effect of Kshara-Basti and Virechana-Karma in the Management of Amavata with Special Reference to Rheumatoid Arthritis

Rahul Dalavi1, 2, , Pushpinder Singh1, Anil Pardeshi3, Md. Hanif Shaikh4, Shubhangi Narwade2 and Pallavi Pardeshi5

1Department of Panchakarma, Rajiv Gandhi Government Post-graduate Ayurveda College, Paprola, Himachal Pradesh, India

2Department of Panchakarma & Swasthavritta, Bharat Ayurveda Medical College, Muzaffarnagar, Uttar Pradesh, India

3KVP Gangadhar-Shastri Gune Ayurveda College, Ahmednagar, India

4Department of Pharmacology, Dr. D. Y. Patil Institute of Pharmaceutical Sciences and Research, Pune, India

5Chhatrapati Shahu Maharaj Shikshan Sanstha (CSMSS) Ayurveda College, Aurangabad, India

Pub. Date: July 07, 2022

Cite this paper:
Rahul Dalavi, Pushpinder Singh, Anil Pardeshi, Md. Hanif Shaikh, Shubhangi Narwade and Pallavi Pardeshi. Comparative Study of Clinical Effect of Kshara-Basti and Virechana-Karma in the Management of Amavata with Special Reference to Rheumatoid Arthritis. American Journal of Pharmacological Sciences. 2022; 10(1):12-19. doi: 10.12691/ajps-10-1-3


Background: Kshara Basti and Virechana Karma as therapy for Amavata are indicated in Ayurveda. Ayurveda is having a crucial role in the management of Amavata with special reference to rheumatoid arthritis (RA) as a crippling disease. Amavata is having clinical appearance as comparable with RA. The line of treatment as mentioned by Chakradatta is to bring Agni to normal state for digestion of Ama, eventually to eliminate vitiated Vata and Ama. Thus, here Kshara Basti and Virechana Karma are selected for the present study as Samshodhana process which corrects all the above captions. Objective: To evaluate and compare clinical efficacy of Kshara Basti and Virechana Karma as tharapy in Amavata. Methods: This was a randomized open-label, comparative clinical study. Total 35 randomly selected patients of Amavata were registered and screened and out of them 30 (15 patients in Group-A i.e. Kshara Basti and 15 patients in Group-B i.e. Virechan-Karma) were completed the treatment. Kshara Basti in the format of Kala Basti (as mentioned by Chakradatta) was given to the patients of Basti group and Virechana Karma as per Chakradatta was given to the patients of Virechana karma group. The effects of therapy in both groups were assessed by a specially prepared proforma. Results: The results of the study showed that both the groups showed significant relief in symptoms; however, compared to Virechana karma group, Basti group showed better result in the management of Amavata. Statistically significant improvement was found in ESR, RA factor (quantitative) and highly significant results were found in symptoms of Amavata (Kshara Basti results significant as compared to Virechana karma). Moderate improvement was seen in 80% of patients of Basti group (66.6% Virechana karma group), 6.6% patients got marked improvement in Basti group (no marked improvement in Virechana group), while mild improvement was found in 13.3% of patients of Basti group (33.3% for Virechana karma group). Conclusion: Kshara Basti and Virechana Karma have significant comparative activity in Amavata.

complementary and alternative medicines amavata Kshara Basti Virechana Karma Ayurveda rheumatoid arthritis

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[1]  Shastri K, Chaturvedi GN, Ed. Dridhabala, Charak Samhita of Agnivesh, Siddhi Sthana. Reprint edition. Ch. 1, Ver. 38-40. Varanasi: Chaukhabha Bharati Academy; p. 1169, (2003).
[2]  Harrison TR, Dennis L. Casper, Anthony, Bn Dan L Longo, Eugene Braunwald, Stephen L. Hauser, J. Larry Jameson, et al. Harrison’s Principles of Internal Medicine. Braunwald, editor. 15th ed, Vol. 2, Part 12. New York: McGraw Hill organization; p. 1928, (2001).
[3]  Malaviya AN, Kapoor SK, Singh RR, Kumar A, Pande I, (1993). Prevalence of rheumatoid arthritis in the adult Indian population. Rheumatol Int; 13(4).
[4]  Dr. Indradeva Tripathi, editor. Acharya Ramanatha Dwevedi. Chakrapani Dutta, Chakradutta-Vaidya Prabha Hindi commentary with explanation, 4th ed. Chakradutta 25/1. Varanasi: Chowkhambha Sanskrit Sansthana; p.166, (2002).
[5]  Shastri BS, editor. Yogaratnakara of unknown author, Amavata Chikitsa. 6th ed., vol. Varanasi: Chaukhamba Sanskrit Sansthan; p. 566-73, (1997).
[6]  Shastri Sudarshana, Ed. Madhava Nidana of Madhavakara. 29th ed. Ch. 25, ver. 6. Varanasi: Chaukhambha Sanskrit Samsthan; p. 511, (1999).
[7]  Shri Sudarshana Shastri revised and edited by Prof. Yadunandan Upadhayay. Madhava Nidana of Shri Madhavakara with the Madhukosha Sanskrit commentary by Srivijayarakshita and Srikanthadatta with the Vidyotani Hindi commentary and notes by. 27th ed. Varanasi: Chaukhambha Sanskrit Samsthana; Amavata Nidana 25/6-11, P. 462-3, (1998).
[8]  Christopher Haslett, Edwin R Chilvers, Nicholas A Boon and Nicki R Colledge, Davidson’s Principle and Practice of Medicine. 19th edition Philladelphia, Churchill livingstone, p 1002-1007, (2002).
[9]  Bralulnwalad, Fauci, Kasper, Hauser, Longo and Jameson, Harrison`s principles of Internal medicine, Table 312-1, 15th International edition volume 2, New York, McGraw-Hill medical publication, p 1934, (2001).
[10]  Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, & et al, (1988). The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum; 31: 315-24.
[11]  Sasane P, Saroj UR, Joshi RK, 2016.Clinical evaluation of efficacy of Alambushadi Ghana Vati and Vaitarana Basti in the management of Amavata with special reference to rheumatoid arthritis. AYU; 37: 105-112.
[12]  Thanki K, Bhatt N & Shukla VD, (2012). Effect of Kshara Basti and Nirgundi Ghana Vati on Amavata (Rheumatoid Arthritis). AYU; 33:50-53.
[13]  Pandey SA, Joshi NP & Pandya DM, 2012.Clinical efficacy of Shiva Guggulu and Simhanada Guggulu in Amavata (Rheumatoid Arthritis). AYU; 33: 247-254.
[14]  Khagram R, Mehta CS, Shukla VD, Dave AR, (2010). Clinical effect of Matra Basti and Vatari Guggulu in the management of Amavata (rheumatoid arthritis). AYU; 31: 343-350.