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American Journal of Public Health Research. 2024, 12(3), 48-53
DOI: 10.12691/ajphr-12-3-2
Open AccessArticle

Methicillin-Resistant Staphylococcus Aureus (Mrsa) Remains a Major Threat to Public Health

Mahendra Pal1, , Tesfaye Rebuma2, Temesgen Regassa3 and Ravindra Zende4

1Narayan Consultancy of Veterinary Public Health, and Microbiology, Bharuch, Gujarat, India

2Shaggar City administration Sebeta Sub city Agricultural office, Sebeta, Oromia, Ethiopia

3East Wallaga Zone, Wayu Tuka District Agricultural Office, Nekemte, Oromia, Ethiopia

4Department of Veterinary Public Health and Epidemiology, Mumbai Veterinary College, Mumbai, India

Pub. Date: August 08, 2024
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Cite this paper:
Mahendra Pal, Tesfaye Rebuma, Temesgen Regassa and Ravindra Zende. Methicillin-Resistant Staphylococcus Aureus (Mrsa) Remains a Major Threat to Public Health. American Journal of Public Health Research. 2024; 12(3):48-53. doi: 10.12691/ajphr-12-3-2

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) represents a major public health challenge due to its antibiotic resistance and potential for severe infections in both humans and animals. This review examines the current state of MRSA as a global health threat, emphasizing its virulence factors, transmission mechanisms, and impact on public health. MRSA's resistance to methicillin and other antibiotics confounds treatment and control efforts primarily due to the encoding of penicillin-binding protein 2a (PBP2a) by the mecA gene which has a low affinity for β-lactams, resulting in resistance to the entire class of antibiotics. The ability of the bacterium to cause a spectrum of infections, from mild skin conditions to life-threatening diseases like toxic shock syndrome, pneumonia, , bacteremia and , highlights its clinical significance. MRSA's spread is facilitated by its presence in healthcare settings, community environments, and livestock, with significant implications for food safety and public health. The review underscores the urgent need for enhanced surveillance, novel treatment strategies, and effective infection control measures to combat MRSA's growing threat.

Keywords:
bacteremia endocarditis healthcare-associated infections methicillin-resistant public health Staphylococcus aureus

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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