American Journal of Nursing Research
ISSN (Print): 2378-5594 ISSN (Online): 2378-5586 Website: https://www.sciepub.com/journal/ajnr Editor-in-chief: Apply for this position
Open Access
Journal Browser
Go
American Journal of Nursing Research. 2016, 4(3), 69-73
DOI: 10.12691/ajnr-4-3-3
Open AccessReview Article

Omega-3 Fatty Acids as Complementary and Alternative Medicine for Depression: Literature Review

Anas Husam Khalifeh1,

1Nursing Department, Prince Hamzah Hospital, Ministry of Health, Amman, Jordan

Pub. Date: September 19, 2016

Cite this paper:
Anas Husam Khalifeh. Omega-3 Fatty Acids as Complementary and Alternative Medicine for Depression: Literature Review. American Journal of Nursing Research. 2016; 4(3):69-73. doi: 10.12691/ajnr-4-3-3

Abstract

Background: Depression is a common mental and psychological disorder, rise globally. Depressed patients may resort to other sources to decrease the symptoms without side effects like complementary and alternative medicine (CAM), The most commonly used CAM treatments in the United States for people who have depression is Omega-3 Long-Chain Polyunsaturated Fatty Acids (LCPUFA). The purpose of this paper to highlight and explore more information about the effectiveness of omega 3 folic acid on patients who diagnosed with depression. Methods: Literature review of Randomized Control Trails (RCTs) studies, articles have been recovered for review of computer searches, from 2006 to 2016, databases that were used: PubMed, Medline, Wiley, PsychInfo, EBSCO host, Ovid database, Cinahl, and Google Scholar. Articles were selected based on a set of eligibility criteria. Results: The literature review content eight RCTs studies according to eligibility criteria, there are studies support the evidence of the effectiveness of omega-3 and dose of omega-3 with depression disorder as a monotherapy and combining with an antidepressant. However, there are studies that shown the inverse result. Conclusions: Although there are studies showed Influence effectively, the using and role of omega-3 for depression still under debate.

Keywords:
depression depressive symptoms omega-3 omega-3 long-chain polyunsaturated fatty acids complementary and alternative medicine

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

References:

[1]  American Psychiatric Association [APA]. (2010). Practice guideline for the treatment of patients with major depressive disorder. 3rd ed. Arlington, VA: American Psychiatric Publishing.
 
[2]  American Psychiatric Association [APA]. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Arlington, VA: American Psychiatric Publishing.
 
[3]  Appleton, K., Rogers, P., & Ness, A. (2008). Is there a role for n-3 long-chain polyunsaturated fatty acids in the regulation of mood and behaviour? A review of the evidence to date from epidemiological studies, clinical studies and intervention trials. Nutrition Research Reviews, 21(01), 13-41.
 
[4]  Appleton, K., Rogers, P., & Ness, A. (2010). Updated systematic review and meta-analysis of the effects of n-3 long-chain polyunsaturated fatty acids on depressed mood. American Journal of Clinical Nutrition, 91(3), 757-770.
 
[5]  Barnes, P., Bloom, B., & Nahin, R. (2008). Complementary and alternative medicine use among adults and children: United States, 2007. National Health Statistics Reports, (12), 1-23.
 
[6]  Bishop, F., Yardley, L., & Lewith, G. (2008). Treatment appraisals and beliefs predict adherence to complementary therapies: A prospective study using a dynamic extended self-regulation model. British Journal Of Health Psychology, 13(4), 701-718.
 
[7]  Bowen, R. & Clandinin, M. (2002). Dietary low linolenic acid compared with docosahexaenoic acid alter synaptic plasma membrane phospholipid fatty acid composition and sodium-potassium ATPase kinetics in developing rats. Journal Of Neurochemistry, 83(4), 764-774.
 
[8]  Calder, P., Yaqoob, P., Harvey, D., Watts, A., & Newsholme, E. (1994). Incorporation of fatty acids by concanavalin A-stimulated lymphocytes and the effect on fatty acid composition and membrane fluidity. Biochem. J., 300(2), 509-518.
 
[9]  Freeman, M. P. (2012). Complementary and Alternative Medicine for Psychiatrists. Canadian Journal of Psychiatry, 57(7), 395-396.
 
[10]  Gertsik, L., Poland, R., Bresee, C., & Rapaport, M. (2012). Omega-3 Fatty Acid Augmentation of Citalopram Treatment for Patients With Major Depressive Disorder. Journal of Clinical Psychopharmacology, 32(1), 61-64.
 
[11]  Grenyer, B., Crowe, T., Meyer, B., Owen, A., Grigonis-Deane, E., Caputi, P., & Howe, P. (2007). Fish oil supplementation in the treatment of major depression: A randomised double-blind placebo-controlled trial. Progress In Neuro-Psychopharmacology And Biological Psychiatry, 31(7), 1393-1396.
 
[12]  Grosso, G., Galvano, F., Marventano, S., Malaguarnera, M., Bucolo, C., Drago, F., & Caraci, F. (2014). Omega-3 Fatty Acids and Depression: Scientific Evidence and Biological Mechanisms. Oxidative Medicine And Cellular Longevity, 2014, 1-16.
 
[13]  Helgason, C., & Sarris, J. (2013). Mind-body medicine for schizophrenia and psychotic disorders: a review of the evidence. Clinical Schizophrenia & Related Psychoses, 7(3), 138-148.
 
[14]  Hibbeln, J., Linnoila, M., Umhau, J., Rawlings, R., George, D., & Salem, N. (1998). Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics. Biological Psychiatry, 44(4), 235-242.
 
[15]  Jazayeri, S., Tehrani-Doost, M., Keshavarz, S., Hosseini, M., Djazayery, A., & Amini, H. et al. (2008). Comparison of therapeutic effects of omega-3 fatty acid eicosapentaenoic acid and fluoxetine, separately and in combination, in major depressive disorder. Australian And New Zealand Journal of Psychiatry, 42(3), 192-198.
 
[16]  John Mann, J. & Malone, K. (1997). Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients. Biological Psychiatry, 41(2), 162-171.
 
[17]  Kotwal, S., Jun, M., Sullivan, D., Perkovic, V., & Neal, B. (2012). Omega 3 Fatty Acids and Cardiovascular Outcomes: Systematic Review and Meta-Analysis. Circulation: Cardiovascular Quality and Outcomes, 5(6), 808-818.
 
[18]  Lee, C. R., & Hamm, M. W. (1989). Effect of dietary fat and cholesterol supplements on glucagon receptor binding and adenylate cyclase activity of rat liver plasma membrane. The Journal of nutrition, 119(4), 539-546.‏
 
[19]  Linden, M., Wurzendorf, K., Ploch, M., & Schaefer, M. (2008). Self medication with St. John's wort in depressive disorders: An observational study in community pharmacies. Journal of Affective Disorders,107(1), 205-210.
 
[20]  Massart, R., Mongeau, R., & Lanfumey, L. (2012). Beyond the monoaminergic hypothesis: neuroplasticity and epigenetic changes in a transgenic mouse model of depression. Philosophical Transactions Of The Royal Society B: Biological Sciences, 367(1601), 2485-2494.
 
[21]  Mischoulon, D., Best-Popescu, C., Laposata, M., Merens, W., Murakami, J., & Wu, S. et al. (2008). A double-blind dose-finding pilot study of docosahexaenoic acid (DHA) for major depressive disorder. European Neuropsychopharmacology, 18(9), 639-645.
 
[22]  Mischoulon, D., Papakostas, G., Dording, C., Farabaugh, A., Sonawalla, S., & Agoston, A. et al. (2009). A Double-Blind, Randomized Controlled Trial of Ethyl-Eicosapentaenoate for Major Depressive Disorder. The Journal of Clinical Psychiatry, 70(12), 1636-1644.
 
[23]  National Center for Complementary and Alternative Medicine [NCCAM]. (2008). Complementary, Alternative, or Integrative Health: What’s In a Name?. NCCAM. Retrieved 3 October 2014, from http://nccam.nih.gov/health/whatiscam
 
[24]  National Health Service [NHS]. (2012). About complementary medicines - Live Well - NHS Choices. Nhs.uk. Retrieved 17 October 2014, from http://www.nhs.uk/Livewell/complementary-alternative-medicine/Pages/complementary-alternative-medicines.aspx.
 
[25]  National Institute of Mental Health [NIMH]. (2012). NIMH • Statistics • Major Depression among Adults.Nimh.nih.gov. Retrieved 3 October 2014, from http://www.nimh.nih.gov /statistics/1mdd_adult.shtml.
 
[26]  Osher, Y., & Belmaker, R. (2009). Omega-3 Fatty Acids in Depression: A Review of Three Studies.CNS Neuroscience & Therapeutics, 15(2), 128-133.
 
[27]  Ravindran, A., Lam, R., Filteau, M., Lespérance, F., Kennedy, S., Parikh, S., & Patten, S. (2009). Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults. Journal of Affective Disorders, 117, S54-S64.
 
[28]  Rizzo, A., Corsetto, P., Montorfano, G., Opizzi, A., Faliva, M., & Giacosa, A. et al. (2012). Comparison between the AA/EPA ratio in depressed and non depressed elderly females: omega-3 fatty acid supplementation correlates with improved symptoms but does not change immunological parameters. Nutrition Journal, 11(1), 82.
 
[29]  Rondanelli, M., Giacosa, A., Opizzi, A., Pelucchi, C., La Vecchia, C., & Montorfano, G. et al. (2010). Long chain omega 3 polyunsaturated fatty acids supplementation in the treatment of elderly depression: Effects on depressive symptoms, on phospholipids fatty acids profile and on health-related quality of life. J Nutr Health Aging.
 
[30]  Rondanelli, M., Giacosa, A., Opizzi, A., Pelucchi, C., La Vecchia, C., & Montorfano, G. et al. (2011). Long chain omega 3 polyunsaturated fatty acids supplementation in the treatment of elderly depression: Effects on depressive symptoms, on phospholipids fatty acids profile and on health-related quality of life. J Nutr Health Aging, 15(1), 37-44.
 
[31]  Ross, B., Seguin, J., Sieswerda, L., & others. (2007). Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid. Lipids Health Dis, 6(21), 21.
 
[32]  Sajatovic, M., Levin, J., Fuentes-Casiano, E., Cassidy, K., Tatsuoka, C., & Jenkins, J. (2011). Illness experience and reasons for nonadherence among individuals with bipolar disorder who are poorly adherent with medication. Comprehensive Psychiatry, 52(3), 280-287.
 
[33]  Samuels, N., Gropp, C., Singer, S., & Oberbaum, M. (2008). Acupuncture for Psychiatric Illness: A Literature Review. Behavioral Medicine, 34(2), 55-64.
 
[34]  Sarris, J. J., Moylan, S. S., Camfield, D. A., Pase, M. P., Mischoulon, D. D., Berk, M. M., & ... Schweitzer, I. I. (2012). Complementary Medicine, Exercise,Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence. Evidence-Based Complementary & Alternative Medicine (Ecam), 1-20.
 
[35]  Sinclair, A. J., Begg, D., Mathai, M., & Weisinger, R. S. (2007). Omega 3 fatty acids and the brain: review of studies in depression. Asia Pacific journal of clinical nutrition, 16(S1), 391-397.‏
 
[36]  Smith, G., & Wu, S. (2012). Nurses’ beliefs, experiences and practice regarding complementary and alternative medicine in Taiwan. Journal of Clinical Nursing, 21(17-18), 2659-2667.
 
[37]  Stahl, L., Begg, D., Weisinger, R., & Sinclair, A. (2008). The role of omega-3 fatty acids in mood disorders. Current Opinion in Investigational Drugs, 9(1), 57-64.
 
[38]  Vaidyanathan, V., Rao, K., & Sastry, P. (1994). Regulation of diacylglycerol kinase in rat brain membranes by docosahexaenoic acid. Neuroscience Letters, 179(1-2), 171-174.
 
[39]  Wahlström, M., Sihvo, S., Haukkala, A., Kiviruusu, O., Pirkola, S., & Isometsä, E. (2008). Use of mental health services and complementary and alternative medicine in persons with common mental disorders. Acta Psychiatrica Scandinavica, 118(1), 73-80.
 
[40]  World Health Organization [WHO]. (2012). DEPRESSION: A Global Public Health Concern. World Health Organization. Retrieved from http://www.who.int/mental_health/management/depression/who_paper_depression_wfmh_2012.pdf.
 
[41]  World Health Organization [WHO]. (2013). WHO | Depression. Who.int. Retrieved 18 October 2014, from http://www.who.int/mental_health/management/depression/en/4.