Nevirapine Induced Toxic Epidermal Necrolysis Managed Successfully with Etanercept (A Case Report)

Dr Navtej Singh¹, Dr Rakesh Tilak Raj^2, and Dr Ruby Venugopal³

¹Unit head Department of Dermatology, Command Hospital (Western Command), Chandimandir, Punchkula (Haryana), India

²Department of Dermatology, Venereology and leprosy, Government Medical college Patiala, Patiala (Punjab), India

³Graded specialist (Dermatology & Venereology, Command Hospital (Western Command), Chandimandir, Punchkula (Haryana), India

Cite this paper:
Dr Navtej Singh, Dr Rakesh Tilak Raj and Dr Ruby Venugopal. Nevirapine Induced Toxic Epidermal Necrolysis Managed Successfully with Etanercept (A Case Report). American Journal of Medical Sciences and Medicine. 2015; 3(4):52-55. doi: 10.12691/ajmsm-3-4-3

Abstract

Toxic epidermal necrolysis (TEN) is a rare, idiosyncratic, unpredictable drug reaction. It is potentially a life threatening dermatological disorder. At present there is no definite consensus regarding the management of TEN. Treatment of TEN with etanercept has shown promising results in the recent literature where conventional systemic therapies are either contraindicated or have failed. We report a case of nevirapine induced TEN treated successfully by administering single dose of 50 mg etanercept given subcutaneously that resulted in complete re-epithelialization and without any complications.

Keywords:
adverse drug reactions reverse transcriptase inhibitor SCORTEN Etanercept Naranjo's ADR probability scale

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