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Paul, C., Wolkenstein, P., Adle, H. et al. Apoptosis as a mechanism of keratinocytes death in toxic epidermal necrolysis. Br J Dermatol., 134. 710-714. 1996.

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Article

Nevirapine Induced Toxic Epidermal Necrolysis Managed Successfully with Etanercept (A Case Report)

1Unit head Department of Dermatology, Command Hospital (Western Command), Chandimandir, Punchkula (Haryana), India

2Department of Dermatology, Venereology and leprosy, Government Medical college Patiala, Patiala (Punjab), India

3Graded specialist (Dermatology & Venereology, Command Hospital (Western Command), Chandimandir, Punchkula (Haryana), India


American Journal of Medical Sciences and Medicine. 2015, Vol. 3 No. 4, 52-55
DOI: 10.12691/ajmsm-3-4-3
Copyright © 2015 Science and Education Publishing

Cite this paper:
Dr Navtej Singh, Dr Rakesh Tilak Raj, Dr Ruby Venugopal. Nevirapine Induced Toxic Epidermal Necrolysis Managed Successfully with Etanercept (A Case Report). American Journal of Medical Sciences and Medicine. 2015; 3(4):52-55. doi: 10.12691/ajmsm-3-4-3.

Correspondence to: Dr Rakesh Tilak Raj, Department of Dermatology, Venereology and leprosy, Government Medical college Patiala, Patiala (Punjab), India. Email: rakeshtraj2012@gmail.com

Abstract

Toxic epidermal necrolysis (TEN) is a rare, idiosyncratic, unpredictable drug reaction. It is potentially a life threatening dermatological disorder. At present there is no definite consensus regarding the management of TEN. Treatment of TEN with etanercept has shown promising results in the recent literature where conventional systemic therapies are either contraindicated or have failed. We report a case of nevirapine induced TEN treated successfully by administering single dose of 50 mg etanercept given subcutaneously that resulted in complete re-epithelialization and without any complications.

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