Comprehensive Analysis of Laboratory Results of a Sjögren’s Syndrome Patient Combining Autoimmune Hepatitis with Double Negatives of the Sjögren's Ayndrome Antigen A and B

Jianwei Zhou^1, , Cui Kong², Zhaocai Zhang¹, Xinke Chen¹, Shuo Shi¹ and Liang Han¹

¹Medical Laboratory, Affiliated Hospital of Jining Medical College, Shandong Province, Jining City, PR China

²Nursing Department, Affiliated Hospital of Jining Medical College, Shandong Province, Jining City PR China

Cite this paper:
Jianwei Zhou, Cui Kong, Zhaocai Zhang, Xinke Chen, Shuo Shi and Liang Han. Comprehensive Analysis of Laboratory Results of a Sjögren’s Syndrome Patient Combining Autoimmune Hepatitis with Double Negatives of the Sjögren's Ayndrome Antigen A and B. American Journal of Medical Sciences and Medicine. 2014; 2(4):67-70. doi: 10.12691/ajmsm-2-4-1

Abstract

Objective: To analyze the laboratory results of a Sjögren’s syndrome combining autoimmune hepatitis (SS-AIH) with double negative of SSA and SSB (SSA^-SSB^-). Methods: 10 ml venous blood was collected from the patients, and the blood routine, biochemical and immunological indices were respectively detected. Results: The values of WBC, neutrophiles, ESR, ALT, AST, CRP, IgA and IgG were beyond the corresponding reference ranges, respectively. The antinuclear antibody pattern was nuclear homogenous with the titer of 1:1000. The antibodies to PM-Scl, AnuA and Rib-P were all positive. In the fluorescence immune test for AIH, anti-mitochondrial antibodies (AMA) was positive. The concentration of CCP was 92.5 U/ml which also was beyond the reference range. Conclusion: There are certain changes in the laboratory results for the SS-AIH patient with SSA^-SSB^-, and if the changes are the common characters for this kind of disease need further observations in future.

Keywords:
Sjögren’s syndrome autoimmune hepatitis SSA SSB

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References:

[1]	Li Z, Chen S, “Clinic rheumatism handbook”, Bejing, People publishing house, 2008.
[2]	Liu Y, Wang YF, Wang KL, Lv FF, “Prevalence and significance of immunoglobulin G-anti-cyclic citrullinated peptide antibodies in primary Sjogren's syndrome patients”, Beijing Da Xue Xue Bao, 46(3): 478-482, 2014,
[3]	Mekinian A, Nicaise-Roland P, Chollet-Martin S, Fain O, Crestani B, “Anti-SSA Ro52/Ro60 antibody testing by immunodot could help the diagnosis of Sjogren's syndrome in the absence of anti-SSA/SSB antibodies by ELISA”, Rheumatology (Oxford), 52(12): 2223-2228, 2013.
[4]	Xu YJ, Wu HX, “The correlation between immunological abnormality and systemic involvement in primary Sjögren’s syndrome”, Immunological Journal, 29(3): 243-246, 2013.
[5]	Varga J, “Systemic sclerosis: an update”, Bull NYU Hosp Jt Dis, 66: 198-202, 2008.
[6]	Sheng ML, Hao JH, Tao JH, Zhang H, Zhang ZH, Zhang GQ, et al., “Association of expression of serum antinucleosome antibody family and SLE disease activity index”, Chin J Health Lab Tech, 32(1): 95-100, 2013.
[7]	Hu ZG, Chen GQ, Zou YH, Yuan JS, Zhou Y, “Anti-ribosomal P0 protein antibodies in Systemic Lupus Erythmatosus and their clinical diagnosi significance”, Chin J Nosocomiol, 20(22): 3630-3632, 2010.
[8]	Yu YX, Zhu CX, Chi SH, Wang HY, “The correlation of plasma AnuA level with activity and organ damage in systemic lupus erythematosus patients”, China Journal of Modern Medicine, 23(9): 50-54, 2013.
[9]	Yao Z, Long L, Li ZG, “Comparisons of clinical characteristics of primary Sjögren’s syndrome onset at different ages”, Chin Rheumatol, 10(11): 683-686, 2006.
[10]	Wu CL, Liu HN, Yang PT, Zhao LH, Xiao WG, “Relationship of CCR7 expression on peripheral blood T lymphocyte with the disease activity of Sjögren’s syndrome”, Immunological Journal, 26(11): 953-955, 961, 2010.