Clinical and Histological Features in Wegener Granulomatosis

Li Cavoli Gioacchino^1, , Passantino Rita², Bono Luisa¹, Tortorici Calogera¹, Ferrantelli Angelo¹, Giammarresi Carlo² and Rotolo Ugo

¹Nephrology and Dialysis, Civic and Di Cristina Hospital, Palermo, Italy

²Anatomic Pathology, Civic and Di Cristina Hospital, Palermo, Italy

Cite this paper:
Li Cavoli Gioacchino, Passantino Rita, Bono Luisa, Tortorici Calogera, Ferrantelli Angelo, Giammarresi Carlo and Rotolo Ugo. Clinical and Histological Features in Wegener Granulomatosis. American Journal of Medical Sciences and Medicine. 2013; 1(1):1-4. doi: 10.12691/ajmsm-1-1-1

Abstract

Wegener Granulomatosis is a systemic ANCA-associated Vasculitis, affecting small-to-medium vessels. Clinical presentation with simultaneous involvement of kidney and upper and lower respiratory tract is unusual. There are few histological reports regarding lung biopsy in WG because clinical and radiologic features are diagnostic. Sometimes radiologic findings can be unusual. We detected an instructive case of WG, analyzing clinical course, laboratory and radiological features, kidney, lung and larynx histological pictures. Besides renal biopsy, nephrology team performed larynx and lung biopsies because of unusual clinical presentation, computed tomography chest examination and relevant malignancy risk regarding following immunosuppressant therapy. WG is a point of interest for clinical multidisciplinary activity. Diagnosis of WG is a combination of clinical, laboratory and pathologic features. Collaboration between different specialities help to improve current diagnostic activity.

Keywords:
Vasculitis ANCA Renal failure

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